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Electronic structure simulation (ESS) has been used for decades to provide quantitative scientific insights on an atomistic scale, enabling advances in chemistry, biology, and materials science, among other disciplines. Following standard…

Machine Learning · Computer Science 2024-06-06 Hatem Helal , Andrew Fitzgibbon

Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on…

Biological Physics · Physics 2022-06-22 Harmen Wierenga , Pieter Rein ten Wolde

Concurrent with advancements in molecular communication (MC), bacterial communication is emerging as a key area of interest. Given the frequent use of bacteria in various MC models, it is essential to have a thorough grasp of their…

Signal Processing · Electrical Eng. & Systems 2024-12-18 B. Yagmur Koca , Ozgur B. Akan

During development, cell fates are determined through a combination of intracellular transcriptional regulations and extracellular signaling. As a result, spatial patterns of different cell types arise. We investigate the decision between…

Cell Behavior · Quantitative Biology 2021-11-03 Simon Schardt , Sabine C. Fischer

Living systems are often described utilizing informational analogies. An important open question is whether information is merely a useful conceptual metaphor, or intrinsic to the operation of biological systems. To address this question,…

Molecular Networks · Quantitative Biology 2015-08-19 Hyunju Kim , Paul Davies , Sara Imari Walker

As an effective method to deliver external materials into biological cells, microinjection has been widely applied in the biomedical field. However, the cognition of cell mechanical property is still inadequate, which greatly limits the…

Robotics · Computer Science 2022-11-29 Shengzheng Kang , Zhicheng Song , Xiaolong Yang , Yao Li , Hongtao Wu , Tao Li

In living cells, proteins combine 3D bulk diffusion and 1D sliding along the DNA to reach a target faster. This process is known as facilitated diffusion, and we investigate its dynamics in the physiologically relevant case of confined DNA.…

Soft Condensed Matter · Physics 2015-06-12 G. Foffano , D. Marenduzzo , E. Orlandini

Central to the functioning of a living cell is its ability to control the readout or expression of information encoded in the genome. In many cases, a single transcription factor protein activates or represses the expression of many genes.…

Molecular Networks · Quantitative Biology 2013-05-29 Aleksandra M. Walczak , Gapser Tkacik , William Bialek

Directional chemosensing is ubiquitous in cell biology, but some cells such as mating yeast paradoxically degrade the signal they aim to detect. While the data processing inequality suggests that such signal modification cannot increase the…

Biological Physics · Physics 2023-10-04 Ryan LeFebre , Joseph A. Landsittel , David E. Stone , Andrew Mugler

We define a measure of coherent activity for gene regulatory networks, a property that reflects the unity of purpose between the regulatory agents with a common target. We propose that such harmonious regulatory action is desirable under a…

Quantitative Methods · Quantitative Biology 2015-07-30 Nese Aral , Alkan Kabakcioglu

An evolving yeast colony is simulated by means of a cellular automaton that takes care of many important features of the system under study. A complete survey of the properties of the colony is done and a set of scaling relations is found,…

Statistical Mechanics · Physics 2007-05-23 Lorenzo Fortunato

The design space of networked embedded systems is very large, posing challenges to the optimisation of such platforms when it comes to support applications with real-time guarantees. Recent research has shown that a number of inter-related…

Performance · Computer Science 2020-07-21 Leandro Soares Indrusiak , Robert I. Davis , Piotr Dziurzanski

Collective cell responses to exogenous cues depend on cell-cell interactions. In principle, these can result in enhanced sensitivity to weak and noisy stimuli. However, this has not yet been shown experimentally, and, little is known about…

Traditional studies of memristive devices have mainly focused on their applications in non-volatile information storage and information processing. Here, we demonstrate that the third fundamental component of information technologies { the…

Emerging Technologies · Computer Science 2017-04-26 V. A. Slipko , Y. V. Pershin

Molecular Communication (MC) is a communication strategy that uses molecules as carriers of information, and is widely used by biological cells. As an interdisciplinary topic, it has been studied by biologists, communication theorists and a…

Information Theory · Computer Science 2016-12-13 Amin Gohari , Mahtab Mirmohseni , Masoumeh Nasiri-Kenari

A general theoretical framework is put forth to organize and understand various observed phenomena and mathematical relationships in the field of molecular biology. By modeling each cell in eukaryotic organisms as a processor having a…

Other Quantitative Biology · Quantitative Biology 2013-12-18 Barry D. Jacobson

All living cells interact dynamically with a constantly changing world. Eukaryotes in particular, evolved radically new ways to sense and react to their environment. These advances enabled new and more complex forms of cellular behavior in…

Biological Physics · Physics 2021-02-01 Kirsty Y. Wan , Gáspár Jékely

In the emerging field of molecular communication (MC), testbeds are needed to validate theoretical concepts, motivate applications, and guide further modeling efforts. To this end, this paper presents a flexible and extendable in-vessel…

A conception of mobile edge generation (MEG) is proposed, where generative artificial intelligence (GAI) models are distributed at edge servers (ESs) and user equipment (UE), enabling joint execution of generation tasks. Various distributed…

Networking and Internet Architecture · Computer Science 2024-01-18 Ruikang Zhong , Xidong Mu , Yimeng Zhang , Mona Jabor , Yuanwei Liu

Many biological, physical, and social interactions have a particular dependence on where they take place. In living cells, protein movement between the nucleus and cytoplasm affects cellular response (i.e., proteins must be present in the…

Molecular Networks · Quantitative Biology 2012-10-11 Heather A. Harrington , Elisenda Feliu , Carsten Wiuf , Michael M. P. Stumpf
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