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Retrieval augmentation is critical when Language Models (LMs) exploit non-parametric knowledge related to the query through external knowledge bases before reasoning. The retrieved information is incorporated into LMs as context alongside…

Information Retrieval · Computer Science 2024-11-21 Mingzhu Wang , Yuzhe Zhang , Qihang Zhao , Junyi Yang , Hong Zhang

AI tools, particularly large-scale language model (LLM) based applications such as ChatGPT, have the potential to simplify qualitative research. Through semi-structured interviews with seventeen participants, we identified challenges and…

Human-Computer Interaction · Computer Science 2025-05-14 He Zhang , Chuhao Wu , Jingyi Xie , Yao Lyu , Jie Cai , John M. Carroll

Autonomous agents powered by large language models (LLMs) promise to accelerate scientific discovery end-to-end, but rigorously evaluating their capacity for verifiable discovery remains a central challenge. Existing benchmarks face a…

Artificial Intelligence · Computer Science 2026-02-04 Zhen Wang , Fan Bai , Zhongyan Luo , Jinyan Su , Kaiser Sun , Xinle Yu , Jieyuan Liu , Kun Zhou , Claire Cardie , Mark Dredze , Eric P. Xing , Zhiting Hu

Language models are revolutionizing the biochemistry domain, assisting scientists in drug design and chemical synthesis with high efficiency. Yet current approaches struggle between small language models prone to hallucination and limited…

Machine Learning · Computer Science 2026-02-02 Hao Li , He Cao , Shenyao Peng , Zijing Liu , Bin Feng , Yu Wang , Zhiyuan Yan , Yonghong Tian , Yu Li , Li Yuan

Collaboration is the defining mode of modern science, yet its core mechanism -- feedback -- remains hard to observe, difficult to scale, and unequally distributed. Here we test whether large language models (LLMs) can contribute to this…

Physics and Society · Physics 2026-05-26 Binglu Wang , Weixin Liang , Jiahui Xue , Yuhui Zhang , Hancheng Cao , Dashun Wang , Yian Yin

With recent Nobel Prizes recognising AI contributions to science, Large Language Models (LLMs) are transforming scientific research by enhancing productivity and reshaping the scientific method. LLMs are now involved in experimental design,…

Nuclear waste management requires rigorous regulatory compliance assessment, demanding advanced decision-support systems capable of addressing complex legal, environmental, and safety considerations. This paper presents a multi-agent…

Multiagent Systems · Computer Science 2025-05-29 Dongjune Chang , Sola Kim , Young Soo Park

Predicting chemical reactions, a fundamental challenge in chemistry, involves forecasting the resulting products from a given reaction process. Conventional techniques, notably those employing Graph Neural Networks (GNNs), are often limited…

Machine Learning · Computer Science 2023-10-23 Yaorui Shi , An Zhang , Enzhi Zhang , Zhiyuan Liu , Xiang Wang

While large language models (LLMs) with Chain-of-Thought (CoT) reasoning excel in mathematics and coding, their potential for systematic reasoning in chemistry, a domain demanding rigorous structural analysis for real-world tasks like drug…

Artificial Intelligence · Computer Science 2026-01-08 Hao Li , He Cao , Bin Feng , Yanjun Shao , Xiangru Tang , Zhiyuan Yan , Li Yuan , Yonghong Tian , Yu Li

Systematic reviews require the use of rigorously designed search strategies to ensure both comprehensive retrieval and minimization of bias. Conventional manual approaches, although methodologically systematic, are resource-intensive and…

Information Retrieval · Computer Science 2026-02-03 Fatima Nasser , Fouad Trad , Ammar Mohanna , Ghada El-Hajj Fuleihan , Ali Chehab

To fully expedite AI-powered chemical research, high-quality chemical databases are the foundation. Automatic extraction of chemical information from the literature is essential for constructing reaction databases, but it is currently…

Artificial Intelligence · Computer Science 2026-03-09 Yufan Chen , Ching Ting Leung , Bowen Yu , Jianwei Sun , Yong Huang , Linyan Li , Hao Chen , Hanyu Gao

While search is the predominant method of accessing information, formulating effective queries remains a challenging task, especially for situations where the users are not familiar with a domain, or searching for documents in other…

Artificial Intelligence · Computer Science 2023-11-21 Kaustubh D. Dhole , Ramraj Chandradevan , Eugene Agichtein

Large language models (LLMs) have increasingly been applied to automatic programming code generation. This task can be viewed as a language generation task that bridges natural language, human knowledge, and programming logic. However, it…

Chemical large language models (LLMs) predominantly rely on explicit Chain-of-Thought (CoT) in natural language to perform complex reasoning. However, chemical reasoning is inherently continuous and structural, and forcing it into discrete…

Recent breakthroughs in machine learning and artificial intelligence, fueled by scientific data, are revolutionizing the discovery of new materials. Despite the wealth of existing scientific literature, the availability of both structured…

Chemical Physics · Physics 2024-10-08 Mehrad Ansari , Jeffrey Watchorn , Carla E. Brown , Joseph S. Brown

As a cornerstone of modern information access, search engines have become indispensable in everyday life. With the rapid advancements in AI and natural language processing (NLP) technologies, particularly large language models (LLMs),…

Computation and Language · Computer Science 2025-08-07 Fengran Mo , Kelong Mao , Ziliang Zhao , Hongjin Qian , Haonan Chen , Yiruo Cheng , Xiaoxi Li , Yutao Zhu , Zhicheng Dou , Jian-Yun Nie

Given the remarkable performance of Large Language Models (LLMs), an important question arises: Can LLMs conduct human-like scientific research and discover new knowledge, and act as an AI scientist? Scientific discovery is an iterative…

Machine Learning · Computer Science 2025-02-24 Tingting Chen , Srinivas Anumasa , Beibei Lin , Vedant Shah , Anirudh Goyal , Dianbo Liu

With the growing success of Large Language models (LLMs) in information-seeking scenarios, search engines are now adopting generative approaches to provide answers along with in-line citations as attribution. While existing work focuses…

Information Retrieval · Computer Science 2024-09-13 Hanane Djeddal , Pierre Erbacher , Raouf Toukal , Laure Soulier , Karen Pinel-Sauvagnat , Sophia Katrenko , Lynda Tamine

The integration of large language models (LLMs) into materials science offers a transformative opportunity to streamline computational workflows, yet current agentic systems remain constrained by rigid, carefully crafted domain-specific…

Materials Science · Physics 2026-04-08 Fengxu Yang , Jack D. Evans

Retrosynthesis analysis is pivotal yet challenging in drug discovery and organic chemistry. Despite the proliferation of computational tools over the past decade, AI-based systems often fall short in generalizing across diverse reaction…

Machine Learning · Computer Science 2024-08-21 Yifei Yang , Runhan Shi , Zuchao Li , Shu Jiang , Bao-Liang Lu , Yang Yang , Hai Zhao