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Annotating medical images for disease detection is often tedious and expensive. Moreover, the available training samples for a given task are generally scarce and imbalanced. These conditions are not conducive for learning effective deep…

Accurate dose calculations in proton therapy rely on high-quality CT images. While planning CTs (pCTs) serve as a reference for dosimetric planning, Cone Beam CT (CBCT) is used throughout Adaptive Radiotherapy (ART) to generate sCTs for…

Brain tumors remain among the most lethal human diseases, where early detection and accurate classification are critical for effective diagnosis and treatment planning. Although deep learning-based computer-aided diagnostic (CADx) systems…

In radiotherapy, a trade-off exists between computational workload/speed and dose calculation accuracy. Calculation methods like pencil-beam convolution can be much faster than Monte-Carlo methods, but less accurate. The dose difference,…

Positron emission tomography (PET) is a critical tool for diagnosing tumors and neurological disorders but poses radiation risks to patients, particularly to sensitive populations. While reducing injected radiation dose mitigates this risk,…

Longitudinal MRI analysis is crucial for predicting disease outcomes, particularly in chronic conditions like hepatocellular carcinoma (HCC), where early detection can significantly influence treatment strategies and patient prognosis. Yet,…

Boron Neutron Capture Therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction 10B(n,$\alpha$)7Li, consisting in the exposition of patients to neutron…

Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional…

Radiotherapy (RT) combined with cetuximab is the standard treatment for patients with inoperable head and neck cancers. Segmentation of head and neck (H&N) tumors is a prerequisite for radiotherapy planning but a time-consuming process. In…

Tomography medical imaging is essential in the clinical workflow of modern cancer radiotherapy. Radiation oncologists identify cancerous tissues, applying delineation on treatment regions throughout all image slices. This kind of task is…

Deep models based on vision transformer (ViT) and convolutional neural network (CNN) have demonstrated remarkable performance on natural datasets. However, these models may not be similar in medical imaging, where abnormal regions cover…

Objective: There exist several X-ray computed tomography (CT) scanning strategies to reduce a radiation dose, such as (1) sparse-view CT, (2) low-dose CT, and (3) region-of-interest (ROI) CT (called interior tomography). To further reduce…

Convolutional neural network (CNN) based methods have achieved great successes in medical image segmentation, but their capability to learn global representations is still limited due to using small effective receptive fields of convolution…

Breast cancer remains a critical global health challenge, necessitating early and accurate detection for effective treatment. This paper introduces a methodology that combines automated image augmentation selection (RandAugment) with search…

Whole-body PET/CT scan is an important tool for diagnosing various malignancies (e.g., malignant melanoma, lymphoma, or lung cancer), and accurate segmentation of tumors is a key part for subsequent treatment. In recent years, CNN-based…

Contours are used in radiotherapy treatment planning to identify regions to be irradiated with high dose and regions to be spared. Therefore, any contouring uncertainty influences the whole treatment. Even though this is the biggest…

In order to optimize the radiotherapy delivery for cancer treatment, especially when dealing with complex treatments such as Total Marrow and Lymph Node Irradiation (TMLI), the accurate contouring of the Planning Target Volume (PTV) is…

Computed Tomography (CT) measures the attenuation coefficient of an object and converts the value assigned to each voxel into a CT number. In radiation therapy, CT number, which is directly proportional to the linear attenuation…

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription…

Currently, deep learning (DL) has achieved the automatic prediction of dose distribution in radiotherapy planning, enhancing its efficiency and quality. However, existing methods suffer from the over-smoothing problem for their commonly…