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Deep generative models are attracting great attention for molecular design with desired properties. Most existing models generate molecules by sequentially adding atoms. This often renders generated molecules with less correlation with…

Machine Learning · Computer Science 2021-11-29 Seonghwan Seo , Jaechang Lim , Woo Youn Kim

Identification of cancer driver genes is fundamental for the development of targeted therapeutic interventions. The integration of mutational profiles with protein-protein interaction (PPI) networks offers a promising avenue for their…

Quantum Physics · Physics 2025-11-05 Patricia Marques , Andreas Wichert , Duarte Magano , Bruno Coutinho

Design of new drug compounds with target properties is a key area of research in generative modeling. We present a small drug molecule design pipeline based on graph-generative models and a comparison study of two state-of-the-art graph…

Machine Learning · Computer Science 2021-02-10 Logan Ward , Jenna A. Bilbrey , Sutanay Choudhury , Neeraj Kumar , Ganesh Sivaraman

Quantum machine intelligence starts showing its impact on satellite remote sensing (SRS). Also, recent literature exhibits that quantum generative intelligences encompass superior potential than their classical counterpart, motivating us to…

Image and Video Processing · Electrical Eng. & Systems 2025-04-17 Chia-Hsiang Lin , Si-Sheng Young

Hard combinatorial optimization problems, often mapped to Ising models, promise potential solutions with quantum advantage but are constrained by limited qubit counts in near-term devices. We present an innovative quantum-inspired framework…

Quantum Physics · Physics 2024-12-25 Co Tran , Quoc-Bao Tran , Hy Truong Son , Thang N Dinh

With the goal of designing novel inhibitors for SARS-CoV-1 and SARS-CoV-2, we propose the general molecule optimization framework, Molecular Neural Assay Search (MONAS), consisting of three components: a property predictor which identifies…

Machine Learning · Computer Science 2021-02-01 Timothy Atkinson , Saeed Saremi , Faustino Gomez , Jonathan Masci

Recent advances in quantum computing systems attract tremendous attention. Commercial companies, such as IBM, Amazon, and IonQ, have started to provide access to noisy intermediate-scale quantum computers. Researchers and entrepreneurs…

Quantum Physics · Physics 2022-09-26 Wenrui Mu , Ying Mao , Long Cheng , Qingle Wang , Weiwen Jiang , Pin-Yu Chen

Hybrid quantum-classical approaches offer potential solutions to quantum chemistry problems, yet they often manifest as constrained optimization problems. Here, we explore the interconnection between constrained optimization and generalized…

Quantum Physics · Physics 2025-03-27 Muqing Zheng , Bo Peng , Ang Li , Xiu Yang , Karol Kowalski

Current drug discovery is expensive and time-consuming. It remains a challenging task to create a wide variety of novel compounds with desirable pharmacological properties and cheaply available to low-income people. In this work, we develop…

Biomolecules · Quantitative Biology 2020-06-01 Kaifu Gao , Duc D Nguyen , Meihua Tu , Guo-Wei Wei

Quantum computing networks enable scalable collaboration and secure information exchange among multiple classical and quantum computing nodes while executing large-scale generative AI computation tasks and advanced quantum algorithms.…

Networking and Internet Architecture · Computer Science 2024-01-17 Minrui Xu , Dusit Niyato , Jiawen Kang , Zehui Xiong , Yuan Cao , Yulan Gao , Chao Ren , Han Yu

Simulating molecular systems on quantum processors has the potential to surpass classical methods in computational resource efficiency. The limited qubit connectivity, small processor size, and short coherence times of near-term quantum…

Quantum Physics · Physics 2025-04-08 Abhishek Sadhu , Aritra Sarkar , Akash Kundu

Quantum computing, with its superior computational capabilities compared to classical approaches, holds the potential to revolutionize numerous scientific domains, including pharmaceuticals. However, the application of quantum computing for…

A pivotal task for quantum computing is to speed up solving problems that are both classically intractable and practically valuable. Among these, combinatorial optimization problems have attracted tremendous attention due to their broad…

Among the genetic algorithms generally used for optimization problems in the recent decades, quantum-inspired variants are known for fast and high-fitness convergence and small resource requirement. Here the application to the patient…

Neural and Evolutionary Computing · Computer Science 2025-06-06 Akira SaiToh , Arezoo Modiri , Amit Sawant , Robabeh Rahimi

Quantum computing combined with machine learning (ML) is a highly promising research area, with numerous studies demonstrating that quantum machine learning (QML) is expected to solve scientific problems more effectively than classical ML.…

Quantum Physics · Physics 2025-07-18 Liang Zhang , Yin Xu , Mohan Wu , Liang Wang , Hua Xu

Generative modeling is a flavor of machine learning with applications ranging from computer vision to chemical design. It is expected to be one of the techniques most suited to take advantage of the additional resources provided by…

Quantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant…

Advances in classical machine learning and single-cell technologies have paved the way to understand interactions between disease cells and tumor microenvironments to accelerate therapeutic discovery. However, challenges in these machine…

Quantum Physics · Physics 2023-10-18 Anupama Ray , Dhiraj Madan , Srushti Patil , Maria Anna Rapsomaniki , Pushpak Pati

Quantum computing (QC) has gained popularity due to its unique capabilities that are quite different from that of classical computers in terms of speed and methods of operations. This paper proposes hybrid models and methods that…

Quantum Physics · Physics 2019-11-12 Akshay Ajagekar , Travis Humble , Fengqi You

We present a comprehensive study of the commute time kernel method via the effective resistance framework analyzing the quantum complexity of the originally classical approach. Our study reveals that while there is a trade-off between…

Quantum Physics · Physics 2026-01-06 Adam Wesołowski , Karim Essafi