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Matching patients to clinical trial options is critical for identifying novel treatments, especially in oncology. However, manual matching is labor-intensive and error-prone, leading to recruitment delays. Pipelines incorporating large…

Computation and Language · Computer Science 2025-09-25 Braxton A. Morrison , Madhumita Sushil , Jacob S. Young

Interacting with human via high-quality multi-turn dialogues is a key feature of large language models (LLMs). However, human-based evaluation of such capability involves intensive manual labor. This report provides a preliminary evaluation…

Computation and Language · Computer Science 2023-10-23 Haodong Duan , Jueqi Wei , Chonghua Wang , Hongwei Liu , Yixiao Fang , Songyang Zhang , Dahua Lin , Kai Chen

Large Language Models (LLMs) evaluation is a patchy and inconsistent landscape, and it is becoming clear that the quality of automatic evaluation metrics is not keeping up with the pace of development of generative models. We aim to improve…

Computation and Language · Computer Science 2023-10-24 Andrea Sottana , Bin Liang , Kai Zou , Zheng Yuan

Background: Clinical guidelines are central to safe evidence-based medicine in modern healthcare, providing diagnostic criteria, treatment options and monitoring advice for a wide range of illnesses. LLM-empowered chatbots have shown great…

Computation and Language · Computer Science 2025-05-07 Julia Ive , Felix Jozsa , Nick Jackson , Paulina Bondaronek , Ciaran Scott Hill , Richard Dobson

Recent claims suggest that large language models (LMs) underperform humans in comprehending minimally complex English statements (Dentella et al., 2024). Here, we revisit those findings and argue that human performance was overestimated,…

Computation and Language · Computer Science 2025-05-15 Adele E Goldberg , Supantho Rakshit , Jennifer Hu , Kyle Mahowald

Recent advances in large language models (LLMs) have shown impressive ability in biomedical question-answering, but have not been adequately investigated for more specific biomedical applications. This study investigates the performance of…

Computation and Language · Computer Science 2024-03-29 Shan Chen , Yingya Li , Sheng Lu , Hoang Van , Hugo JWL Aerts , Guergana K. Savova , Danielle S. Bitterman

In radiology, Artificial Intelligence (AI) has significantly advanced report generation, but automatic evaluation of these AI-produced reports remains challenging. Current metrics, such as Conventional Natural Language Generation (NLG) and…

Computation and Language · Computer Science 2024-02-20 Qingqing Zhu , Xiuying Chen , Qiao Jin , Benjamin Hou , Tejas Sudharshan Mathai , Pritam Mukherjee , Xin Gao , Ronald M Summers , Zhiyong Lu

This study explores the application of Large Language Models (LLMs), specifically GPT-4, in the analysis of classroom dialogue, a crucial research task for both teaching diagnosis and quality improvement. Recognizing the knowledge-intensive…

Computation and Language · Computer Science 2024-10-08 Yun Long , Haifeng Luo , Yu Zhang

Large language models (LLMs) exhibit expert-level performance in tasks across a wide range of different domains. Ethical issues raised by LLMs and the need to align future versions makes it important to know how state of the art models…

Artificial Intelligence · Computer Science 2024-05-24 Guilherme F. C. F. Almeida , José Luiz Nunes , Neele Engelmann , Alex Wiegmann , Marcelo de Araújo

Artificial Intelligence (AI) chatbots leveraging Large Language Models (LLMs) are gaining traction in healthcare for their potential to automate patient interactions and aid clinical decision-making. This study examines the reliability of…

Artificial Intelligence · Computer Science 2024-05-24 Ayesha Siddika Nipu , K M Sajjadul Islam , Praveen Madiraju

Recent advancements in large language models (LLMs) like ChatGPT and LLaMA show promise in medical applications, yet challenges remain in medical language comprehension. This study presents Me-LLaMA, a new medical LLM family based on…

Artificial intelligence (AI) has gained significant attention in healthcare consultation due to its potential to improve clinical workflow and enhance medical communication. However, owing to the complex nature of medical information, large…

Computation and Language · Computer Science 2024-03-05 Xiaolan Chen , Ziwei Zhao , Weiyi Zhang , Pusheng Xu , Le Gao , Mingpu Xu , Yue Wu , Yinwen Li , Danli Shi , Mingguang He

This study investigates the capacity of Large Language Models (LLMs) to infer the Big Five personality traits from free-form user interactions. The results demonstrate that a chatbot powered by GPT-4 can infer personality with moderate…

Human-Computer Interaction · Computer Science 2024-05-24 Heinrich Peters , Moran Cerf , Sandra C. Matz

Large language models (LLMs) have demonstrated potential applications in medicine, yet data privacy and computational burden limit their deployment in healthcare institutions. Open-source and lightweight versions of LLMs emerge as potential…

Machine Learning · Computer Science 2024-07-24 Qiuhong Wei , Ying Cui , Mengwei Ding , Yanqin Wang , Lingling Xiang , Zhengxiong Yao , Ceran Chen , Ying Long , Zhezhen Jin , Ximing Xu

Recent studies have demonstrated promising performance of ChatGPT and GPT-4 on several medical domain tasks. However, none have assessed its performance using a large-scale real-world electronic health record database, nor have evaluated…

Computation and Language · Computer Science 2023-07-18 Jingqing Zhang , Kai Sun , Akshay Jagadeesh , Mahta Ghahfarokhi , Deepa Gupta , Ashok Gupta , Vibhor Gupta , Yike Guo

This paper investigates the use of artificial intelligence chatbots for patient-specific question answering (QA) from clinical notes using several large language model (LLM) based systems: ChatGPT (versions 3.5 and 4), Google Bard, and…

Computation and Language · Computer Science 2023-06-06 Alaleh Hamidi , Kirk Roberts

Large language models (LLMs) have demonstrated powerful text generation capabilities, bringing unprecedented innovation to the healthcare field. While LLMs hold immense promise for applications in healthcare, applying them to real clinical…

Computation and Language · Computer Science 2023-10-16 Rui Yang , Edison Marrese-Taylor , Yuhe Ke , Lechao Cheng , Qingyu Chen , Irene Li

Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…

The new polymath Large Language Models (LLMs) can speed-up greatly scientific reviews, possibly using more unbiased quantitative metrics, facilitating cross-disciplinary connections, and identifying emerging trends and research gaps by…

Computation and Language · Computer Science 2023-12-08 Chenxi Wu , Alan John Varghese , Vivek Oommen , George Em Karniadakis

The ChatGPT, a lite and conversational variant of Generative Pretrained Transformer 4 (GPT-4) developed by OpenAI, is one of the milestone Large Language Models (LLMs) with billions of parameters. LLMs have stirred up much interest among…

Computation and Language · Computer Science 2023-08-01 Hanyao Huang , Ou Zheng , Dongdong Wang , Jiayi Yin , Zijin Wang , Shengxuan Ding , Heng Yin , Chuan Xu , Renjie Yang , Qian Zheng , Bing Shi