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Chemical and biological networks can describe a wide variety of processes, from gene regulatory networks to biochemical oscillations. Modeled by chemical master equations, these processes are inherently stochastic, as fluctuations dominate…

Statistical Mechanics · Physics 2025-12-23 Schuyler B. Nicholson , Luis Pedro García-Pintos

Approximate Bayesian Computation (ABC) provides methods for Bayesian inference in simulation-based stochastic models which do not permit tractable likelihoods. We present a new ABC method which uses probabilistic neural emulator networks to…

Machine Learning · Statistics 2019-05-21 Jan-Matthis Lueckmann , Giacomo Bassetto , Theofanis Karaletsos , Jakob H. Macke

The problem of targeted network immunization can be defined as the one of finding a subset of nodes in a network to immunize or vaccinate in order to minimize a tradeoff between the cost of vaccination and the final (stationary) expected…

Physics and Society · Physics 2015-07-10 F. Altarelli , A. Braunstein , L. Dall'Asta , J. R. Wakeling , R. Zecchina

It is known that describing or calculating the conditional probabilities of multiple events is exponentially expensive. In this work, Bayesian tensor network (BTN) is proposed to efficiently capture the conditional probabilities of multiple…

Machine Learning · Statistics 2020-01-08 Shi-Ju Ran

A classic network tomography problem is estimation of properties of the distribution of route traffic volumes based on counts taken on the network links. We consider inference for a general class of models for integer-valued traffic. Model…

Methodology · Statistics 2015-06-03 Martin L. Hazelton

Black-box optimization methods play an important role in many fields of computational simulation. In particular, such methods are often used in the design and modelling of biological systems, including proteins and their complexes with…

Biomolecules · Quantitative Biology 2023-02-08 Dmitry Morozov , Artem Melnikov , Vishal Shete , Michael Perelshtein

Modeling joint probability distributions over sequences has been studied from many perspectives. The physics community developed matrix product states, a tensor-train decomposition for probabilistic modeling, motivated by the need to…

Machine Learning · Computer Science 2020-10-22 Siddarth Srinivasan , Sandesh Adhikary , Jacob Miller , Guillaume Rabusseau , Byron Boots

When modeling the dynamics of infectious disease, the incorporation of contact network information allows for the capture of the non-randomness and heterogeneity of realistic contact patterns. Oftentimes, it is assumed that the underlying…

Populations and Evolution · Quantitative Biology 2024-04-17 Maxwell H. Wang , Jukka-Pekka Onnela

Joint state and parameter estimation is a core problem for dynamic Bayesian networks. Although modern probabilistic inference toolkits make it relatively easy to specify large and practically relevant probabilistic models, the silver…

Artificial Intelligence · Computer Science 2016-03-31 Yusuf Bugra Erol , Yi Wu , Lei Li , Stuart Russell

In this study, a Bayesian Network (BN) is considered to represent a nuclear plant mechanical system degradation. It describes a causal representation of the phenomena involved in the degradation process. Inference from such a BN needs to…

Methodology · Statistics 2009-05-19 Gilles Celeux , Franck Corset , A. Lannoy , Benoit Ricard

Network topology inference is a fundamental problem in many applications of network science, such as locating the source of fake news, brain connectivity networks detection, etc. Many real-world situations suffer from a critical problem…

Applications · Statistics 2022-06-22 Yupeng Chen , Zhiguo Wang , Xiaojing Shen

A complexity-theoretic approach to studying biological networks is proposed. A simple graph representation is used where molecules (DNA, RNA, proteins and chemicals) are vertices and relations between them are directed and signed…

Social and Information Networks · Computer Science 2018-04-25 Ali Atiia , François Major , Jérôme Waldispühl

We devise a deterministic algorithm to efficiently sample high-quality solutions of certain spin-glass systems that encode hard optimization problems. We employ tensor networks to represent the Gibbs distribution of all possible…

Statistical Mechanics · Physics 2021-09-07 Marek M. Rams , Masoud Mohseni , Daniel Eppens , Konrad Jałowiecki , Bartłomiej Gardas

The network inference problem arises in biological research when one needs to quantitatively choose the best protein-interaction model for explaining a phenotype. The diverse nature of the data and nonlinear dynamics pose significant…

Molecular Networks · Quantitative Biology 2025-12-22 Guy Karlebach

In many real-world scenarios, it is nearly impossible to collect explicit social network data. In such cases, whole networks must be inferred from underlying observations. Here, we formulate the problem of inferring latent social networks…

Social and Information Networks · Computer Science 2010-10-28 Seth A. Myers , Jure Leskovec

Probabilistic inference is a fundamental task in modern machine learning. Recent advances in tensor network (TN) contraction algorithms have enabled the development of better exact inference methods. However, many common inference tasks in…

Machine Learning · Computer Science 2024-09-10 Martin Roa-Villescas , Xuanzhao Gao , Sander Stuijk , Henk Corporaal , Jin-Guo Liu

Modern epidemiological analytics increasingly use machine learning models that offer strong prediction but often lack calibrated uncertainty. Bayesian methods provide principled uncertainty quantification, yet are viewed as difficult to…

Machine Learning · Statistics 2025-11-18 Debashis Chatterjee

Information spreads across social and technological networks, but often the network structures are hidden from us and we only observe the traces left by the diffusion processes, called cascades. Can we recover the hidden network structures…

Social and Information Networks · Computer Science 2014-05-14 Hadi Daneshmand , Manuel Gomez-Rodriguez , Le Song , Bernhard Schoelkopf

A general framework for obtaining exact transition rate matrices for stochastic systems on networks is presented and applied to many well-known compartmental models of epidemiology. The state of the population is described as a vector in…

Populations and Evolution · Quantitative Biology 2021-02-24 Wout Merbis

We give an approximate solution to the difficult inverse problem of inferring the topology of an unknown network from given time-dependent signals at the nodes. For example, we measure signals from individual neurons in the brain, and infer…

Biological Physics · Physics 2021-01-27 Corey Weistuch , Luca Agozzino , Lilianne R. Mujica-Parodi , Ken A. Dill