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The recent surge of generative AI has been fueled by the generative power of diffusion probabilistic models and the scalable capabilities of large language models. Despite their potential, it remains elusive whether diffusion language…
This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…
Domain adaptation allows generative language models to address specific flaws caused by the domain shift of their application. However, the traditional adaptation by further training on in-domain data rapidly weakens the model's ability to…
Instruction tuning is a pivotal technique for aligning large language models (LLMs) with human intentions, safety constraints, and domain-specific requirements. This survey provides a comprehensive overview of the full pipeline,…
Large language models respond well in high-resource languages like English but struggle in low-resource languages. It may arise from the lack of high-quality instruction following data in these languages. Directly translating English…
Detecting fine-grained differences in content conveyed in different languages matters for cross-lingual NLP and multilingual corpora analysis, but it is a challenging machine learning problem since annotation is expensive and hard to scale.…
Full-parameter fine-tuning of large language models is constrained by substantial GPU memory requirements. Low-rank adaptation methods mitigate this challenge by updating only a subset of parameters. However, these approaches often limit…
Finetuning provides a scalable and cost-effective means of customizing language models for specific tasks or response styles, with greater reliability than prompting or in-context learning. In contrast, the conventional wisdom is that…
Advancements in genomic research such as high-throughput sequencing techniques have driven modern genomic studies into "big data" disciplines. This data explosion is constantly challenging conventional methods used in genomics. In parallel…
The goal of this paper is to use multi-task learning to efficiently scale slot filling models for natural language understanding to handle multiple target tasks or domains. The key to scalability is reducing the amount of training data…
Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…
Contextualized word embeddings such as ELMo and BERT provide a foundation for strong performance across a wide range of natural language processing tasks by pretraining on large corpora of unlabeled text. However, the applicability of this…
Domain-specific large language models (LLMs), typically developed by fine-tuning a pre-trained general-purpose LLM on specialized datasets, represent a significant advancement in applied AI. A common strategy in LLM fine-tuning is…
Recently, various Large Language Models (LLMs) evaluation datasets have emerged, but most of them have issues with distorted rankings and difficulty in model capabilities analysis. Addressing these concerns, this paper introduces ANGO, a…
Despite advancements in English-dominant generative large language models, further development is needed for low-resource languages to enhance global accessibility. The primary methods for representing these languages are monolingual and…
Large Language Models (LLMs) are increasingly adopted as conversational assistants in genomics, where they are mainly used to reason over biological knowledge, annotations, and analysis outputs through natural language interfaces. However,…
Large language models (LLMs) hold great promise for specialized scientific domains such as materials science, yet adapting them efficiently and accurately to domain-specific knowledge remains challenging due to limited data and high…
Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from…
The rapid development in the performance of large language models (LLMs) is accompanied by the escalation of model size, leading to the increasing cost of model training and inference. Previous research has discovered that certain layers in…
Large Language Models are expressive tools that enable complex tasks of text understanding within Computational Social Science. Their versatility, while beneficial, poses a barrier for establishing standardized best practices within the…