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Background: Dementia, particularly Alzheimer's Disease (AD), is a progressive neurodegenerative disorder marked by cognitive decline. Early detection, especially at the Mild Cognitive Impairment (MCI) stage, is essential for timely…

Signal Processing · Electrical Eng. & Systems 2025-10-16 Shivani Ranjan , Anant Jain , Robin Badal , Amit Kumar , Harshal Shende , Deepak Joshi , Pramod Yadav , Lalan Kumar

Accurate facial expression analysis is an essential step in various clinical applications that involve physical and mental health assessments of older adults (e.g. diagnosis of pain or depression). Although remarkable progress has been…

Computer Vision and Pattern Recognition · Computer Science 2019-05-21 Azin Asgarian , Shun Zhao , Ahmed B. Ashraf , M. Erin Browne , Kenneth M. Prkachin , Alex Mihailidis , Thomas Hadjistavropoulos , Babak Taati

Due to the rapid innovation of technology and the desire to find and employ biomarkers for neurodegenerative disease, high-dimensional data classification problems are routinely encountered in neuroimaging studies. To avoid over-fitting and…

Machine Learning · Statistics 2018-06-19 Shan Shi , Farouk Nathoo

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care to delay further progression. This paper presents the development of a state-of-the-art Conformer based speech recognition system built on the…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Tianzi Wang , Jiajun Deng , Mengzhe Geng , Zi Ye , Shoukang Hu , Yi Wang , Mingyu Cui , Zengrui Jin , Xunying Liu , Helen Meng

In this work, the issue of Parkinson's disease (PD) diagnostics using non-invasive antemortem techniques was tackled. A deep learning approach for classification of raw speech recordings in patients with diagnosed PD was proposed. The core…

Computation and Language · Computer Science 2022-04-28 Maurycy Chronowski , Maciej Klaczynski , Malgorzata Dec-Cwiek , Karolina Porebska

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

Effective and accurate diagnosis of Alzheimer's disease (AD) or mild cognitive impairment (MCI) can be critical for early treatment and thus has attracted more and more attention nowadays. Since first introduced, machine learning methods…

Computer Vision and Pattern Recognition · Computer Science 2014-04-29 Fayao Liu , Chunhua Shen

Alzheimer's disease is a common cognitive disorder in the elderly. Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. At present, researchers have used machine learning…

Sound · Computer Science 2024-02-20 Xiaohui Zhang , Wenjie Fu , Mangui Liang

Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD…

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that progressively impairs memory, decision-making, and overall cognitive function. As AD is irreversible, early prediction is critical for timely intervention and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Mahdieh Behjat Khatooni , Mohsen Soryani

Recent studies have demonstrated that analysis of laboratory-quality voice recordings can be used to accurately differentiate people diagnosed with Parkinson's disease (PD) from healthy controls (HC). These findings could help facilitate…

Applications · Statistics 2019-05-22 Siddharth Arora , Ladan Baghai-Ravary , Athanasios Tsanas

This paper presents our submission to the PROCESS Challenge 2025, focusing on spontaneous speech analysis for early dementia detection. For the three-class classification task (Healthy Control, Mild Cognitive Impairment, and Dementia), we…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-28 Yin-Long Liu , Yuanchao Li , Rui Feng , Liu He , Jia-Xin Chen , Yi-Ming Wang , Yu-Ang Chen , Yan-Han Peng , Jia-Hong Yuan , Zhen-Hua Ling

This study addresses the TAUKADIAL challenge, focusing on the classification of speech from people with Mild Cognitive Impairment (MCI) and neurotypical controls. We conducted three experiments comparing five machine-learning methods:…

Neurons and Cognition · Quantitative Biology 2024-08-30 Cong Zhang , Wenxing Guo , Hongsheng Dai

The human brain can be conceptualized as a dynamical system. Utilizing resting state fMRI time series imaging, we can study the underlying dynamics at ear-marked Regions of Interest (ROIs) to understand structure or lack thereof. This…

Computer Vision and Pattern Recognition · Computer Science 2023-12-01 Ninad Aithal , Chakka Sai Pradeep , Neelam Sinha

Early detection of Alzheimer's disease from spontaneous speech has emerged as a promising non-invasive screening approach. However, the influence of automatic speech recognition (ASR) quality on downstream clinical language modeling remains…

Quantitative Methods · Quantitative Biology 2026-05-01 Himadri S Samanta

Alzheimer's disease is the most common cause of dementia that affects millions of lives worldwide. Investigating the underlying causes and risk factors of Alzheimer's disease is essential to prevent its progression. Mild Cognitive…

Machine Learning · Computer Science 2023-08-22 Deniz Sezin Ayvaz , Inci M. Baytas

This paper describes a multi-modal approach for the automatic detection of Alzheimer's disease proposed in the context of the INESC-ID Human Language Technology Laboratory participation in the ADReSS 2020 challenge. Our classification…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-01 Anna Pompili , Thomas Rolland , Alberto Abad

\textbf{Background:} Machine learning models trained on electronic health records (EHRs) often degrade across healthcare systems due to distributional shift. A fundamental but underexplored factor is diagnostic signal decay: variability in…

Machine Learning · Computer Science 2025-09-11 Jingya Cheng , Jiazi Tian , Federica Spoto , Alaleh Azhir , Daniel Mork , Hossein Estiri

We introduce a novel audio processing architecture, the Open Voice Brain Model (OVBM), improving detection accuracy for Alzheimer's (AD) longitudinal discrimination from spontaneous speech. We also outline the OVBM design methodology…

Sound · Computer Science 2021-11-24 Jordi Laguarta Soler , Brian Subirana

Behavioral and Psychological Symptoms of Dementia (BPSD) impact dementia care substantially, affecting both patients and caregivers. Effective management and early detection of BPSD are crucial to reduce the stress and burden on caregivers…

Signal Processing · Electrical Eng. & Systems 2024-10-25 Benny Wei-Yun Hsu , Yu-Ming Chen , Yuan-Han Yang , Vincent S. Tseng