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Intrasaccular flow disruptors treat cerebral aneurysms by diverting the blood flow from the aneurysm sac. Residual flow into the sac after the intervention is a failure that could be due to the use of an undersized device, or to vascular…
Rupture of intracranial aneurysms results in severe subarachnoidal hemorrhage, which is associated with high morbidity and mortality. Neurointerventional occlusion of the aneurysm through coiling has evolved to a therapeutical standard. The…
Enodvascular coils treat intracranial aneurysms (IAs) by causing them to occlude by thrombosis. Ideally, coiled IAs eventually occlude in the long-term. However, 20.8% are found incompletely occluded at treatment follow-up. Computer…
Endovascular treatment of cerebral aneurysms aims to achieve functional occlusion and isolation of the aneurysm sac from bloodflow. In clinical practice, treatment success is assessed primarily through digital subtraction angiography (DSA),…
Endovascular coil embolization is one of the primary treatment techniques for cerebral aneurysms. Although it is a well established and minimally invasive method, it bears the risk of sub-optimal coil placement which can lead to incomplete…
Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional…
Rapid and accurate simulation of cerebral aneurysm flow modifications by flow diverters (FDs) can help improving patient-specific intervention and predicting treatment outcome. However, with explicit FD devices being placed in…
Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm…
Intracranial aneurysms are the leading cause of hemorrhagic stroke. One of the established treatment approaches is the embolization induced by coil insertion. However, the prediction of treatment and subsequent changed flow characteristics…
Most Computational Fluid Dynamics (CFD) studies of hemodynamics in intracranial aneurysms are based on the assumption of laminar flow due to a relatively low (below 500) parent artery Reynolds number. A few studies have recently…
Flow fluctuations have recently emerged as a promising hemodynamic metric for understanding the rupture risk of intracranial aneurysms. Several investigations have reported in the literature corresponding flow instabilities using…
Human blood flow is a multi-scale problem: in first approximation, blood is a dense suspension of plasma and deformable red cells. Physiological vessel diameters range from about one to thousands of cell radii. Current computational models…
Computational fluid dynamics is intensively used to deepen the understanding of aneurysm growth and rupture in the attempt to support physicians during therapy planning. Numerous studies have assumed fully-rigid vessel walls in their…
Cerebral aneurysms and arteriovenous malformations are life-threatening hemodynamic pathologies of the brain. While surgical intervention is often essential to prevent fatal outcomes, it carries significant risks both during the procedure…
Currently, it is challenging to investigate aneurismal hemodynamics based on current in-vivo data such as Magnetic Resonance Imaging or Computed Tomography due to the limitations in both spatial and temporal resolutions. In this work, we…
Endoluminal reconstruction using flow diverters represents a novel paradigm for the minimally invasive treatment of intracranial aneurysms. The configuration assumed by these very dense braided stents once deployed within the parent vessel…
Intracranial aneurysms (IAs) are serious cerebrovascular lesions found in approximately 5\% of the general population. Their rupture may lead to high mortality. Current methods for assessing IA risk focus on morphological and…
Cardiovascular diseases, specifically cerebral aneurysms, represent a major cause of morbidity and mortality, having a significant impact on the cost and overall status of health care. In the present work, we employ a haemorheological blood…
Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…
Interfacing atomistic-based with continuum-based simulation codes is now required in many multiscale physical and biological systems. We present the first results from coupled atomistic-continuum simulations on 190,000 processors. Platelet…