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Developing an efficient sampler capable of generating independent and identically distributed (IID) samples from a Boltzmann distribution is a crucial challenge in scientific research, e.g. molecular dynamics. In this work, we intend to…

Machine Learning · Computer Science 2026-03-10 RuiKang OuYang , Bo Qiang , José Miguel Hernández-Lobato

In this work, we consider the problem of training a generator from evaluations of energy functions or unnormalized densities. This is a fundamental problem in probabilistic inference, which is crucial for scientific applications such as…

Machine Learning · Computer Science 2024-08-30 Dongyeop Woo , Sungsoo Ahn

Energy-Based Models (EBMs) assign unnormalized log-probability to data samples. This functionality has a variety of applications, such as sample synthesis, data denoising, sample restoration, outlier detection, Bayesian reasoning, and many…

Machine Learning · Statistics 2019-12-23 Zengyi Li , Yubei Chen , Friedrich T. Sommer

Aligning diffusion models with user preferences has been a key challenge. Existing methods for aligning diffusion models either require retraining or are limited to differentiable reward functions. To address these limitations, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2025-02-28 Po-Hung Yeh , Kuang-Huei Lee , Jun-Cheng Chen

Density estimation is a fundamental problem in statistical learning. This problem is especially challenging for complex high-dimensional data due to the curse of dimensionality. A promising solution to this problem is given here in an…

Machine Learning · Statistics 2018-05-23 Saeed Saremi , Arash Mehrjou , Bernhard Schölkopf , Aapo Hyvärinen

We derive a minimalist but powerful deterministic denoising-diffusion model. While denoising diffusion has shown great success in many domains, its underlying theory remains largely inaccessible to non-expert users. Indeed, an understanding…

Graphics · Computer Science 2023-05-08 Eric Heitz , Laurent Belcour , Thomas Chambon

Energy-Based Models (EBMs) offer a versatile framework for modeling complex data distributions. However, training and sampling from EBMs continue to pose significant challenges. The widely-used Denoising Score Matching (DSM) method for…

Machine Learning · Statistics 2024-03-20 Mingtian Zhang , Alex Hawkins-Hooker , Brooks Paige , David Barber

Denoising diffusion probabilistic models (DDPMs) have emerged as competitive generative models yet brought challenges to efficient sampling. In this paper, we propose novel bilateral denoising diffusion models (BDDMs), which take…

Machine Learning · Computer Science 2021-09-15 Max W. Y. Lam , Jun Wang , Rongjie Huang , Dan Su , Dong Yu

Density-equalizing map (DEM) serves as a powerful technique for creating shape deformations with the area changes reflecting an underlying density function. In recent decades, DEM has found widespread applications in fields such as data…

Graphics · Computer Science 2025-11-18 Yanwen Huang , Lok Ming Lui , Gary P. T. Choi

Learning an energy-based model from data samples is a central problem in machine learning. Many recent and popular methods, such as denoising score matching for training energy-based diffusion models, use stochastic interpolants to corrupt…

Machine Learning · Computer Science 2026-05-27 Hanlin Yu , RuiKang OuYang , Partha Kaushik , Arto Klami , Michael U. Gutmann , Omar Chehab

Diffusion probabilistic models (DPMs) and their extensions have emerged as competitive generative models yet confront challenges of efficient sampling. We propose a new bilateral denoising diffusion model (BDDM) that parameterizes both the…

Audio and Speech Processing · Electrical Eng. & Systems 2022-03-28 Max W. Y. Lam , Jun Wang , Dan Su , Dong Yu

Computing equilibrium states in condensed-matter many-body systems, such as solvated proteins, is a long-standing challenge. Lacking methods for generating statistically independent equilibrium samples in "one shot", vast computational…

Machine Learning · Statistics 2019-07-15 Frank Noé , Simon Olsson , Jonas Köhler , Hao Wu

Diffusion models have shown promising potential for advancing Boltzmann Generators. However, two critical challenges persist: (1) inherent errors in samples due to model imperfections, and (2) the requirement of hundreds of functional…

Machine Learning · Computer Science 2024-09-12 Fengzhe Zhang , Jiajun He , Laurence I. Midgley , Javier Antorán , José Miguel Hernández-Lobato

Sampling from unnormalized densities is analogous to the generative modeling problem, but the target distribution is defined by a known energy function instead of data samples. Because evaluating the energy function is often costly, a…

Machine Learning · Computer Science 2026-05-06 Aaron Havens , Brian Karrer , Neta Shaul

Exploring the free-energy landscape along reaction coordinates or system parameters $\lambda$ is central to many studies of high-dimensional model systems in physics, e.g. large molecules or spin glasses. In simulations this usually…

Statistical Mechanics · Physics 2018-09-05 Viveca Lindahl , Jack Lidmar , Berk Hess

In this paper we first analyzed the inductive bias underlying the data scattered across complex free energy landscapes (FEL), and exploited it to train deep neural networks which yield reduced and clustered representation for the FEL. Our…

Statistical Mechanics · Physics 2021-03-19 Jun Zhang , Yao-Kun Lei , Xing Che , Zhen Zhang , Yi Isaac Yang , Yi Qin Gao

Modern digital cameras rely on the sequential execution of separate image processing steps to produce realistic images. The first two steps are usually related to denoising and demosaicking where the former aims to reduce noise from the…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Filippos Kokkinos , Stamatios Lefkimmiatis

Iterative generative models, such as noise conditional score networks and denoising diffusion probabilistic models, produce high quality samples by gradually denoising an initial noise vector. However, their denoising process has many…

Machine Learning · Computer Science 2021-01-08 Eric Luhman , Troy Luhman

Learning to sample from complex unnormalized distributions is a fundamental challenge in computational physics and machine learning. While score-based and variational methods have achieved success in continuous domains, extending them to…

Machine Learning · Statistics 2026-03-11 Lei Li , Zhen Wang , Lishuo Zhang

We introduce Adjoint Sampling, a highly scalable and efficient algorithm for learning diffusion processes that sample from unnormalized densities, or energy functions. It is the first on-policy approach that allows significantly more…

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