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In the fields of computation and neuroscience, much is still unknown about the underlying computations that enable key cognitive functions including learning, memory, abstraction and behavior. This paper proposes a mathematical and…

Artificial Intelligence · Computer Science 2025-01-14 Jeet Singh

The human brain is a complex dynamical system which displays a wide range of macroscopic and mesoscopic patterns of neural activity, whose mechanistic origin remains poorly understood. Whole-brain modelling allows us to explore candidate…

Neurons and Cognition · Quantitative Biology 2025-04-25 Cristiana Dimulescu , Ronja Strömsdörfer , Agnes Flöel , Klaus Obermayer

The brain can efficiently learn a wide range of tasks, motivating the search for biologically inspired learning rules for improving current artificial intelligence technology. Most biological models are composed of point neurons, and cannot…

Neurons and Cognition · Quantitative Biology 2026-04-13 Cristiano Capone , Cosimo Lupo , Paolo Muratore , Pier Stanislao Paolucci

A networked oscillator based analysis is performed for periodic bluff body flows to examine and control the transfer of kinetic energy. Spatial modes extracted from the flow field with corresponding amplitudes form a set of oscillators…

Fluid Dynamics · Physics 2018-06-27 Aditya G. Nair , Steven L. Brunton , Kunihiko Taira

Concept Bottleneck Models (CBMs) provide a basis for semantic abstractions within a neural network architecture. Such models have primarily been seen through the lens of interpretability so far, wherein they offer transparency by inferring…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Deepika SN Vemuri , Gautham Bellamkonda , Aditya Pola , Vineeth N Balasubramanian

The activity of collections of synchronizing neurons can be represented by weakly coupled nonlinear phase oscillators satisfying Kuramoto's equations. In this article, we build such neural-oscillator models, partly based on…

Neurons and Cognition · Quantitative Biology 2012-04-27 Patrick Suppes , Jose Acacio de Barros , Gary Oas

How is it that humans can solve complex planning tasks so efficiently despite limited cognitive resources? One reason is its ability to know how to use its limited computational resources to make clever choices. We postulate that people…

Machine Learning · Computer Science 2023-02-10 Ruiqi He , Falk Lieder

The brain exhibits capabilities of fast incremental learning from few noisy examples, as well as the ability to associate similar memories in autonomously-created categories and to combine contextual hints with sensory perceptions. Together…

To explain the differentiation of stem cells in terms of dynamical systems theory, models of interacting cells with intracellular protein expression dynamics are analyzed and simulated. Simulations were carried out for all possible protein…

Cell Behavior · Quantitative Biology 2015-06-15 Yusuke Goto , Kunihiko Kaneko

High-throughput experimental techniques and bioinformatics tools make it possible to obtain reconstructions of the metabolism of microbial species. Combined with mathematical frameworks such as flux balance analysis, which assumes that…

The quintessential property of neuronal systems is their intensive patterns of selective synaptic connections. The current work describes a physics-based approach to neuronal shape modeling and synthesis and its consideration for the…

Neurons and Cognition · Quantitative Biology 2009-11-10 Luciano da Fontoura Costa , Regina Celia Coelho

A central challenge in climate science and applied mathematics is developing data-driven models of multiscale systems that capture both stationary statistics and responses to external perturbations. Current neural climate emulators aim to…

Chaotic Dynamics · Physics 2026-01-27 Fabrizio Falasca

Motivation: One of the branches of Systems Biology is focused on a deep understanding of underlying regulatory networks through the analysis of the biomolecules oscillations and their interplay. Synthetic Biology exploits gene or/and…

Molecular Networks · Quantitative Biology 2020-11-30 Francesco Bardozzo , Pietro Liò , Roberto Tagliaferri

The modeling of the beating of cilia and flagella in fluids is a particularly active field of study, given the biological relevance of these organelles. Various mathematical models have been proposed to represent the nonlinear dynamics of…

Soft Condensed Matter · Physics 2024-12-10 Irene Anello , François Alouges , Antonio De Simone

Biological cells are the prototypical example of active matter. Cells sense and respond to mechanical, chemical and electrical environmental stimuli with a range of behaviors, including dynamic changes in morphology and mechanical…

Computational Engineering, Finance, and Science · Computer Science 2017-02-28 Endre Somogyi , James A. Glazier

Brain organoids recapitulate a number of brain properties, including neuronal diversity. However, do they recapitulate brain structure? Using a hydrodynamic description for cell nuclei as particles interacting initially via an effective,…

Soft Condensed Matter · Physics 2021-12-15 Ahmad Borzou , J. M. Schwarz

The biomolecules in and around a living cell -- proteins, nucleic acids, lipids, carbohydrates -- continuously sample myriad conformational states that are thermally accessible at physiological temperatures. Simultaneously, a given…

Biomolecules · Quantitative Biology 2014-07-15 Cameron Mura , Charles E. McAnany

This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

Neurons and Cognition · Quantitative Biology 2023-10-24 Giovanni Pezzulo , Leo D'Amato , Francesco Mannella , Matteo Priorelli , Toon Van de Maele , Ivilin Peev Stoianov , Karl Friston

Hopfield models, originally developed to study memory retrieval in neural networks, have become versatile tools for modeling diverse biological systems in which function emerges from collective dynamics. In this review, we provide a…

Biological Physics · Physics 2025-06-17 Maria Yampolskaya , Pankaj Mehta

The problem of model selection with a limited number of experimental trials has received considerable attention in cognitive science, where the role of experiments is to discriminate between theories expressed as computational models.…

Machine Learning · Computer Science 2023-03-07 Alexander Aushev , Aini Putkonen , Gregoire Clarte , Suyog Chandramouli , Luigi Acerbi , Samuel Kaski , Andrew Howes