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Generative zero-shot learning (ZSL) methods typically synthesize visual features for unseen classes using predefined semantic attributes, followed by training a fully supervised classification model. While effective, these methods require…

Machine Learning · Computer Science 2025-07-03 Md Shakil Ahamed Shohag , Q. M. Jonathan Wu , Farhad Pourpanah

Cell type annotation is a fundamental step in the analysis of single-cell RNA sequencing (scRNA-seq) data. In practice, human experts often rely on the structure revealed by principal component analysis (PCA) followed by $k$-nearest…

Genomics · Quantitative Biology 2026-02-10 Tianxiang Hu , Chenyi Zhou , Jiaxiang Liu , Jiongxin Wang , Ruizhe Chen , Haoxiang Xia , Gaoang Wang , Jian Wu , Zuozhu Liu

Researchers train neural simulators on uniformly sampled numerical simulation data. But under the same budget, does systematically sampled data provide the most effective information? A fundamental yet unformalized problem is how to sample…

Machine Learning · Computer Science 2026-03-20 Wenshuo Wang , Fan Zhang

Single-cell RNA sequencing (scRNA-seq) technology has profiled hundreds of millions of human cells across organs, diseases, development and perturbations to date. However, the high-dimensional sparsity, batch effect noise, category…

Machine Learning · Computer Science 2025-03-07 Zhen Yu , Jianan Han , Yang Liu , Qingchao Chen

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

When a sample frequency table is published, disclosure risk arises when some individuals can be identified on the basis of their values in certain attributes in the table called key variables, and then their values in other attributes may…

Methodology · Statistics 2009-09-29 Yosef Rinott , Natalie Shlomo

Irregular multivariate time series with missing values present significant challenges for predictive modeling in domains such as healthcare. While deep learning approaches often focus on temporal interpolation or complex architectures to…

Machine Learning · Computer Science 2026-03-16 Dingyi Nie , Yixing Wu , C. -C. Jay Kuo

The dynamic Schr\"odinger bridge problem provides an appealing setting for solving constrained time-series data generation tasks posed as optimal transport problems. It consists of learning non-linear diffusion processes using efficient…

Machine Learning · Computer Science 2023-11-27 Ella Tamir , Martin Trapp , Arno Solin

Irregularly sampled time series (ISTS) data has irregular temporal intervals between observations and different sampling rates between sequences. ISTS commonly appears in healthcare, economics, and geoscience. Especially in the medical…

Machine Learning · Computer Science 2020-10-27 Chenxi Sun , Shenda Hong , Moxian Song , Hongyan Li

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

Quantitative Methods · Quantitative Biology 2016-05-17 Martin Barron , Jun Li

Smoothing Spline ANOVA (SS-ANOVA) models in reproducing kernel Hilbert spaces (RKHS) provide a very general framework for data analysis, modeling and learning in a variety of fields. Discrete, noisy scattered, direct and indirect…

Statistics Theory · Mathematics 2007-06-13 Grace Wahba

This paper deals with a general class of transformation models that contains many important semiparametric regression models as special cases. It develops a self-induced smoothing for the maximum rank correlation estimator, resulting in…

Methodology · Statistics 2013-02-28 Junyi Zhang , Zhezhen Jin , Yongzhao Shao , Zhiliang Ying

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the resolution of individual cells, providing unprecedented insights into cellular heterogeneity and complex biological systems. This paper…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Megha Patel , Nimish Magre , Himanshi Motwani , Nik Bear Brown

Self-supervised learning (SSL) has proven to be a powerful approach for extracting biologically meaningful representations from single-cell data. To advance our understanding of SSL methods applied to single-cell data, we present…

Quantitative Methods · Quantitative Biology 2025-06-13 Olga Ovcharenko , Florian Barkmann , Philip Toma , Imant Daunhawer , Julia Vogt , Sebastian Schelter , Valentina Boeva

Single-cell RNA sequencing (scRNA-seq) data are important for studying the laws of life at single-cell level. However, it is still challenging to obtain enough high-quality scRNA-seq data. To mitigate the limited availability of data,…

Quantitative Methods · Quantitative Biology 2024-03-06 Erpai Luo , Minsheng Hao , Lei Wei , Xuegong Zhang

Given multiple time series data, how can we efficiently find latent patterns in an arbitrary time range? Singular value decomposition (SVD) is a crucial tool to discover hidden factors in multiple time series data, and has been used in many…

Numerical Analysis · Computer Science 2018-12-21 Jun-Gi Jang , Dongjin Choi , Jinhong Jung , U Kang

In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become…

Genomics · Quantitative Biology 2020-01-07 Shixiong Zhang , Xiangtao Li , Qiuzhen Lin , Ka-Chun Wong

Probability density functions form a specific class of functional data objects with intrinsic properties of scale invariance and relative scale characterized by the unit integral constraint. The Bayes spaces methodology respects their…

Methodology · Statistics 2024-05-06 Jana Burkotová , Ivana Pavlů , Hiba Nassar , Jitka Machalová , Karel Hron

Background: Single-cell RNA sequencing (scRNA-seq) yields valuable insights about gene expression and gives critical information about complex tissue cellular composition. In the analysis of single-cell RNA sequencing, the annotations of…

Genomics · Quantitative Biology 2023-03-29 Xiaowen Cao , Li Xing , Elham Majd , Hua He , Junhua Gu , Xuekui Zhang

Zero-Shot Sketch-Based Image Retrieval (ZS-SBIR) is a novel cross-modal retrieval task, where abstract sketches are used as queries to retrieve natural images under zero-shot scenario. Most existing methods regard ZS-SBIR as a traditional…

Computer Vision and Pattern Recognition · Computer Science 2021-06-23 Zhipeng Wang , Hao Wang , Jiexi Yan , Aming Wu , Cheng Deng