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Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

Computation and Language · Computer Science 2026-01-21 Muhammad Muneeb , David B. Ascher

Recently, Large Language Models (LLMs) have gained significant traction in medical domain, especially in developing a QA systems to Medical QA systems for enhancing access to healthcare in low-resourced settings. This paper compares five…

Computation and Language · Computer Science 2026-02-17 Shefayat E Shams Adib , Ahmed Alfey Sani , Ekramul Alam Esham , Ajwad Abrar , Tareque Mohmud Chowdhury

In practice, clinicians achieve a diagnosis by following a sequence of steps, such as laboratory exams, observations, or imaging. The pathways to reach diagnosis decisions are documented by guidelines authored by expert organizations, which…

Computation and Language · Computer Science 2024-09-25 Elisa Castagnari , Lillian Muyama , Adrien Coulet

Large Language Models (LLMs) have demonstrated promise in medical knowledge assessments, yet their practical utility in real-world clinical decision-making remains underexplored. In this study, we evaluated the performance of three…

Computation and Language · Computer Science 2025-12-30 Mengdi Chai , Ali R. Zomorrodi

Radiology reports summarize key findings and differential diagnoses derived from medical imaging examinations. The extraction of differential diagnoses is crucial for downstream tasks, including patient management and treatment planning.…

Computation and Language · Computer Science 2024-10-15 Luoyao Chen , Revant Teotia , Antonio Verdone , Aidan Cardall , Lakshay Tyagi , Yiqiu Shen , Sumit Chopra

With the rising human-like precision of Large Language Models (LLMs) in numerous tasks, their utilization in a variety of real-world applications is becoming more prevalent. Several studies have shown that LLMs excel on many standard NLP…

Computation and Language · Computer Science 2024-04-03 Rishav Hada , Varun Gumma , Mohamed Ahmed , Kalika Bali , Sunayana Sitaram

Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa

Static tools like the Patient Health Questionnaire-9 (PHQ-9) effectively screen depression but lack interactivity and adaptability. We developed HopeBot, a chatbot powered by a large language model (LLM) that administers the PHQ-9 using…

Artificial Intelligence · Computer Science 2026-01-15 Zhijun Guo , Alvina Lai , Julia Ive , Alexandru Petcu , Yutong Wang , Luyuan Qi , Johan H Thygesen , Kezhi Li

With the advancements in Large Language Models (LLMs), Vision-Language Models (VLMs) have reached a new level of sophistication, showing notable competence in executing intricate cognition and reasoning tasks. However, existing evaluation…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Yuanfeng Ji , Chongjian Ge , Weikai Kong , Enze Xie , Zhengying Liu , Zhengguo Li , Ping Luo

In this work, we designed unbiased prompts to systematically evaluate the psychological safety of large language models (LLMs). First, we tested five different LLMs by using two personality tests: Short Dark Triad (SD-3) and Big Five…

Computation and Language · Computer Science 2024-03-01 Xingxuan Li , Yutong Li , Lin Qiu , Shafiq Joty , Lidong Bing

With the advent of large language models (LLMs), in both the open source and proprietary domains, attention is turning to how to exploit such artificial intelligence (AI) systems in assisting complex scientific tasks, such as material…

Human-Computer Interaction · Computer Science 2024-01-26 Yongtao Liu , Marti Checa , Rama K. Vasudevan

Cognitive psychology delves on understanding perception, attention, memory, language, problem-solving, decision-making, and reasoning. Large language models (LLMs) are emerging as potent tools increasingly capable of performing human-level…

Computation and Language · Computer Science 2023-04-13 Sifatkaur Dhingra , Manmeet Singh , Vaisakh SB , Neetiraj Malviya , Sukhpal Singh Gill

Medical Large Vision-Language Models (Med-LVLMs) demonstrate significant potential in healthcare, but their reliance on general medical data and coarse-grained global visual understanding limits them in intelligent ophthalmic diagnosis.…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Sijing Li , Tianwei Lin , Lingshuai Lin , Wenqiao Zhang , Jiang Liu , Xiaoda Yang , Juncheng Li , Yucheng He , Xiaohui Song , Jun Xiao , Yueting Zhuang , Beng Chin Ooi

Purpose: Enhanced health literacy has been linked to better health outcomes; however, few interventions have been studied. We investigate whether large language models (LLMs) can serve as a medium to improve health literacy in children and…

Computation and Language · Computer Science 2023-11-17 Kanhai S. Amin , Linda Mayes , Pavan Khosla , Rushabh Doshi

Background: Rapid advancements in natural language processing have led to the development of large language models with the potential to revolutionize mental health care. These models have shown promise in assisting clinicians and providing…

Computation and Language · Computer Science 2024-05-16 Birger Moell

Although supervised machine learning is popular for information extraction from clinical notes, creating large annotated datasets requires extensive domain expertise and is time-consuming. Meanwhile, large language models (LLMs) have…

Computation and Language · Computer Science 2024-01-26 Madhumita Sushil , Travis Zack , Divneet Mandair , Zhiwei Zheng , Ahmed Wali , Yan-Ning Yu , Yuwei Quan , Atul J. Butte

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

In recent years, pre-trained large language models (LLMs) have achieved tremendous success in the field of Natural Language Processing (NLP). Prior studies have primarily focused on general and generic domains, with relatively less research…

Although both Google Gemini (1.5 Flash) and ChatGPT (4o and 4o-mini) give research quality evaluation scores that correlate positively with expert scores in nearly all fields, and more strongly that citations in most, it is not known…

Digital Libraries · Computer Science 2025-08-12 Mike Thelwall

Large Language Models (LLMs) have revolutionized the field of Natural Language Processing thanks to their ability to reuse knowledge acquired on massive text corpora on a wide variety of downstream tasks, with minimal (if any) tuning steps.…

Computation and Language · Computer Science 2024-07-12 Flavio Petruzzellis , Alberto Testolin , Alessandro Sperduti