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Fluorescence microscopy image (FMI) denoising faces critical challenges due to the compound mixed Poisson-Gaussian noise with strong spatial correlation and the impracticality of acquiring paired noisy/clean data in dynamic biomedical…

Image and Video Processing · Electrical Eng. & Systems 2025-09-25 Jizhihui Liu , Qixun Teng , Qing Ma , Junjun Jiang

Computed tomography (CT) serves as an effective tool for lung cancer screening, diagnosis, treatment, and prognosis, providing a rich source of features to quantify temporal and spatial tumor changes. Nonetheless, the diversity of CT…

Image and Video Processing · Electrical Eng. & Systems 2023-10-10 Md Selim , Jie Zhang , Faraneh Fathi , Michael A. Brooks , Ge Wang , Guoqiang Yu , Jin Chen

Image denoising techniques are essential to reducing noise levels and enhancing diagnosis reliability in low-dose computed tomography (CT). Machine learning based denoising methods have shown great potential in removing the complex and…

Computer Vision and Pattern Recognition · Computer Science 2017-08-29 Dufan Wu , Kyungsang Kim , Georges El Fakhri , Quanzheng Li

Recently, the diffusion model has emerged as a superior generative model that can produce high quality and realistic images. However, for medical image translation, the existing diffusion models are deficient in accurately retaining…

Image and Video Processing · Electrical Eng. & Systems 2023-10-31 Yunxiang Li , Hua-Chieh Shao , Xiao Liang , Liyuan Chen , Ruiqi Li , Steve Jiang , Jing Wang , You Zhang

Low-dose computed tomography (CT) plays a significant role in reducing the radiation risk in clinical applications. However, lowering the radiation dose will significantly degrade the image quality. With the rapid development and wide…

Image and Video Processing · Electrical Eng. & Systems 2022-12-08 Bin Huang , Liu Zhang , Shiyu Lu , Boyu Lin , Weiwen Wu , Qiegen Liu

We propose an effective denoising diffusion model for generating high-resolution images (e.g., 1024$\times$512), trained on small-size image patches (e.g., 64$\times$64). We name our algorithm Patch-DM, in which a new feature collage…

Computer Vision and Pattern Recognition · Computer Science 2023-08-03 Zheng Ding , Mengqi Zhang , Jiajun Wu , Zhuowen Tu

We introduce the Fixed Point Diffusion Model (FPDM), a novel approach to image generation that integrates the concept of fixed point solving into the framework of diffusion-based generative modeling. Our approach embeds an implicit fixed…

Computer Vision and Pattern Recognition · Computer Science 2024-01-18 Xingjian Bai , Luke Melas-Kyriazi

Positron emission tomography (PET) is a critical tool for diagnosing tumors and neurological disorders but poses radiation risks to patients, particularly to sensitive populations. While reducing injected radiation dose mitigates this risk,…

Image and Video Processing · Electrical Eng. & Systems 2026-04-01 Yucun Hou , Fenglin Zhan , Xin Cheng , Chenxi Li , Ziquan Yuan , Runze Liao , Haihao Wang , Jianlang Hua , Jing Wu , Jianyong Jiang

Diffusion models (DMs) have become the dominant paradigm of generative modeling in a variety of domains by learning stochastic processes from noise to data. Recently, diffusion denoising bridge models (DDBMs), a new formulation of…

Machine Learning · Computer Science 2024-11-01 Guande He , Kaiwen Zheng , Jianfei Chen , Fan Bao , Jun Zhu

Low-dose computed tomography (LDCT) reduces patient radiation exposure but introduces substantial noise that degrades image quality and hinders diagnostic accuracy. Existing denoising approaches often require many diffusion steps, limiting…

Medical Physics · Physics 2025-10-29 Qiang Li , Mojtaba Safari , Shansong Wang , Huiqiao Xie , Jie Ding , Tonghe Wang , Xiaofeng Yang

Low-dose computed tomography (LDCT) is an important topic in the field of radiology over the past decades. LDCT reduces ionizing radiation-induced patient health risks but it also results in a low signal-to-noise ratio (SNR) and a potential…

Image and Video Processing · Electrical Eng. & Systems 2022-10-03 Wenjun Xia , Qing Lyu , Ge Wang

Computed tomography (CT) involves a patient's exposure to ionizing radiation. To reduce the radiation dose, we can either lower the X-ray photon count or down-sample projection views. However, either of the ways often compromises image…

Image and Video Processing · Electrical Eng. & Systems 2023-10-12 Wenjun Xia , Yongyi Shi , Chuang Niu , Wenxiang Cong , Ge Wang

Objective: Cone-beam computed tomography (CBCT) provides a low-dose imaging alternative to conventional CT, but suffers from noise, scatter, and artifacts that degrade image quality. Synthetic CT (sCT) aims to translate CBCT to high-quality…

Medical Physics · Physics 2025-09-23 Alzahra Altalib , Chunhui Li , Alessandro Perelli

Cone-beam computed tomography (CBCT) is widely used in image-guided radiotherapy. Reconstructing CBCTs from limited-angle acquisitions (LA-CBCT) is highly desired for improved imaging efficiency, dose reduction, and better mechanical…

Medical Physics · Physics 2024-04-10 Jiacheng Xie , Hua-Chieh Shao , Yunxiang Li , You Zhang

We present a novel generative approach based on Denoising Diffusion Models (DDMs), which produces high-quality image samples along with their losslessly compressed bit-stream representations. This is obtained by replacing the standard…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Guy Ohayon , Hila Manor , Tomer Michaeli , Michael Elad

Denoising diffusion models have emerged as a dominant paradigm in image generation. Discretizing image data into tokens is a critical step for effectively integrating images with Transformer and other architectures. Although the Denoising…

Computer Vision and Pattern Recognition · Computer Science 2025-12-15 Fei Kong

Computed tomography (CT) is one of the modalities for effective lung cancer screening, diagnosis, treatment, and prognosis. The features extracted from CT images are now used to quantify spatial and temporal variations in tumors. However,…

Image and Video Processing · Electrical Eng. & Systems 2023-03-28 Md Selim , Jie Zhang , Michael A. Brooks , Ge Wang , Jin Chen

The paper focuses on Image Compression, explaining efficient approaches based on Frequent Pattern Mining(FPM). The proposed compression mechanism is based on clustering similar pixels in the image and thus using cluster identifiers in image…

Image and Video Processing · Electrical Eng. & Systems 2026-02-03 Avinash Kadimisetty , C. Oswald , B. Sivalselvan

Dose reduction in computed tomography (CT) is essential for decreasing radiation risk in clinical applications. Iterative reconstruction is one of the most promising ways to compensate for the increased noise due to reduction of photon…

Image and Video Processing · Electrical Eng. & Systems 2021-03-24 Zhuonan He , Yikun Zhang , Yu Guan , Shanzhou Niu , Yi Zhang , Yang Chen , Qiegen Liu

Photon-limited imaging arises when the number of photons collected by a sensor array is small relative to the number of detector elements. Photon limitations are an important concern for many applications such as spectral imaging, night…

Computer Vision and Pattern Recognition · Computer Science 2014-04-29 Joseph Salmon , Zachary Harmany , Charles-Alban Deledalle , Rebecca Willett