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In the expanding field of Quantum Computing (QC), efficient and seamless integration of QC and high performance computing (HPC) elements (e.g., quantum hardware, classical hardware, and software infrastructure on both sides) plays a crucial…

Quantum Physics · Physics 2023-09-08 Philipp Seitz , Amr Elsharkawy , Xiao-Ting Michelle To , Martin Schulz

Quantum computing is a promising paradigm that may overcome the current computational power bottlenecks. The increasing maturity of quantum processors provides more possibilities for the development and implementation of quantum algorithms.…

Quantum Physics · Physics 2025-10-15 Ge Yan , Wenjie Wu , Yuheng Chen , Kaisen Pan , Xudong Lu , Zixiang Zhou , Yuhan Wang , Ruocheng Wang , Junchi Yan

The systematic discovery of effective drug combinations is a challenging problem in modern pharmacology, driven by the combinatorial growth of potential pairings and dosage configurations. Network medicine, modeling diseases and drugs as…

Quantum Physics · Physics 2025-12-24 Diogo Ramos , Bruno Coutinho , Duarte Magano

"How to evaluate the de novo designs proposed by a generative model?" Despite the transformative potential of generative deep learning in drug discovery, this seemingly simple question has no clear answer. The absence of standardized…

Biomolecules · Quantitative Biology 2025-11-14 Rıza Özçelik , Francesca Grisoni

Machine learning, particularly graph learning, is gaining increasing recognition for its transformative impact across various fields. One such promising application is in the realm of molecule design and discovery, notably within the…

Machine Learning · Computer Science 2024-01-10 Nianzu Yang , Huaijin Wu , Kaipeng Zeng , Yang Li , Junchi Yan

The rapid progress in quantum computing (QC) and machine learning (ML) has attracted growing attention, prompting extensive research into quantum machine learning (QML) algorithms to solve diverse and complex problems. Designing…

Quantum Physics · Physics 2025-01-13 Samuel Yen-Chi Chen , Huan-Hsin Tseng , Hsin-Yi Lin , Shinjae Yoo

Quantum machine learning has the potential for a transformative impact across industry sectors and in particular in finance. In our work we look at the problem of hedging where deep reinforcement learning offers a powerful framework for…

Learning on small data is a challenge frequently encountered in many real-world applications. In this work we study how effective quantum ensemble models are when trained on small data problems in healthcare and life sciences. We…

Modern cyberattacks are increasingly complex, posing significant challenges to classical machine learning methods, particularly when labeled data is limited and feature interactions are highly non-linear. In this study we investigates the…

Cryptography and Security · Computer Science 2026-01-06 Jessica A. Sciammarelli , Waqas Ahmed

Recent advances in Structure-based Drug Design (SBDD) have leveraged generative models for 3D molecular generation, predominantly evaluating model performance by binding affinity to target proteins. However, practical drug discovery…

Generative adversarial networks (GANs) have achieved remarkable success with realistic tasks such as creating realistic images, texts, and audio. Combining GANs and quantum computing, quantum GANs are thought to have an exponential…

Quantum Physics · Physics 2024-12-04 Haoran Ma , Liao Ye , Fanjie Ruan , Zichao Zhao , Maohui Li , Yuehai Wang , Jianyi Yang

Quantum machine learning consists in taking advantage of quantum computations to generate classical data. A potential application of quantum machine learning is to harness the power of quantum computers for generating classical data, a…

Applying new computing paradigms like quantum computing to the field of machine learning has recently gained attention. However, as high-dimensional real-world applications are not yet feasible to be solved using purely quantum hardware,…

The discovery of functional molecules is an expensive and time-consuming process, exemplified by the rising costs of small molecule therapeutic discovery. One class of techniques of growing interest for early-stage drug discovery is de novo…

Quantitative Methods · Quantitative Biology 2020-02-18 Wenhao Gao , Connor W. Coley

Although the performance of hybrid quantum-classical algorithms is highly dependent on the selection of the classical optimizer and the circuit ansatz, a robust and thorough assessment on-hardware of such features has been missing to date.…

Quantum Physics · Physics 2019-01-24 Vicente Leyton-Ortega , Alejandro Perdomo-Ortiz , Oscar Perdomo

Generative Adversarial Networks (GANs) represent a promising class of generative networks that combine neural networks with game theory. From generating realistic images and videos to assisting musical creation, GANs are transforming many…

Machine Learning · Computer Science 2017-12-04 Alexandre Yahi , Rami Vanguri , Noémie Elhadad , Nicholas P. Tatonetti

Quantum algorithms for simulating large and complex molecular systems are still in their infancy, and surpassing state-of-the-art classical techniques remains an ever-receding goal post. A promising avenue of inquiry in the meanwhile is to…

Quantum Physics · Physics 2025-08-07 Soohaeng Yoo Willow , D. ChangMo Yang , Chang Woo Myung

Uncompetitive antagonists of the N-methyl D-aspartate receptor (NMDAR) have demonstrated therapeutic benefit in the treatment of neurological diseases such as Parkinson's and Alzheimer's, but some also cause dissociative effects that have…

Biomolecules · Quantitative Biology 2021-01-14 Katherine J. Schultz , Sean M. Colby , Yasemin Yesiltepe , Jamie R. Nuñez , Monee Y. McGrady , Ryan R. Renslow

Classical diffusion models have shown superior generative results. Exploring them in the quantum domain can advance the field of quantum generative learning. This work introduces Quantum Generative Diffusion Model (QGDM) as their simple and…

Quantum Physics · Physics 2024-08-06 Chuangtao Chen , Qinglin Zhao , MengChu Zhou , Zhimin He , Zhili Sun , Haozhen Situ

Quantum machine learning has established as an interdisciplinary field to overcome limitations of classical machine learning and neural networks. This is a field of research which can prove that quantum computers are able to solve problems…

Quantum Physics · Physics 2023-03-13 Meghashrita Das , Tirupati Bolisetti