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Zebrafish pretectal neurons exhibit specificities for large-field optic flow patterns associated with rotatory or translatory body motion. We investigate the hypothesis that these specificities reflect the input statistics of natural optic…

Neurons and Cognition · Quantitative Biology 2018-10-10 Gerrit A. Ecke , Fabian A. Mikulasch , Sebastian A. Bruijns , Thede Witschel , Aristides B. Arrenberg , Hanspeter A. Mallot

Objective: This paper presents a novel heart sound segmentation algorithm based on Temporal-Framing Adaptive Network (TFAN), including state transition loss and dynamic inference for decoding the most likely state sequence. Methods: In…

Signal Processing · Electrical Eng. & Systems 2020-07-21 Xingyao Wang , Chengyu Liu , Yuwen Li , Xianghong Cheng , Jianqing Li , Gari D. Clifford

Classification is one of the core problems in Computer-Aided Diagnosis (CAD), targeting for early cancer detection using 3D medical imaging interpretation. High detection sensitivity with desirably low false positive (FP) rate is critical…

Computer Vision and Pattern Recognition · Computer Science 2014-05-20 Meizhu Liu , Le Lu , Xiaojing Ye , Shipeng Yu

Data fusion models based on Coupled Matrix and Tensor Factorizations (CMTF) have been effective tools for joint analysis of data from multiple sources. While the vast majority of CMTF models are based on the strictly multilinear…

Machine Learning · Computer Science 2025-06-17 Carla Schenker , Xiulin Wang , David Horner , Morten A. Rasmussen , Evrim Acar

Zebrafish are a common model organism used to identify new disease therapeutics. High-throughput drug screens can be performed on larval zebrafish in multi-well plates by observing changes in behaviour following a treatment. Analysis of…

Quantitative Methods · Quantitative Biology 2022-11-09 Christopher Fusco , Angel Allen

Cardiac ultrasound (US) scanning is a commonly used techniques in cardiology to diagnose the health of the heart and its proper functioning. Therefore, it is necessary to consider ways to automate these tasks and assist medical…

The analysis of electrical impulse phenomena in cardiac muscle tissue is important for the diagnosis of heart rhythm disorders and other cardiac pathophysiology. Cardiac mapping techniques acquire local temporal measurements and combine…

Medical Physics · Physics 2022-03-21 Jan Lebert , Namita Ravi , Flavio Fenton , Jan Christoph

A model's interpretability is essential to many practical applications such as clinical decision support systems. In this paper, a novel interpretable machine learning method is presented, which can model the relationship between input…

Machine Learning · Computer Science 2022-12-06 Heming Yao , Harm Derksen , Jessica R. Golbus , Justin Zhang , Keith D. Aaronson , Jonathan Gryak , Kayvan Najarian

Subject-specific modeling is a powerful tool in cardiovascular research, providing insights beyond the reach of current clinical diagnostics. Limitations in available clinical data require the incorporation of uncertainty into models to…

Applications · Statistics 2025-07-16 Amirreza Kachabi , Sofia Altieri Correa , Naomi C. Chesler , Mitchel J. Colebank

Cardiovascular magnetic resonance (CMR) is the gold standard for assessing cardiac function, but individual cardiac cycles complicate automatic temporal comparison or sub-phase analysis. Accurate cardiac keyframe detection can eliminate…

Computer Vision and Pattern Recognition · Computer Science 2025-10-08 Sven Koehler , Sarah Kaye Mueller , Jonathan Kiekenap , Gerald Greil , Tarique Hussain , Samir Sarikouch , Florian André , Norbert Frey , Sandy Engelhardt

Larval zebrafish exhibit a variety of complex undulatory swimming patterns. This repertoire is controlled by the 300 neurons projecting from brain into spinal cord. Understanding how descending control signals shape the output of spinal…

Neurons and Cognition · Quantitative Biology 2007-05-23 Scott A. Hill , Xiao-Ping Liu , Melissa A. Borla , Jorge V. Jose , Donald M. O'Malley

There are large individual differences in physiological processes, making designing personalized health sensing algorithms challenging. Existing machine learning systems struggle to generalize well to unseen subjects or contexts and can…

Computer Vision and Pattern Recognition · Computer Science 2021-03-09 Xin Liu , Ziheng Jiang , Josh Fromm , Xuhai Xu , Shwetak Patel , Daniel McDuff

This paper introduces a novel framework for the automated tracking of cells, with a particular focus on the challenging situation of phase contrast microscopic videos. Our framework is based on a topology preserving variational segmentation…

Quantitative Methods · Quantitative Biology 2012-03-28 Michael Moeller , Martin Burger , Peter Dieterich , Albrecht Schwab

Accurate and efficient quantification of cardiac function is essential for the estimation of prognosis of cardiovascular diseases (CVDs). One of the most commonly used metrics for evaluating cardiac pumping performance is left ventricular…

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia often treated with catheter ablation procedures, but procedural outcomes are highly variable. Evaluating and improving ablation efficacy is challenging due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Yunsung Chung , Chanho Lim , Ghassan Bidaoui , Christian Massad , Nassir Marrouche , Jihun Hamm

Parameterizing mathematical models of biological systems often requires fitting to stable periodic data. In cardiac electrophysiology this typically requires converging to a stable action potential through long simulations. We explore this…

Quantitative Methods · Quantitative Biology 2025-01-16 Matt J Owen , Gary R Mirams

Accurate cardiac output (CO) estimation from photoplethysmography (PPG) is promising for unobtrusive hemodynamic monitoring, but remains difficult since CO is jointly determined by cardiac function and vascular tone. Conventional…

Medical Physics · Physics 2026-05-20 Yaowen Zhang , Bo Cui , Libera Fresiello , Peter H. Veltink , Dirk W. Donker , Ying Wang

Precise and effective processing of cardiac imaging data is critical for the identification and management of the cardiovascular diseases. We introduce IntelliCardiac, a comprehensive, web-based medical image processing platform for the…

Image and Video Processing · Electrical Eng. & Systems 2025-05-09 Ting Yu Tsai , An Yu , Meghana Spurthi Maadugundu , Ishrat Jahan Mohima , Umme Habiba Barsha , Mei-Hwa F. Chen , Balakrishnan Prabhakaran , Ming-Ching Chang

Cardiac action potential models allow examination of a variety of cardiac dynamics, including how behavior may change under specific interventions. To study a specific scenario, including patient-specific cases, model parameter sets must be…

Computational Engineering, Finance, and Science · Computer Science 2025-04-21 Darby I. Cairns , Maxfield R. Comstock , Flavio H. Fenton , Elizabeth M. Cherry

High-frequency physiological waveform modality offers deep, real-time insights into patient status. Recently, physiological foundation models based on Photoplethysmography (PPG), such as PPG-GPT, have been shown to predict critical events,…

Machine Learning · Computer Science 2025-09-29 Saurabh Kataria , Davood Fattahi , Minxiao Wang , Ran Xiao , Matthew Clark , Timothy Ruchti , Mark Mai , Xiao Hu