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The conditional average treatment effect (CATE) is a commonly targeted statistical parameter for measuring the effect of a treatment conditional on covariates. However, the CATE will fail to capture effects of treatments beyond differences…

Methodology · Statistics 2026-04-03 Jeffrey Näf , Junhyung Park , Herbert Susmann

The Private Aggregation of Teacher Ensembles (PATE) is a machine learning framework that enables the creation of private models through the combination of multiple "teacher" models and a "student" model. The student model learns to predict…

Machine Learning · Computer Science 2023-05-22 Cuong Tran , Ferdinando Fioretto

To test scientific theories and develop individualized treatment rules, researchers often wish to learn heterogeneous treatment effects that can be consistently found across diverse populations and contexts. We consider the problem of…

Methodology · Statistics 2026-05-01 Yi Zhang , Melody Huang , Kosuke Imai

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

Across a wide array of disciplines, many researchers use machine learning (ML) algorithms to identify a subgroup of individuals who are likely to benefit from a treatment the most (``exceptional responders'') or those who are harmed by it.…

Methodology · Statistics 2025-09-03 Michael Lingzhi Li , Kosuke Imai

Conditional effect estimation has great scientific and policy importance because interventions may impact subjects differently depending on their characteristics. Most research has focused on estimating the conditional average treatment…

Methodology · Statistics 2023-04-25 Alec McClean , Zach Branson , Edward H. Kennedy

Causal machine learning holds promise for estimating individual treatment effects from complex data. For successful real-world applications of machine learning methods, it is of paramount importance to obtain reliable insights into which…

Machine Learning · Computer Science 2026-05-22 Joseph Paillard , Angel Reyero Lobo , Vitaliy Kolodyazhniy , Bertrand Thirion , Denis A. Engemann

Machine learning has become integral to medical research and is increasingly applied in clinical settings to support diagnosis and decision-making; however, its effectiveness depends on access to large, diverse datasets, which are limited…

Machine Learning · Computer Science 2026-04-21 Ke Wan , Kensuke Tanioka , Toshio Shimokawa

Observational studies enable causal inferences when randomized controlled trials (RCTs) are not feasible. However, integrating sensitive medical data across multiple institutions introduces significant privacy challenges. The data…

Distributed data analysis without revealing the individual data has recently attracted significant attention in several applications. A collaborative data analysis through sharing dimensionality reduced representations of data has been…

Machine Learning · Computer Science 2021-01-28 Akira Imakura , Anna Bogdanova , Takaya Yamazoe , Kazumasa Omote , Tetsuya Sakurai

Treatment effect estimation involves assessing the impact of different treatments on individual outcomes. Current methods estimate Conditional Average Treatment Effect (CATE) using observational datasets where covariates are collected…

Machine Learning · Computer Science 2025-02-10 Lokesh Nagalapatti , Pranava Singhal , Avishek Ghosh , Sunita Sarawagi

Randomized controlled trials (RCTs) are widely regarded as the gold standard for causal inference in biomedical research. For instance, when estimating the average treatment effect on the treated (ATT), a doubly robust estimation procedure…

Methodology · Statistics 2025-09-26 Chi-Shian Dai , Chao Ying , Yang Ning , Jiwei Zhao

We address the problem of estimating heterogeneous treatment effects in panel data, adopting the popular Difference-in-Differences (DiD) framework under the conditional parallel trends assumption. We propose a novel doubly robust…

Machine Learning · Statistics 2025-04-29 Hui Lan , Haoge Chang , Eleanor Dillon , Vasilis Syrgkanis

Understanding how treatment effects vary across patient characteristics is essential for personalized medicine, yet randomized controlled trials (RCTs) are often underpowered to detect heterogeneous treatment effects (HTEs). We propose a…

Methodology · Statistics 2025-07-22 Amir Asiaee , Chiara Di Gravio , Cole Beck , Yuting Mei , Samhita Pal , Jared D. Huling

Treatment effect estimates are often available from randomized controlled trials as a single average treatment effect for a certain patient population. Estimates of the conditional average treatment effect (CATE) are more useful for…

Methodology · Statistics 2023-09-12 Wouter A. C. van Amsterdam , Rajesh Ranganath

We propose to analyse the conditional distributional treatment effect (CoDiTE), which, in contrast to the more common conditional average treatment effect (CATE), is designed to encode a treatment's distributional aspects beyond the mean.…

Machine Learning · Statistics 2021-06-11 Junhyung Park , Uri Shalit , Bernhard Schölkopf , Krikamol Muandet

In causal inference, it is common to estimate the causal effect of a single treatment variable on an outcome. However, practitioners may also be interested in the effect of simultaneous interventions on multiple covariates of a fixed target…

Methodology · Statistics 2022-11-24 Jaime Roquero Gimenez , Dominik Rothenhäusler

Upholding data privacy especially in medical research has become tantamount to facing difficulties in accessing individual-level patient data. Estimating mixed effects binary logistic regression models involving data from multiple data…

Methodology · Statistics 2025-10-06 Marie Analiz April Limpoco , Christel Faes , Niel Hens

Causal inference across multiple data sources offers a promising avenue to enhance the generalizability and replicability of scientific findings. However, data integration methods for time-to-event outcomes, common in biomedical research,…

Methodology · Statistics 2025-05-16 Yi Liu , Alexander W. Levis , Ke Zhu , Shu Yang , Peter B. Gilbert , Larry Han

Some machine learning applications involve training data that is sensitive, such as the medical histories of patients in a clinical trial. A model may inadvertently and implicitly store some of its training data; careful analysis of the…

Machine Learning · Statistics 2017-03-06 Nicolas Papernot , Martín Abadi , Úlfar Erlingsson , Ian Goodfellow , Kunal Talwar
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