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Large language models (LLMs) have demonstrated their remarkable performance across various language understanding tasks. While emerging benchmarks have been proposed to evaluate LLMs in various domains such as mathematics and computer…

Artificial Intelligence · Computer Science 2024-10-28 Junnan Dong , Zijin Hong , Yuanchen Bei , Feiran Huang , Xinrun Wang , Xiao Huang

The molecular large language models have garnered widespread attention due to their promising potential on molecular applications. However, current molecular large language models face significant limitations in understanding molecules due…

Biomolecules · Quantitative Biology 2025-10-23 Zaifei Yang , Hong Chang , Ruibing Hou , Shiguang Shan , Xilin Chen

Through additional training, we explore embedding specialized scientific knowledge into the Llama 2 Large Language Model (LLM). Key findings reveal that effective knowledge integration requires reading texts from multiple perspectives,…

Computation and Language · Computer Science 2023-12-19 Kan Hatakeyama-Sato , Yasuhiko Igarashi , Shun Katakami , Yuta Nabae , Teruaki Hayakawa

Large Language Models (LLMs) have shown the potential to be valuable teaching tools, with the potential of giving every student a personalized tutor. However, one challenge with using LLMs to learn new concepts is that when learning a topic…

Human-Computer Interaction · Computer Science 2024-11-19 Steve Oney , Yue Shen , Fei Wu , Young Suh Hong , Ziang Wang , Yamini Khajekar , Jiacheng Zhang , April Yi Wang

Protein language models (pLMs) have recently gained significant attention for their ability to uncover relationships between sequence, structure, and function from evolutionary statistics, thereby accelerating therapeutic drug discovery.…

Machine Learning · Computer Science 2026-03-04 Darshan Patil , Pranshu Malviya , Mathieu Reymond , Quentin Fournier , Sarath Chandar

Pre-trained language models learn informative word representations on a large-scale text corpus through self-supervised learning, which has achieved promising performance in fields of natural language processing (NLP) after fine-tuning.…

Computation and Language · Computer Science 2023-10-31 Jian Yang , Xinyu Hu , Gang Xiao , Yulong Shen

Large language models (LLMs) have recently transformed both the academic and industrial landscapes due to their remarkable capacity to understand, analyze, and generate texts based on their vast knowledge and reasoning ability.…

Computation and Language · Computer Science 2024-09-23 Song Wang , Yaochen Zhu , Haochen Liu , Zaiyi Zheng , Chen Chen , Jundong Li

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

Recent advancements in Large Language Model (LLM) agents have demonstrated remarkable potential in automatic knowledge discovery. However, rigorously evaluating an AI's capacity for knowledge discovery remains a critical challenge. Existing…

Computation and Language · Computer Science 2026-03-05 Chaoqun Yang , Xinyu Lin , Shulin Li , Wenjie Wang , Ruihan Guo , Fuli Feng , Tat-Seng Chua

Over time, a growing wave of large language models from various series has been introduced to the community. Researchers are striving to maximize the performance of language models with constrained parameter sizes. However, from a…

Computation and Language · Computer Science 2025-11-24 Yihuai Hong , Yiran Zhao , Wei Tang , Yang Deng , Yu Rong , Wenxuan Zhang

Large language models (LLMs) have garnered significant attention for their superior performance in many knowledge-driven applications on the world wide web.These models are designed to train hundreds of millions or more parameters on large…

Computation and Language · Computer Science 2025-04-09 Bingchen Liu , Yuanyuan Fang , Naixing Xu , Shihao Hou , Xin Li , Qian Li

Large language models (LLMs) have emerged as powerful tools in natural language processing (NLP), showing a promising future of artificial generated intelligence (AGI). Despite their notable performance in the general domain, LLMs have…

Computation and Language · Computer Science 2025-01-23 Jingyuan Chen , Tao Wu , Wei Ji , Fei Wu

Large Language Models (LLMs) exhibit emerging in-context learning abilities through prompt engineering. The recent progress in large-scale generative models has further expanded their use in real-world language applications. However, the…

Computation and Language · Computer Science 2024-04-12 Linyi Yang , Shuibai Zhang , Zhuohao Yu , Guangsheng Bao , Yidong Wang , Jindong Wang , Ruochen Xu , Wei Ye , Xing Xie , Weizhu Chen , Yue Zhang

This study explores the explainability capabilities of large language models (LLMs), when employed to autonomously generate machine learning (ML) solutions. We examine two classification tasks: (i) a binary classification problem focused on…

Large language models (LLMs) have demonstrated remarkable performance on various medical benchmarks, but their capabilities across different cognitive levels remain underexplored. Inspired by Bloom's Taxonomy, we propose a…

Computation and Language · Computer Science 2025-06-11 Yuxuan Zhou , Xien Liu , Chenwei Yan , Chen Ning , Xiao Zhang , Boxun Li , Xiangling Fu , Shijin Wang , Guoping Hu , Yu Wang , Ji Wu

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Large Language Models (LLMs) have significantly transformed our daily life and established a new paradigm in natural language processing (NLP). However, the predominant pretraining of LLMs on extensive web-based texts remains insufficient…

Chemical Physics · Physics 2024-12-31 Yang Han , Ziping Wan , Lu Chen , Kai Yu , Xin Chen

Large language models (LLMs) have shown impressive capabilities across tasks such as mathematics, coding, and reasoning, yet their learning ability, which is crucial for adapting to dynamic environments and acquiring new knowledge, remains…

Computation and Language · Computer Science 2025-12-29 Zhengyu Hu , Jianxun Lian , Zheyuan Xiao , Seraphina Zhang , Tianfu Wang , Nicholas Jing Yuan , Xing Xie , Hui Xiong

The advent of Large Language Models (LLM) has revolutionized the field of natural language processing, enabling significant progress in various applications. One key area of interest is the construction of Knowledge Bases (KB) using these…

Computation and Language · Computer Science 2023-08-28 Anmol Nayak , Hari Prasad Timmapathini