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Interest in Large Language Models (LLMs) has increased drastically since the emergence of ChatGPT and the outstanding positive societal response to the ease with which it performs tasks in Natural Language Processing (NLP). The triumph of…

Computation and Language · Computer Science 2023-04-06 Oluwatosin Ogundare , Gustavo Quiros Araya

While large language models (LLMs) like ChatGPT have shown impressive capabilities in Natural Language Processing (NLP) tasks, a systematic investigation of their potential in this field remains largely unexplored. This study aims to…

Computation and Language · Computer Science 2025-08-26 Libo Qin , Qiguang Chen , Xiachong Feng , Yang Wu , Yongheng Zhang , Yinghui Li , Min Li , Wanxiang Che , Philip S. Yu

User simulation has long played a vital role in computer science due to its potential to support a wide range of applications. Language, as the primary medium of human communication, forms the foundation of social interaction and behavior.…

Large language models (LLMs) are increasingly applied in scientific research, offering new capabilities for knowledge discovery and reasoning. In single-cell biology, however, evaluation practices for both general and specialized LLMs…

Artificial Intelligence · Computer Science 2026-02-27 Jiahao Zhao , Feng Jiang , Shaowei Qin , Zhonghui Zhang , Junhao Liu , Guibing Guo , Hamid Alinejad-Rokny , Min Yang

Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing a significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional…

Large language models (LLMs) are powerful artificial intelligence (AI) tools transforming how research is conducted. However, their use in research has been met with skepticism, due to concerns about hallucinations, biases and potential…

Artificial Intelligence · Computer Science 2025-07-08 Ruian Ke , Ruy M. Ribeiro

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular…

Computation and Language · Computer Science 2025-01-16 Yin Fang , Xinle Deng , Kangwei Liu , Ningyu Zhang , Jingyang Qian , Penghui Yang , Xiaohui Fan , Huajun Chen

This research investigates the application of Large Language Models (LLMs) to augment conversational agents in process mining, aiming to tackle its inherent complexity and diverse skill requirements. While LLM advancements present novel…

Artificial Intelligence · Computer Science 2023-07-20 Urszula Jessen , Michal Sroka , Dirk Fahland

There is an increasing interest in developing LLMs for medical diagnosis to improve diagnosis efficiency. Despite their alluring technological potential, there is no unified and comprehensive evaluation criterion, leading to the inability…

Computation and Language · Computer Science 2023-08-16 Xiaoming Shi , Jie Xu , Jinru Ding , Jiali Pang , Sichen Liu , Shuqing Luo , Xingwei Peng , Lu Lu , Haihong Yang , Mingtao Hu , Tong Ruan , Shaoting Zhang

Existing works focus on fixed-size layout pattern generation, while the more practical free-size pattern generation receives limited attention. In this paper, we propose ChatPattern, a novel Large-Language-Model (LLM) powered framework for…

Computation and Language · Computer Science 2024-03-26 Zixiao Wang , Yunheng Shen , Xufeng Yao , Wenqian Zhao , Yang Bai , Farzan Farnia , Bei Yu

Large language models (LLMs), especially when instruction-tuned for chat, have become part of our daily lives, freeing people from the process of searching, extracting, and integrating information from multiple sources by offering a…

Computation and Language · Computer Science 2024-11-01 Yuxia Wang , Minghan Wang , Muhammad Arslan Manzoor , Fei Liu , Georgi Georgiev , Rocktim Jyoti Das , Preslav Nakov

Over the last few years, large language models (LLMs) have emerged as the most important breakthroughs in natural language processing (NLP) that fundamentally transform research and developments in the field. ChatGPT represents one of the…

Computation and Language · Computer Science 2023-04-13 Viet Dac Lai , Nghia Trung Ngo , Amir Pouran Ben Veyseh , Hieu Man , Franck Dernoncourt , Trung Bui , Thien Huu Nguyen

Goal-oriented de novo molecule design, namely generating molecules with specific property or substructure constraints, is a crucial yet challenging task in drug discovery. Existing methods, such as Bayesian optimization and reinforcement…

Computational Engineering, Finance, and Science · Computer Science 2025-02-28 Chuanliu Fan , Ziqiang Cao , Zicheng Ma , Nan Yu , Yimin Peng , Jun Zhang , Yiqin Gao , Guohong Fu

There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and…

The widespread adoption of Large Language Models (LLMs) and publicly available ChatGPT have marked a significant turning point in the integration of Artificial Intelligence (AI) into people's everyday lives. This study examines the ability…

Computation and Language · Computer Science 2025-10-28 Sandeep Kumar , Tirthankar Ghosal , Vinayak Goyal , Asif Ekbal

Large language models (LLMs), such as ChatGPT, have rapidly penetrated into people's work and daily lives over the past few years, due to their extraordinary conversational skills and intelligence. ChatGPT has become the fastest-growing…

Computation and Language · Computer Science 2024-09-04 Wenxuan Wang

Text evaluation has historically posed significant challenges, often demanding substantial labor and time cost. With the emergence of large language models (LLMs), researchers have explored LLMs' potential as alternatives for human…

Computation and Language · Computer Science 2023-08-15 Chi-Min Chan , Weize Chen , Yusheng Su , Jianxuan Yu , Wei Xue , Shanghang Zhang , Jie Fu , Zhiyuan Liu

Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

Quantitative Methods · Quantitative Biology 2024-02-22 Hengchuang Yin , Zhonghui Gu , Fanhao Wang , Yiparemu Abuduhaibaier , Yanqiao Zhu , Xinming Tu , Xian-Sheng Hua , Xiao Luo , Yizhou Sun

While modern dialogue systems heavily rely on large language models (LLMs), their implementation often goes beyond pure LLM interaction. Developers integrate multiple LLMs, external tools, and databases. Therefore, assessment of the…

Artificial Intelligence · Computer Science 2025-07-23 Roman Mayr , Michel Schimpf , Thomas Bohné

Single-cell omics technologies have transformed our understanding of cellular diversity by enabling high-resolution profiling of individual cells. However, the unprecedented scale and heterogeneity of these datasets demand robust frameworks…