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Earlier diagnosis of Leukemia can save thousands of lives annually. The prognosis of leukemia is challenging without the morphological information of White Blood Cells (WBC) and relies on the accessibility of expensive microscopes and the…

Image and Video Processing · Electrical Eng. & Systems 2024-05-20 Abdul Rehman , Talha Meraj , Aiman Mahmood Minhas , Ayisha Imran , Mohsen Ali , Waqas Sultani

Label-free single-cell imaging offers a scalable, non-invasive alternative to fluorescence-based cytometry, yet inferring molecular phenotypes directly from bright-field morphology remains challenging. We present a unified Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Saqib Nazir , Ardhendu Behera

Accurate cell counting is essential in various biomedical research and clinical applications, including cancer diagnosis, stem cell research, and immunology. Manual counting is labor-intensive and error-prone, motivating automation through…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Abdurahman Ali Mohammed , Catherine Fonder , Ying Wei , Wallapak Tavanapong , Donald S Sakaguchi , Qi Li , Surya K. Mallapragada

Recently, a lot of automated white blood cells (WBC) or leukocyte classification techniques have been developed. However, all of these methods only utilize a single modality microscopic image i.e. either blood smear or fluorescence based,…

Image and Video Processing · Electrical Eng. & Systems 2022-08-18 Litao Yang , Deval Mehta , Dwarikanath Mahapatra , Zongyuan Ge

In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer

Counting and classifying blood cells is an important diagnostic tool in medicine. Support Vector Machines are increasingly popular and efficient and could replace artificial neural network systems. Here a method to classify blood cells is…

Applications · Statistics 2008-12-15 Tobias Abenius

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Creating a dataset for training supervised machine learning algorithms can be a demanding task. This is especially true for medical image segmentation since one or more specialists are usually required for image annotation, and creating…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Matheus Viana da Silva , Natália de Carvalho Santos , Julie Ouellette , Baptiste Lacoste , Cesar Henrique Comin

Computer-aided methods for analyzing white blood cells (WBC) have become widely popular due to the complexity of the manual process. Recent works have shown highly accurate segmentation and detection of white blood cells from microscopic…

Image and Video Processing · Electrical Eng. & Systems 2019-10-03 Changhun Jung , Mohammed Abuhamad , Jumabek Alikhanov , Aziz Mohaisen , Kyungja Han , DaeHun Nyang

Vision science, particularly machine vision, has been revolutionized by introducing large-scale image datasets and statistical learning approaches. Yet, human neuroimaging studies of visual perception still rely on small numbers of images…

Neurons and Cognition · Quantitative Biology 2020-01-23 Nadine Chang , John A. Pyles , Abhinav Gupta , Michael J. Tarr , Elissa M. Aminoff

Single-cell proteomics (SCP) is transforming our understanding of biological complexity by shifting from bulk proteomics, where signals are averaged over thousands of cells, to the proteome analysis of individual cells. This granular…

Quantitative Methods · Quantitative Biology 2025-04-01 Amanda Momenzadeh , Jesse G. Meyer

Computational color constancy has the important task of reducing the influence of the scene illumination on the object colors. As such, it is an essential part of the image processing pipelines of most digital cameras. One of the important…

Computer Vision and Pattern Recognition · Computer Science 2020-12-29 Egor Ershov , Alex Savchik , Illya Semenkov , Nikola Banić , Alexander Belokopytov , Daria Senshina , Karlo Koscević , Marko Subašić , Sven Lončarić

We present a new annotated microscopic cellular image dataset to improve the effectiveness of machine learning methods for cellular image analysis. Cell counting is an important step in cell analysis. Typically, domain experts manually…

Image and Video Processing · Electrical Eng. & Systems 2024-11-20 Abdurahman Ali Mohammed , Catherine Fonder , Donald S. Sakaguchi , Wallapak Tavanapong , Surya K. Mallapragada , Azeez Idris

Human immune system contains white blood cells (WBC) that are good indicator of many diseases like bacterial infections, AIDS, cancer, spleen, etc. White blood cells have been sub classified into four types: monocytes, lymphocytes,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-15 Rabia Asghar , Arslan Shaukat , Usman Akram , Rimsha Tariq

In computational imaging, hardware for signal sampling and software for object reconstruction are designed in tandem for improved capability. Examples of such systems include computed tomography (CT), magnetic resonance imaging (MRI), and…

Image and Video Processing · Electrical Eng. & Systems 2022-11-01 Andrew Olsen , Yolanda Hu , Vidya Ganapati

Image-based tracking of medical instruments is an integral part of surgical data science applications. Previous research has addressed the tasks of detecting, segmenting and tracking medical instruments based on laparoscopic video data.…

Computer-assisted surgery has been developed to enhance surgery correctness and safety. However, researchers and engineers suffer from limited annotated data to develop and train better algorithms. Consequently, the development of…

Computer Vision and Pattern Recognition · Computer Science 2020-12-24 W. -Y. Hong , C. -L. Kao , Y. -H. Kuo , J. -R. Wang , W. -L. Chang , C. -S. Shih

Quantifying the number of molecules from fluorescence microscopy measurements is an important topic in cell biology and medical research. In this work, we present a consecutive algorithm for super-resolution (STED) scanning microscopy that…

Applications · Statistics 2023-10-03 Katharina Proksch , Frank Werner , Jan Keller-Findeisen , Haisen Ta , Axel Munk

Building accurate and robust artificial intelligence systems for medical image assessment requires not only the research and design of advanced deep learning models but also the creation of large and curated sets of annotated training…

Computer Vision and Pattern Recognition · Computer Science 2022-01-05 Florin C. Ghesu , Bogdan Georgescu , Awais Mansoor , Youngjin Yoo , Dominik Neumann , Pragneshkumar Patel , R. S. Vishwanath , James M. Balter , Yue Cao , Sasa Grbic , Dorin Comaniciu

Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Winnie Pang , Xueyi Ke , Satoshi Tsutsui , Bihan Wen
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