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To obtain high-quality positron emission tomography (PET) scans while reducing radiation exposure to the human body, various approaches have been proposed to reconstruct standard-dose PET (SPET) images from low-dose PET (LPET) images. One…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Zeyu Han , Yuhan Wang , Luping Zhou , Peng Wang , Binyu Yan , Jiliu Zhou , Yan Wang , Dinggang Shen

We present a method to discover interesting brain regions in [18F] fluorodeoxyglucose positron emission tomography (PET) scans, showing also the benefits when PET scans are in combined use with non-imaging variables. The discriminative…

Neurons and Cognition · Quantitative Biology 2019-08-14 Rui Li , Robert Perneczky , Alexander Drzezga , Stefan Kramer

Positron Emission Tomography (PET) is an important clinical imaging tool but inevitably introduces radiation hazards to patients and healthcare providers. Reducing the tracer injection dose and eliminating the CT acquisition for attenuation…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Tianqi Chen , Jun Hou , Yinchi Zhou , Huidong Xie , Xiongchao Chen , Qiong Liu , Xueqi Guo , Menghua Xia , James S. Duncan , Chi Liu , Bo Zhou

Epilepsy is a highly prevalent brain condition with many serious complications arising from it. The majority of patients which present to a clinic and undergo electroencephalogram (EEG) monitoring would be unlikely to experience seizures…

Signal Processing · Electrical Eng. & Systems 2023-12-14 Matthew McDougall , Hezam Albaqami , Ghulam Mubashar Hassan , Amitava Datta

Tumor segmentation in medical imaging is crucial and relies on precise delineation. Fluorodeoxyglucose Positron-Emission Tomography (FDG-PET) is widely used in clinical practice to detect metabolically active tumors. However, FDG-PET scans…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Matthias Hadlich , Zdravko Marinov , Rainer Stiefelhagen

While Positron emission tomography (PET) imaging has been widely used in diagnosis of number of diseases, it has costly acquisition process which involves radiation exposure to patients. However, magnetic resonance imaging (MRI) is a safer…

Image and Video Processing · Electrical Eng. & Systems 2021-01-01 Hajar Emami , Qiong Liu , Ming Dong

Parametric imaging is a compartmental approach that processes nuclear imaging data to estimate the spatial distribution of the kinetic parameters governing tracer flow. The present paper proposes a novel and efficient computational method…

Numerical Analysis · Mathematics 2018-08-21 Mara Scussolini , Sara Garbarino , Gianmario Sambuceti , Giacomo Caviglia , Michele Piana

Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…

The present paper proposes a novel computational method for parametric imaging of nuclear medicine data. The mathematical procedure is general enough to work for compartmental models of diverse complexity and is effective in the…

Tissues and Organs · Quantitative Biology 2017-05-15 Mara Scussolini , Sara Garbarino , Gianmario Sambuceti , Giacomo Caviglia , Michele Piana

Minimizing the need for pixel-level annotated data to train PET lesion detection and segmentation networks is highly desired and can be transformative, given time and cost constraints associated with expert annotations. Current unsupervised…

Image and Video Processing · Electrical Eng. & Systems 2025-09-18 Shadab Ahamed , Arman Rahmim

Epilepsy is a neurological disorder classified as the second most serious neurological disease known to humanity, after stroke. Localization of the epileptogenic zone is an important step for epileptic patient treatment, which starts with…

Synthetic PET images are valuable for quantitative imaging workflow development, scalable virtual imaging trials, and deep learning model training, but conventional physics-based simulation approaches are computationally intensive, limited…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Suya Li , Kaushik Dutta , Debojyoti Pal , Jingqin Luo , Kooresh I. Shoghi

Accurate attenuation and scatter corrections are crucial in positron emission tomography (PET) imaging for accurate visual interpretation and quantitative analysis. Traditional methods relying on computed tomography (CT) or magnetic…

Medical Physics · Physics 2025-11-14 Min Jeong Cho , Hyeong Seok Shim , Sungyu Kim , Jae Sung Lee

Diffusion models have demonstrated significant potential in producing high-quality images in medical image translation to aid disease diagnosis, localization, and treatment. Nevertheless, current diffusion models have limited success in…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Yunxiang Li , Hua-Chieh Shao , Xiaoxue Qian , You Zhang

Epilepsy is a neurological condition such that it affects the brain and the nervous system. It is characterized by recurrent seizures, which are physical reactions to sudden, usually brief, excessive electrical discharges in a group of…

Signal Processing · Electrical Eng. & Systems 2018-07-30 Asmaa Hamad , Aboul Ella Hassanien , Aly A. Fahmy , Essam H. Houssein

Positron emission tomography (PET) scans expose patients to radiation, which can be mitigated by reducing the dose, albeit at the cost of diminished quality. This makes low-dose (LD) PET recovery an active research area. Previous studies…

Image and Video Processing · Electrical Eng. & Systems 2026-03-11 Ghulam Nabi Ahmad Hassan Yar , Himashi Peiris , Victoria Mar , Cameron Dennis Pain , Zhaolin Chen

Positron Emission Tomography (PET) image reconstruction is inherently challenged by Poisson noise and physical degradation factors, which are further exacerbated in limited-angle acquisitions. While deep learning methods demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Rüveyda Yilmaz , Yuli Wu , Johannes Stegmaier , Volkmar Schulz

Radiation exposure in positron emission tomography (PET) imaging limits its usage in the studies of radiation-sensitive populations, e.g., pregnant women, children, and adults that require longitudinal imaging. Reducing the PET radiotracer…

Image and Video Processing · Electrical Eng. & Systems 2021-07-22 Viswanath P. Sudarshan , Uddeshya Upadhyay , Gary F. Egan , Zhaolin Chen , Suyash P. Awate

Epilepsy is a neurological disorder and for its detection, encephalography (EEG) is a commonly used clinical approach. Manual inspection of EEG brain signals is a time-consuming and laborious process, which puts heavy burden on neurologists…

Computer Vision and Pattern Recognition · Computer Science 2018-01-17 Ihsan Ullah , Muhammad Hussain , Emad-ul-Haq Qazi , Hatim Aboalsamh

Objective: Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Shaoyan Pan , Elham Abouei , Junbo Peng , Joshua Qian , Jacob F Wynne , Tonghe Wang , Chih-Wei Chang , Justin Roper , Jonathon A Nye , Hui Mao , Xiaofeng Yang