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Glioblastoma, the most aggressive primary brain tumor, poses a severe clinical challenge due to its diffuse microscopic infiltration, which remains largely undetected on standard MRI. As a result, current radiotherapy planning employs a…

Glioblastoma, a highly aggressive brain tumor, poses major challenges due to its poor prognosis and high morbidity rates. Partial differential equation-based models offer promising potential to enhance therapeutic outcomes by simulating…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Zeineb Haouari , Jonas Weidner , Yeray Martin-Ruisanchez , Ivan Ezhov , Aswathi Varma , Daniel Rueckert , Bjoern Menze , Benedikt Wiestler

Our objective is the calibration of mathematical tumor growth models from a single multiparametric scan. The target problem is the analysis of preoperative Glioblastoma (GBM) scans. To this end, we present a fully automatic tumor-growth…

Medical Physics · Physics 2020-01-28 Klaudius Scheufele , Shashank Subramanian , George Biros

Glioblastoma multiforme (GBM) is a fast-growing and highly invasive brain tumour, it tends to occur in adults between the ages of 45 and 70 and it accounts for 52 percent of all primary brain tumours. Usually, GBMs are detected by magnetic…

Image and Video Processing · Electrical Eng. & Systems 2020-04-21 Matteo Rucco , Lorenzo Falsetti , Giovanna Viticchi

Glioblastoma is one of the most aggressive and deadliest types of brain cancer, with low survival rates compared to other types of cancer. Analysis of Magnetic Resonance Imaging (MRI) scans is one of the most effective methods for the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-20 Huafeng Liu , Benjamin Dowdell , Todd Engelder , Zarah Pulmano , Nicolas Osa , Arko Barman

Glioblastoma is among the most aggressive brain tumors in adults, characterized by patient-specific invasion patterns driven by the underlying brain microstructure. In this work, we present a proof-of-concept for a mathematical model of GBL…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 D. Cerrone , D. Riccobelli , S. Gazzoni , P. Vitullo , F. Ballarin , J. Falco , F. Acerbi , A. Manzoni , P. Zunino , P. Ciarletta

Gliomas are the most common primary brain tumors, evolving from the cerebral supportive cells. For clinical follow-up, the evaluation of the preoperative tumor volume is essential. Volumetric assessment of tumor volume with manual…

Predicting the infiltration of Glioblastoma (GBM) from medical MRI scans is crucial for understanding tumor growth dynamics and designing personalized radiotherapy treatment plans.Mathematical models of GBM growth can complement the data in…

Machine Learning · Computer Science 2024-08-19 Ray Zirui Zhang , Ivan Ezhov , Michal Balcerak , Andy Zhu , Benedikt Wiestler , Bjoern Menze , John S. Lowengrub

Precise prognostic modeling of glioblastoma (GBM) under varying treatment interventions is essential for optimizing clinical outcomes. While generative AI has shown promise in simulating GBM evolution, existing methods typically treat…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Chenhui Wang , Boyun Zheng , Liuxin Bao , Zhihao Peng , Peter Y. M. Woo , Hongming Shan , Yixuan Yuan

Modeling of brain tumor dynamics has the potential to advance therapeutic planning. Current modeling approaches resort to numerical solvers that simulate the tumor progression according to a given differential equation. Using…

Computational Engineering, Finance, and Science · Computer Science 2021-04-16 Ivan Ezhov , Tudor Mot , Suprosanna Shit , Jana Lipkova , Johannes C. Paetzold , Florian Kofler , Fernando Navarro , Chantal Pellegrini , Marcel Kollovieh , Marie Metz , Benedikt Wiestler , Bjoern Menze

Glioblastoma is a highly invasive brain tumor, whose cells infiltrate surrounding normal brain tissue beyond the lesion outlines visible in the current medical scans. These infiltrative cells are treated mainly by radiotherapy. Existing…

Brain tumors represent one of the most critical neurological conditions, where early and accurate diagnosis is directly correlated with patient survival rates. Manual interpretation of Magnetic Resonance Imaging (MRI) scans is…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Chinedu Emmanuel Mbonu , Tochukwu Sunday Belonwu , Okwuchukwu Ejike Chukwuogo , Kenechukwu Sylvanus Anigbogu

Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding…

Glioblastoma brain tumors are highly malignant and often require early detection and accurate segmentation for effective treatment. We are proposing two deep learning models in this paper, namely UNet and Deeplabv3, for the detection and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-02 Utkarsh Maurya , Appisetty Krishna Kalyan , Swapnil Bohidar , S. Sivakumar

Glioblastoma is a highly aggressive and malignant brain tumor type that requires early diagnosis and prompt intervention. Due to its heterogeneity in appearance, developing automated detection approaches is challenging. To address this…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Ziya Ata Yazıcı , İlkay Öksüz , Hazım Kemal Ekenel

Brain tumors are one of the most common diseases that lead to early death if not diagnosed at an early stage. Traditional diagnostic approaches are extremely time-consuming and prone to errors. In this context, computer vision-based…

Computer Vision and Pattern Recognition · Computer Science 2024-07-01 Niful Islam , Mohaiminul Islam Bhuiyan , Jarin Tasnim Raya , Nur Shazwani Kamarudin , Khan Md Hasib , M. F. Mridha , Dewan Md. Farid

Glioblastoma Multiforme is a high grade, very aggressive, brain tumor, with patients having a poor prognosis. Lower grade gliomas are less aggressive, but they can evolve into higher grade tumors over time. Patient management and treatment…

Computer Vision and Pattern Recognition · Computer Science 2018-11-01 Sergio Pereira , Raphael Meier , Victor Alves , Mauricio Reyes , Carlos A. Silva

Survival prediction models can potentially be used to guide treatment of glioblastoma patients. However, currently available MR imaging biomarkers holding prognostic information are often challenging to interpret, have difficulties…

Image and Video Processing · Electrical Eng. & Systems 2021-09-28 Sveinn Pálsson , Stefano Cerri , Hans Skovgaard Poulsen , Thomas Urup , Ian Law , Koen Van Leemput

Glioblastoma exhibits diverse, infiltrative, and patient-specific growth patterns that are only partially visible on routine MRI, making it difficult to reliably assess true tumor extent and personalize treatment planning and follow-up. We…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Valentin Biller , Niklas Bubeck , Lucas Zimmer , Ayhan Can Erdur , Sandeep Nagar , Anke Meyer-Baese , Daniel Rückert , Benedikt Wiestler , Jonas Weidner

Glioblastoma multiforme (GBM), the most aggressive primary brain tumour, exhibits low survival rates due to its rapid growth, infiltrates surrounding brain tissue, and is highly resistant to treatment. One major challenge is oedema…

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