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Recent advances in Language Models have enabled the protein modeling community with a powerful tool since protein sequences can be represented as text. Specifically, by taking advantage of Transformers, sequence-to-property prediction will…

Biomolecules · Quantitative Biology 2023-09-07 Chakradhar Guntuboina , Adrita Das , Parisa Mollaei , Seongwon Kim , Amir Barati Farimani

One of the fundamental tasks in understanding genomics is the problem of predicting Transcription Factor Binding Sites (TFBSs). With more than hundreds of Transcription Factors (TFs) as labels, genomic-sequence based TFBS prediction is a…

Machine Learning · Computer Science 2017-11-13 Jack Lanchantin , Arshdeep Sekhon , Ritambhara Singh , Yanjun Qi

Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Recently, due to their capacity and representation ability, pre-trained protein language models have achieved state-of-the-art performance in…

Biomolecules · Quantitative Biology 2024-02-06 Ziyi Zhou , Liang Zhang , Yuanxi Yu , Mingchen Li , Liang Hong , Pan Tan

The success of deep learning techniques in the computer vision domain has triggered a range of initial investigations into their utility for visual place recognition, all using generic features from networks that were trained for other…

Computer Vision and Pattern Recognition · Computer Science 2017-01-20 Zetao Chen , Adam Jacobson , Niko Sunderhauf , Ben Upcroft , Lingqiao Liu , Chunhua Shen , Ian Reid , Michael Milford

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

Protein-protein interactions (PPIs) are fundamental to numerous cellular processes, and their characterization is vital for understanding disease mechanisms and guiding drug discovery. While protein language models (PLMs) have demonstrated…

Protein-protein interactions (PPIs) govern nearly all cellular processes, yet computational methods for identifying binding partners typically produce ranked predictions without mechanistic justification. This creates a fundamental barrier…

Quantitative Methods · Quantitative Biology 2026-05-22 Kingsley Yeon , Xuefeng Liu , Promit Ghosal

Recent artificial neural networks that process natural language achieve unprecedented performance in tasks requiring sentence-level understanding. As such, they could be interesting models of the integration of linguistic information in the…

Computation and Language · Computer Science 2023-02-17 Sophie Arana , Jacques Pesnot Lerousseau , Peter Hagoort

The Gene or DNA sequence in every cell does not control genetic properties on its own; Rather, this is done through translation of DNA into protein and subsequent formation of a certain 3D structure. The biological function of a protein is…

Computational Engineering, Finance, and Science · Computer Science 2019-05-30 Leila Khalatbari , Mohammad Reza Kangavari , Saeid Hosseini , Hongzhi Yin , Ngai-Man Cheung

Sentence embeddings encode sentences in fixed dense vectors and have played an important role in various NLP tasks and systems. Methods for building sentence embeddings include unsupervised learning such as Quick-Thoughts and supervised…

Computation and Language · Computer Science 2021-06-10 Danqi Liao

This paper addresses a relatively new task: prediction of ASR performance on unseen broadcast programs. In a previous paper, we presented an ASR performance prediction system using CNNs that encode both text (ASR transcript) and speech, in…

Computation and Language · Computer Science 2018-08-29 Zied Elloumi , Laurent Besacier , Olivier Galibert , Benjamin Lecouteux

Many search systems work with large amounts of natural language data, e.g., search queries, user profiles, and documents. Building a successful search system requires a thorough understanding of textual data semantics, where deep learning…

Information Retrieval · Computer Science 2021-08-31 Weiwei Guo , Xiaowei Liu , Sida Wang , Michaeel Kazi , Zhiwei Wang , Zhoutong Fu , Jun Jia , Liang Zhang , Huiji Gao , Bo Long

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Quantitative Methods · Quantitative Biology 2025-01-08 Benoit Gaujac , Jérémie Donà , Liviu Copoiu , Timothy Atkinson , Thomas Pierrot , Thomas D. Barrett

In this paper, we applied a novel learning algorithm, namely, Deep Belief Networks (DBN) to word sense disambiguation (WSD). DBN is a probabilistic generative model composed of multiple layers of hidden units. DBN uses Restricted Boltzmann…

Computation and Language · Computer Science 2012-07-03 Peratham Wiriyathammabhum , Boonserm Kijsirikul , Hiroya Takamura , Manabu Okumura

Recent advancements in deep learning, particularly large language models (LLMs), made a significant impact on how researchers study microbiome and metagenomics data. Microbial protein and genomic sequences, like natural languages, form a…

Quantitative Methods · Quantitative Biology 2024-09-18 Binghao Yan , Yunbi Nam , Lingyao Li , Rebecca A. Deek , Hongzhe Li , Siyuan Ma

In this work we explore the application of deep neural networks to the optimization of atomic layer deposition processes based on thickness values obtained at different points of an ALD reactor. We introduce a dataset designed to train…

Machine Learning · Computer Science 2024-06-19 Angel Yanguas-Gil , Jeffrey W. Elam

T-cell receptors can recognize foreign peptides bound to major histocompatibility complex (MHC) class-I proteins, and thus trigger the adaptive immune response. Therefore, identifying peptides that can bind to MHC class-I molecules plays a…

Quantitative Methods · Quantitative Biology 2020-12-09 Ziqi Chen , Martin Renqiang Min , Xia Ning

This paper proposes a new architecture - Attentive Tensor Product Learning (ATPL) - to represent grammatical structures in deep learning models. ATPL is a new architecture to bridge this gap by exploiting Tensor Product Representations…

Computation and Language · Computer Science 2018-11-30 Qiuyuan Huang , Li Deng , Dapeng Wu , Chang Liu , Xiaodong He

With the exponential increase of the protein sequence databases over time, multiple-sequence alignment (MSA) methods, like PSI-BLAST, perform exhaustive and time-consuming database search to retrieve evolutionary information. The resulting…

Quantitative Methods · Quantitative Biology 2023-08-21 Issar Arab

Proteins are miniature machines whose function depends on their three-dimensional (3D) structure. Determining this structure computationally remains an unsolved grand challenge. A major bottleneck involves selecting the most accurate…

Quantitative Methods · Quantitative Biology 2020-11-30 Stephan Eismann , Patricia Suriana , Bowen Jing , Raphael J. L. Townshend , Ron O. Dror
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