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Deep learning approaches to breast cancer detection in mammograms have recently shown promising results. However, such models are constrained by the limited size of publicly available mammography datasets, in large part due to privacy…

Computer Vision and Pattern Recognition · Computer Science 2018-08-27 Eric Wu , Kevin Wu , David Cox , William Lotter

While recent computer vision algorithms achieve impressive performance on many benchmarks, they lack robustness - presented with an image from a different distribution, (e.g. weather or lighting conditions not considered during training),…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Sebastian Cygert , Bartłomiej Wróblewski , Karol Woźniak , Radosław Słowiński , Andrzej Czyżewski

Generative molecular design has moved from proof-of-concept to real-world applicability, as marked by the surge in very recent papers reporting experimental validation. Key challenges in explainability and sample efficiency present…

Biomolecules · Quantitative Biology 2024-03-05 Jeff Guo , Philippe Schwaller

Breast cancer (BC) remains a significant global health challenge, with personalized treatment selection complicated by the disease's molecular and clinical heterogeneity. BC treatment decisions rely on various patient-specific clinical…

Applications · Statistics 2025-07-10 Md Nahid Hasan , Md Monzur Murshed , Md Mahadi Hasan , Faysal A. Chowdhury

Interpretability is critical in high-stakes domains such as medical imaging, where understanding model decisions is essential for clinical adoption. In this work, we introduce Sparse Autoencoder (SAE)-based interpretability to breast…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Krishna Kanth Nakka

Unlike classical lexical overlap metrics such as BLEU, most current evaluation metrics for machine translation (for example, COMET or BERTScore) are based on black-box large language models. They often achieve strong correlations with human…

Computation and Language · Computer Science 2024-11-19 Christoph Leiter , Piyawat Lertvittayakumjorn , Marina Fomicheva , Wei Zhao , Yang Gao , Steffen Eger

Breast cancer is considered the most critical and frequently diagnosed cancer in women worldwide, leading to an increase in cancer-related mortality. Early and accurate detection is crucial as it can help mitigate possible threats while…

With the rapid advancements in cancer research, the information that is useful for characterizing disease, staging tumors, and creating treatment and survivorship plans has been changing at a pace that creates challenges when physicians try…

Most pregnancies and births result in a good outcome, but complications are not uncommon and when they do occur, they can be associated with serious implications for mothers and babies. Predictive modeling has the potential to improve…

Motivation : Molecular signatures for diagnosis or prognosis estimated from large-scale gene expression data often lack robustness and stability, rendering their biological interpretation challenging. Increasing the signature's…

Machine Learning · Statistics 2010-01-19 Anne-Claire Haury , Laurent Jacob , Jean-Philippe Vert

Recent advances in a generative neural network model extend the development of data augmentation methods. However, the augmentation methods based on the modern generative models fail to achieve notable performance for class imbalance data…

Machine Learning · Computer Science 2025-07-08 Sungchul Hong , Seunghwan An , Jong-June Jeon

Local Interpretable Model-Agnostic Explanations (LIME) is a popular method to perform interpretability of any kind of Machine Learning (ML) model. It explains one ML prediction at a time, by learning a simple linear model around the…

Machine Learning · Computer Science 2022-02-09 Giorgio Visani , Enrico Bagli , Federico Chesani

Digital mammography is essential to breast cancer detection, and deep learning offers promising tools for faster and more accurate mammogram analysis. In radiology and other high-stakes environments, uninterpretable ("black box") deep…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Julia Yang , Alina Jade Barnett , Jon Donnelly , Satvik Kishore , Jerry Fang , Fides Regina Schwartz , Chaofan Chen , Joseph Y. Lo , Cynthia Rudin

Despite recent advancements in Instruct-based Image Editing models for generating high-quality images, they are known as black boxes and a significant barrier to transparency and user trust. To solve this issue, we introduce SMILE…

Artificial Intelligence · Computer Science 2024-12-24 Zeinab Dehghani , Koorosh Aslansefat , Adil Khan , Adín Ramírez Rivera , Franky George , Muhammad Khalid

Federated learning enables collaborative training of deep learning models across institutions without sharing sensitive patient data. However, its performance is often limited by small datasets and non-independent, identically distributed…

Image and Video Processing · Electrical Eng. & Systems 2026-04-17 Hongyi Pan , Ziliang Hong , Gorkem Durak , Ziyue Xu , Ulas Bagci

Counterfactual explanations (CEs) are a practical tool for demonstrating why machine learning classifiers make particular decisions. For CEs to be useful, it is important that they are easy for users to interpret. Existing methods for…

Machine Learning · Computer Science 2021-03-17 Lisa Schut , Oscar Key , Rory McGrath , Luca Costabello , Bogdan Sacaleanu , Medb Corcoran , Yarin Gal

Breast cancer is a serious disease that inflicts millions of people each year, and the number of cases is increasing. Early detection is the best way to reduce the impact of the disease. Researchers have developed many techniques to detect…

Artificial Intelligence · Computer Science 2023-11-23 Mosab S. M. Farea , zhe chen

High-stakes applications require AI-generated models to be interpretable. Current algorithms for the synthesis of potentially interpretable models rely on objectives or regularization terms that represent interpretability only coarsely…

Machine Learning · Computer Science 2021-04-28 Marco Virgolin , Andrea De Lorenzo , Francesca Randone , Eric Medvet , Mattias Wahde

Deep learning based disease detection and segmentation algorithms promise to improve many clinical processes. However, such algorithms require vast amounts of annotated training data, which are typically not available in the medical context…

Image and Video Processing · Electrical Eng. & Systems 2021-11-02 Moritz Platscher , Jonathan Zopes , Christian Federau

Identifying the mutations that drive cancer growth is key in clinical decision making and precision oncology. As driver mutations confer selective advantage and thus have an increased likelihood of occurrence, frequency-based statistical…

Genomics · Quantitative Biology 2021-05-04 Adnan Akbar , Andrey Solovyev , John W Cassidy , Nirmesh Patel , Harry W Clifford