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The fluid dynamics video presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several numerical…

Fluid Dynamics · Physics 2010-10-18 Daniel A. Reasor , Jonathan R. Clausen , Brian M. Yun , Cyrus K. Aidun

This work outlines a diffuse interface method for the study of fracture and fragmentation in ductile metals at high strain-rates in Eulerian finite volume simulations. The work is based on an existing diffuse interface method capable of…

Computational Physics · Physics 2022-10-11 Tim Wallis , Philip T. Barton , Nikolaos Nikiforakis

The use of nanoparticles for targeted drug delivery, especially in diseased arteries, is a novel procedure. We are incorporating nanoparticles into blood vessels using a catheter, which could potentially deliver drugs precisely to affected…

Fluid Dynamics · Physics 2023-08-31 Surabhi Rathore , Dasari Srikanth

We introduce a multiphysics and geometric multiscale computational model, suitable to describe the hemodynamics of the whole human heart, driven by a four-chamber electromechanical model. We first present a study on the calibration of the…

Numerical Analysis · Mathematics 2024-03-06 Alberto Zingaro , Michele Bucelli , Roberto Piersanti , Francesco Regazzoni , Luca Dede' , Alfio Quarteroni

Cardiovascular diseases are a leading cause of death in the world, driving the development of patient-specific and benchmark models for blood flow analysis. This chapter provides a theoretical overview of the main categories of Reduced…

Numerical Analysis · Mathematics 2025-10-21 Pierfrancesco Siena , Pasquale Claudio Africa , Michele Girfoglio , Gianluigi Rozza

In this paper, we construct a novel Eulerian-Lagrangian finite volume (ELFV) method for nonlinear scalar hyperbolic equations in one space dimension. It is well known that the exact solutions to such problems may contain shocks though the…

Numerical Analysis · Mathematics 2023-02-16 Yang Yang , Jiajie Chen , Jing-Mei Qiu

We present a Lagrangian analysis of turbulent blood flow in the human left heart using high-fidelity simulations based on a patient-specific anatomical model. Leveraging a fully coupled fluid-structure-electrophysiology interaction (FSEI)…

Fluid Dynamics · Physics 2025-06-13 Fabio Guglietta , Martino Andrea Scarpolini , Francesco Viola , Luca Biferale

We develop a unified framework for the design and analysis of high-order nonconforming virtual element methods for nonlinear fourth-order reaction--diffusion problems in two dimensions, with emphasis on clamped, Navier, and…

Numerical Analysis · Mathematics 2026-02-17 Dibyendu Adak , David Mora , Alberth Silgado

We derive a variational multiscale (VMS) finite element formulation for a viscoelastic, tensor-based blood damage model. The tensor equation is numerically stabilized by a logarithmic shape tensor description that prevents unphysical,…

Numerical Analysis · Mathematics 2019-11-18 Stefan Haßler , Lutz Pauli , Marek Behr

Eulerian-Lagrangian models of particle-laden (multiphase) flows describe fluid flow and particle dynamics in the Eulerian and Lagrangian frameworks respectively. Regardless of whether the flow is turbulent or laminar, the particle dynamics…

The thermodynamical model of visco-elastic deformable solids at finite strains is formulated in a fully Eulerian way in rates. Also effects of thermal expansion or buoyancy due to evolving mass density in a gravity field are covered. The…

Analysis of PDEs · Mathematics 2023-09-14 Tomáš Roubíček

We present a computational framework for the simulation of blood flow with fully resolved red blood cells (RBCs) using a modular approach that consists of a lattice Boltzmann solver for the blood plasma, a novel finite element based solver…

Computational Physics · Physics 2019-08-28 Christos Kotsalos , Jonas Latt , Bastien Chopard

We present an adaptive reduced-order model for the efficient time-resolved simulation of fluid-structure interaction problems with complex and non-linear deformations. The model is based on repeated linearizations of the structural balance…

Fluid Dynamics · Physics 2020-04-13 Ali Thari , Vito Pasquariello , Niels Aage , Stefan Hickel

Accurate simulation of deformation processes at the atomic scale is critical for predicting the mechanical response of materials and particularly the calculation of directional flow stresses. This work presents a method for applying…

Materials Science · Physics 2025-04-21 Eliott T. Dubois , Paul Lafourcade , Jean-Bernard Maillet

High Reynolds Homogeneous Isotropic Turbulence is fully described within the Navier-Stokes (NS) equations, which are notoriously difficult to solve numerically. Engineers, interested primarily in describing turbulence at a reduced range of…

The immersed boundary (IB) method is a non-body conforming approach to fluid-structure interaction (FSI) that uses an Eulerian description of the momentum, viscosity, and incompressibility of a coupled fluid-structure system and a…

Numerical Analysis · Mathematics 2022-02-18 Jae H. Lee , Boyce E. Griffith

Modelling interfacial dynamics with soluble surfactants in a multiphase system is a challenging task. Here, we consider the numerical approximation of a phase-field surfactant model with fluid flow. The nonlinearly coupled model consists of…

Computational Physics · Physics 2020-03-02 Guangpu Zhu , Jisheng Kou , Shuyu Sun , Jun Yao , Aifen Li

Accurate and efficient modeling of cardiac blood flow is crucial for advancing data-driven tools in cardiovascular research and clinical applications. Recently, the accuracy and availability of computational fluid dynamics (CFD)…

Fluid Dynamics · Physics 2025-07-30 Eneko Lazpita , Jesus Garicano-Mena , Soledad Le Clainche

The circulatory system, comprising the heart and blood vessels, is vital for nutrient transport, waste removal, and homeostasis. Traditional computational models often treat cardiac electromechanics and blood flow dynamics separately,…

This paper introduces two variational formulations for a model of robust optimal transport, that is, the problem of designing optimal transport networks that are resilient to potential damages, balancing construction costs against the…

Analysis of PDEs · Mathematics 2025-11-10 Luigi De Masi , Andrea Marchese , Annalisa Massaccesi