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Given two metastable states A and B of a biomolecular system, the problem is to calculate the likely paths of the transition from A to B. Such a calculation is more informative and more manageable if done for a reduced set of collective…

Computational Physics · Physics 2010-11-13 Ruijun Zhao , Juanfang Shen , Robert D. Skeel

The committor function is a central object for quantifying the transitions between metastable states of dynamical systems. Recently, a number of computational methods based on deep neural networks have been developed for computing the…

Computational Physics · Physics 2024-04-10 Bo Lin , Weiqing Ren

Many complex real world phenomena exhibit abrupt, intermittent or jumping behaviors, which are more suitable to be described by stochastic differential equations under non-Gaussian L\'evy noise. Among these complex phenomena, the most…

Numerical Analysis · Mathematics 2023-09-15 Wei Wei , Ting Gao , Jinqiao Duan , Xiaoli Chen

Semiclassical transition probabilities characterize transfer of energy between "hard" and "soft" modes in various physical systems. We establish the boundary problem for singular euclidean solutions used to calculate such probabilities.…

High Energy Physics - Phenomenology · Physics 2009-10-28 S. Yu. Khlebnikov

We study a version of the Ornstein-Uhlenbeck bridge driven by a spectrally-positive subordinator. Our formulation is based on a Linear-Quadratic control subject to a singular terminal condition. The Ornstein-Uhlenbeck bridge, we develop, is…

Optimization and Control · Mathematics 2023-05-04 Hidekazu Yoshioka , Kazutoshi Yamazaki

Optimal control theory is a powerful tool for improving figures of merit in quantum information tasks. Finding the solution to any optimal control problem via numerical optimization depends crucially on the choice of the optimization…

The numerical quantification of the statistics of rare events in stochastic processes is a challenging computational problem. We present a sampling method that constructs an ensemble of stochastic trajectories that are constrained to have…

Statistical Mechanics · Physics 2022-07-13 Javier Aguilar , Joseph W. Baron , Tobias Galla , Raul Toral

Rare events play a crucial role in many physics, chemistry, and biology phenomena, when they change the structure of the system, for instance in the case of multistability, or when they have a huge impact. Rare event algorithms have been…

Dynamical Systems · Mathematics 2022-08-24 Dario Lucente , Joran Rolland , Corentin Herbert , Freddy Bouchet

The Adaptive Multilevel Splitting algorithm is a very powerful and versatile iterative method to estimate the probability of rare events, based on an interacting particle systems. In an other article, in a so-called idealized setting, the…

Probability · Mathematics 2019-10-21 Charles-Edouard Bréhier , Ludovic Goudenège , Loic Tudela

In fields such as medicine and drug discovery, the ultimate goal of a classification is not to guess a class, but to choose the optimal course of action among a set of possible ones, usually not in one-one correspondence with the set of…

Machine Learning · Computer Science 2023-02-22 K. Dyrland , A. S. Lundervold , P. G. L. Porta Mana

Splitting probabilities quantify the likelihood of a given outcome out of competitive events. This key observable of random walk theory, historically introduced as the gambler's ruin problem, is well understood for memoryless (Markovian)…

Statistical Mechanics · Physics 2025-04-01 M. Dolgushev , T. V. Mendes , B. Gorin , K. Xie , N. Levernier , O. Bénichou , H. Kellay , R. Voituriez , T. Guérin

A probabilistic framework is proposed for the optimization of efficient switched control strategies for physical systems dominated by stochastic excitation. In this framework, the equation for the state trajectory is replaced with an…

Systems and Control · Computer Science 2017-01-10 Gianluca Meneghello , Paolo Luchini , Thomas Bewley

How to steer a given joint state probability density function to another over finite horizon subject to a controlled stochastic dynamics with hard state (sample path) constraints? In applications, state constraints may encode safety…

Optimization and Control · Mathematics 2020-04-07 Kenneth F. Caluya , Abhishek Halder

We investigate the splitting probability of a monitored continuous-time quantum walk with two targets and show that, in stark contrast to a classical random walk, it exhibits a nonanalytic, phase-transition-like behavior controlled by the…

Statistical Mechanics · Physics 2026-01-23 Prashant Singh , David A. Kessler , Eli Barkai

This paper works through the optimization of a real world planning problem, with a combination of a generative planning tool and an influence diagram solver. The problem is taken from an existing application in the domain of oil spill…

Artificial Intelligence · Computer Science 2013-02-18 John Mark Agosta

To model a complex system intrinsically separated by a barrier, we use two random Hamiltonians, coupled to each other either by a tunneling matrix element or by an intermediate transition state. We study that model in the universal limit of…

Quantum Physics · Physics 2024-04-22 H. A. Weidenmüller

We analyse the splitting algorithm performance in the estimation of rare event probabilities and this in a discrete multidimensional framework. For this we assume that each threshold is partitioned into disjoint subsets and the probability…

Probability · Mathematics 2016-10-10 Agnès Lagnoux , Pascal Lezaud

An exact expression of the bridge-mediated donor-acceptor effective coupling, is derived. For systems represented by a tight-binding Hamiltonian with nearest-neighbor interactions, we show that the effective coupling, is equal to the…

Soft Condensed Matter · Physics 2007-05-23 D. J. Bicout , F. Varchon , E. Kats

This article analyzes and compares two general techniques of rare event simulation for generating paths of Markov processes over fixed time horizons: exponential tilting and stochastic bridge. These two methods allow to accurately compute…

Statistical Mechanics · Physics 2025-08-27 Javier Aguilar , Riccardo Gatto

Conditions on the generator of a Markov process to control the fluctuations of its bridges are found. In particular, continuous time random walks on graphs and gradient diffusions are considered. Under these conditions, a concentration of…

Probability · Mathematics 2016-03-08 Giovanni Conforti