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This article provides an introduction to the Regression Discontinuity (RD) design, and its application to empirical research in the medical sciences. While the main focus of this article is on causal interpretation, key concepts of…

Methodology · Statistics 2025-08-07 Matias D. Cattaneo , Rocio Titiunik

Regression discontinuity (RD) designs are popular quasi-experimental studies in which treatment assignment depends on whether the value of a running variable exceeds a cutoff. RD designs are increasingly popular in educational applications…

Methodology · Statistics 2024-07-23 Daryl Swartzentruber , Eloise Kaizar

The increasing popularity of regression discontinuity methods for causal inference in observational studies has led to a proliferation of different estimating strategies, most of which involve first fitting non-parametric regression models…

Methodology · Statistics 2018-06-11 Guido Imbens , Stefan Wager

Observational studies often benefit from an abundance of observational units. This can lead to studies that -- while challenged by issues of internal validity -- have inferences derived from sample sizes substantially larger than randomized…

Methodology · Statistics 2020-08-24 Rachael C. Aikens , Dylan Greaves , Michael Baiocchi

The Regression Discontinuity (RD) design is one of the most widely used non-experimental methods for causal inference and program evaluation. Over the last two decades, statistical and econometric methods for RD analysis have expanded and…

Econometrics · Economics 2022-02-25 Matias D. Cattaneo , Rocio Titiunik

Regression discontinuity (RD) designs are a popular approach to estimating a treatment effect of cutoff-based interventions. Two current estimation approaches dominate the literature. One fits separate regressions on either side of the…

Methodology · Statistics 2025-03-10 Daryl Swartzentruber , Eloise Kaizar

We study regression discontinuity designs in which many predetermined covariates, possibly much more than the number of observations, can be used to increase the precision of treatment effect estimates. We consider a two-step estimator…

Econometrics · Economics 2022-05-06 Alexander Kreiß , Christoph Rothe

This monograph, together with its accompanying first part Cattaneo, Idrobo and Titiunik (2020), collects and expands the instructional materials we prepared for more than $50$ short courses and workshops on Regression Discontinuity (RD)…

Methodology · Statistics 2024-03-27 Matias D. Cattaneo , Nicolas Idrobo , Rocio Titiunik

This paper considers the design of observational longitudinal studies with a continuous response and a binary time-invariant exposure, where, typically, the exposure is unbalanced, the mean response in the two groups differs at baseline and…

Methodology · Statistics 2022-09-27 Xavier Basagana , Donna Spiegelman

We present a practical guide for the analysis of regression discontinuity (RD) designs in biomedical contexts. We begin by introducing key concepts, assumptions, and estimands within both the continuity-based framework and the local…

Methodology · Statistics 2023-05-17 Matias D. Cattaneo , Luke Keele , Rocio Titiunik

Regression discontinuity designs have become one of the most popular research designs in empirical economics. We argue, however, that widely used approaches to building confidence intervals in regression discontinuity designs exhibit…

Econometrics · Economics 2025-12-01 Aditya Ghosh , Guido Imbens , Stefan Wager

Reinforcement learning (RL) has the potential to significantly improve clinical decision making. However, treatment policies learned via RL from observational data are sensitive to subtle choices in study design. We highlight a simple…

Machine Learning · Computer Science 2020-12-23 Christina X. Ji , Michael Oberst , Sanjat Kanjilal , David Sontag

The regression discontinuity (RD) design is widely used for program evaluation with observational data. The primary focus of the existing literature has been the estimation of the local average treatment effect at the existing treatment…

Methodology · Statistics 2024-09-05 Yi Zhang , Eli Ben-Michael , Kosuke Imai

Doubly robust learning offers a robust framework for causal inference from observational data by integrating propensity score and outcome modeling. Despite its theoretical appeal, practical adoption remains limited due to perceived…

Machine Learning · Statistics 2024-07-09 Hlynur Davíð Hlynsson

Selecting input variables or design points for statistical models has been of great interest in adaptive design and active learning. Motivated by two scientific examples, this paper presents a strategy of selecting the design points for a…

Machine Learning · Statistics 2021-02-12 Chiwoo Park , Peihua Qiu , Jennifer Carpena-Núñez , Rahul Rao , Michael Susner , Benji Maruyama

The undergraduate curriculum in statistics and data science is undergoing changes to accommodate new methods, newly interested students, and the changing role of statistics in society. Because of this, it is more important than ever that…

Other Statistics · Statistics 2025-12-17 Lee Kennedy-Shaffer

The dramatic growth of big datasets presents a new challenge to data storage and analysis. Data reduction, or subsampling, that extracts useful information from datasets is a crucial step in big data analysis. We propose an orthogonal…

Methodology · Statistics 2021-06-01 Lin Wang , Jake Elmstedt , Weng Kee Wong , Hongquan Xu

For learning about the causal effect of a treatment, a randomized controlled trial (RCT) is considered the gold standard. However, randomizing treatment is sometimes unethical or infeasible, and instead an observational study may be…

Methodology · Statistics 2024-04-01 Dylan S. Small

The development and use of dimension reduction methods is prevalent in modern statistical literature. This paper reviews a class of dimension reduction techniques which aim to simultaneously select relevant predictors and find clusters…

Methodology · Statistics 2022-02-18 Suchit Mehrotra

Likelihood methods for measuring statistical evidence obey the likelihood principle while maintaining bounded and well-controlled frequency properties. These methods lend themselves to sequential study designs because they measure the…

Methodology · Statistics 2017-11-07 Jeffrey D Blume , Leena Choi
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