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Addressing the challenge of multimodal data fusion in high-dimensional biomedical informatics, we propose MMCTOP, a MultiModal Clinical-Trial Outcome Prediction framework that integrates heterogeneous biomedical signals spanning (i)…

Machine Learning · Computer Science 2025-12-29 Carolina Aparício , Qi Shi , Bo Wen , Tesfaye Yadete , Qiwei Han

Multimodal clinical prediction faces three challenges: multiple foundation models (FMs) with complementary strengths per modality, pervasive missing modalities at training and test time, and sample-specific variation in modality…

Machine Learning · Computer Science 2026-05-19 Seungik Cho , Anqi Li , Wei Qiu

Multimodal fusion leverages information across modalities to learn better feature representations with the goal of improving performance in fusion-based tasks. However, multimodal datasets, especially in medical settings, are typically…

Machine Learning · Computer Science 2025-02-05 Alejandro Guerra-Manzanares , Farah E. Shamout

Recent advancements in Multimodal Large Language Models (MLLMs) underscore the significance of scalable models and data to boost performance, yet this often incurs substantial computational costs. Although the Mixture of Experts (MoE)…

Artificial Intelligence · Computer Science 2024-05-21 Yunxin Li , Shenyuan Jiang , Baotian Hu , Longyue Wang , Wanqi Zhong , Wenhan Luo , Lin Ma , Min Zhang

Multimodal clinical prediction is widely used to integrate heterogeneous data such as Electronic Health Records (EHR) and biosignals. However, existing methods tend to rely on static modality integration schemes and simple fusion…

Machine Learning · Computer Science 2026-01-16 Jongseok Kim , Seongae Kang , Jonghwan Shin , Yuhan Lee , Ohyun Jo

Real-world time series exhibit complex and evolving dynamics, making accurate forecasting extremely challenging. Recent multi-modal forecasting methods leverage textual information such as news reports to improve prediction, but most rely…

Machine Learning · Computer Science 2026-01-30 Lige Zhang , Ali Maatouk , Jialin Chen , Leandros Tassiulas , Rex Ying

Healthcare systems generate diverse multimodal data, including Electronic Health Records (EHR), clinical notes, and medical images. Effectively leveraging this data for clinical prediction is challenging, particularly as real-world samples…

Machine Learning · Computer Science 2025-09-01 Xiaoyang Wang , Christopher C. Yang

Effective clinical decision-making depends on iterative, multimodal reasoning across diverse sources of evidence. The recent emergence of multimodal reasoning models has significantly transformed the landscape of solving complex tasks.…

Computation and Language · Computer Science 2025-11-04 Zhongzhen Huang , Linjie Mu , Yakun Zhu , Xiangyu Zhao , Shaoting Zhang , Xiaofan Zhang

Multimodal deep learning (MDL) has emerged as a transformative approach in computational pathology. By integrating complementary information from multiple data sources, MDL models have demonstrated superior predictive performance across…

Quantitative Methods · Quantitative Biology 2025-11-17 Seth Alain Chang , Muhammad Mueez Amjad , Noorul Wahab , Ethar Alzaid , Nasir Rajpoot , Adam Shephard

Language modeling have shown impressive progress in generating compelling text with good accuracy and high semantic coherence. An interesting research direction is to augment these powerful models for specific applications using contextual…

Computation and Language · Computer Science 2023-04-05 Sabri Boughorbel , Fethi Jarray , Abdulaziz Al Homaid , Rashid Niaz , Khalid Alyafei

Multimodal learning has seen great success mining data features from multiple modalities with remarkable model performance improvement. Meanwhile, federated learning (FL) addresses the data sharing problem, enabling privacy-preserved…

Machine Learning · Computer Science 2023-03-29 Rongyu Zhang , Xiaowei Chi , Guiliang Liu , Wenyi Zhang , Yuan Du , Fangxin Wang

Text and time series data offer complementary views of financial markets: news articles provide narrative context about company events, while stock prices reflect how markets react to those events. However, despite their complementary…

Computational Engineering, Finance, and Science · Computer Science 2025-09-25 Ross Koval , Nicholas Andrews , Xifeng Yan

Due to the inherent difficulty in modeling phonetic similarities across different languages, code-switching speech recognition presents a formidable challenge. This study proposes a Collaborative-MoE, a Mixture of Experts (MoE) model that…

Computation and Language · Computer Science 2024-09-06 Hukai Huang , Jiayan Lin , Kaidi Wang , Yishuang Li , Wenhao Guan , Lin Li , Qingyang Hong

Clinical trials are the gold standard for assessing the effectiveness and safety of drugs for treating diseases. Given the vast design space of drug molecules, elevated financial cost, and multi-year timeline of these trials, research on…

Machine Learning · Computer Science 2025-01-14 Yiqing Zhang , Xiaozhong Liu , Fabricio Murai

Recent advances in clinical AI have enabled remarkable progress across many clinical domains. However, existing benchmarks and models are primarily limited to a small set of modalities and tasks, which hinders the development of large-scale…

Machine Learning · Computer Science 2025-03-21 Wei Dai , Peilin Chen , Malinda Lu , Daniel Li , Haowen Wei , Hejie Cui , Paul Pu Liang

Link prediction aims to identify potential missing triples in knowledge graphs. To get better results, some recent studies have introduced multimodal information to link prediction. However, these methods utilize multimodal information…

Artificial Intelligence · Computer Science 2023-03-21 Xinhang Li , Xiangyu Zhao , Jiaxing Xu , Yong Zhang , Chunxiao Xing

Results from Randomized Controlled Trials (RCTs) establish the comparative effectiveness of interventions, and are in turn critical inputs for evidence-based care. However, results from RCTs are presented in (often unstructured) natural…

Computation and Language · Computer Science 2023-07-19 Somin Wadhwa , Jay DeYoung , Benjamin Nye , Silvio Amir , Byron C. Wallace

Mixture-of-Experts (MoE) models scale large language models efficiently by sparsely activating experts, but once an expert is selected, it is executed fully. Hence, the trade-off between accuracy and computation in an MoE model typically…

Machine Learning · Computer Science 2026-02-09 Nurbek Tastan , Stefanos Laskaridis , Karthik Nandakumar , Samuel Horvath

Multimodal time series forecasting has garnered significant attention for its potential to provide more accurate predictions than traditional single-modality models by leveraging rich information inherent in other modalities. However, due…

Machine Learning · Computer Science 2026-02-26 Jiafeng Lin , Yuxuan Wang , Huakun Luo , Zhongyi Pei , Jianmin Wang

Clinical trials provide essential guidance for practicing Evidence-Based Medicine, though often accompanying with unendurable costs and risks. To optimize the design of clinical trials, we introduce a novel Clinical Trial Result Prediction…

Computation and Language · Computer Science 2020-10-13 Qiao Jin , Chuanqi Tan , Mosha Chen , Xiaozhong Liu , Songfang Huang
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