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Several treatments are usually compared with a control using the Dunnett test. As an alternative, three variants of the closed testing approach are considered, one with ANOVA-F-tests, one with MCT-GrandMean and one with global Dunnett-tests…

Applications · Statistics 2020-12-09 Ludwig A. Hothorn

In pharmacogenomic studies, biomedical researchers commonly analyze the association between genotype and biological response by using the Kruskal--Wallis test or one-way analysis of variance (ANOVA) after logarithmic transformation of the…

Methodology · Statistics 2020-12-08 Kengo Nagashima , Yasunori Sato , Chikuma Hamada

We propose a one-to-many matching estimator of the average treatment effect based on propensity scores estimated by isotonic regression. This approach is predicated on the assumption of monotonicity in the propensity score function, a…

Econometrics · Economics 2025-01-27 Mengshan Xu , Taisuke Otsu

System modeling is a classical approach to ensure their reliability since it is suitable both for a formal verification and for software testing techniques. In the context of model-based testing an approach combining random testing and…

Software Engineering · Computer Science 2018-06-14 Julien Bernard , Pierre-Cyrille Héam , Olga Kouchnarenko

The Armitage test for linear trend in proportions can be modified using the multiple marginal model approach for three regression models with arithmetic, ordinal and logarithmic dose scores simultaneously, to be powerful against a wide…

Methodology · Statistics 2020-06-29 Ludwig A. Hothorn , Frank Schaarschmidt

This paper derives the rate of convergence and asymptotic distribution for a class of Kolmogorov-Smirnov style test statistics for conditional moment inequality models for parameters on the boundary of the identified set under general…

Applications · Statistics 2011-12-06 Timothy B. Armstrong

Measures of association play a central role in the social sciences to quantify the strength of a linear relationship between the variables of interest. In many applications researchers can translate scientific expectations to hypotheses…

Methodology · Statistics 2019-04-04 Joris Mulder , John P. T. M. Gelissen

This paper proposes a class of origin-smooth approximators of indicators underlying the sum-of-negative-part statistic for testing multiple inequalities. The need for simulation or bootstrap to obtain test critical values is thereby…

Methodology · Statistics 2012-06-27 Le-Yu Chen , Jerzy Szroeter

Benchmark dose analysis aims to estimate the level of exposure to a toxin that results in a clinically-significant adverse outcome and quantifies uncertainty using the lower limit of a confidence interval for this level. We develop a novel…

Infinite sets of inequalities which generalize all the known inequalities that can be used in the majorization step of the Approximating Hamiltonian method are derived. They provide upper bounds on the difference between the quadratic…

Mathematical Physics · Physics 2011-06-20 J. G. Brankov , N. S. Tonchev

Several application domains require formal but flexible approaches to the comparison problem. Different process models that cannot be related by behavioral equivalences should be compared via a quantitative notion of similarity, which is…

Logic in Computer Science · Computer Science 2010-06-29 Alessandro Aldini

This paper provides general expression for Bartlett and Bartlett-type correction factors for the likelihood ratio and gradient statistics to test the dispersion parameter in heteroscedastic symmetric nonlinear models. This class of…

Statistics Theory · Mathematics 2020-04-24 Mariana C. Araújo , Audrey H. M. A. Cysneiros , Lourdes C. Montenegro

A number of biomedical problems require performing many hypothesis tests, with an attendant need to apply stringent thresholds. Often the data take the form of a series of predictor vectors, each of which must be compared with a single…

Methodology · Statistics 2014-05-13 Yi-Hui Zhou , Fred Wright

Given a stream of Bernoulli random variables, consider the problem of estimating the mean of the random variable within a specified relative error with a specified probability of failure. Until now, the Gamma Bernoulli Approximation Scheme…

Machine Learning · Computer Science 2022-10-25 Mark Huber

The present study defines a new statistic for detecting laboratory effects in the analysis of ordinal variation (ORDANOVA). The ORDANOVA is an analysis method similar to one-way analysis of variance for analysing ordinal data obtained from…

Applications · Statistics 2022-02-10 Jun-ichi Takeshita , Yuto Arai , Mayu Ogawa , Xiao-Nan Lu , Tomomichi Suzuki

The Mann-Kendall test for trend has gained a lot of attention in a range of disciplines, especially in the environmental sciences. One of the drawbacks of the Mann-Kendall test when applied to real data is that no distinction can be made…

Methodology · Statistics 2023-05-24 Stavros Nikolakopoulos , Eric Cator , Mart P. Janssen

We consider Wald's sequential probability ratio test for deciding whether a sequence of independent and identically distributed observations comes from a specified phase-type distribution or from an exponentially tilted alternative…

Probability · Mathematics 2013-07-24 Hansjörg Albrecher , Peiman Asadi , Jevgenijs Ivanovs

Dose groups are compared with a control assuming an order restriction usually by the Williams trend test. Here, as an alternative, two variants of the closed testing procedure are considered, one where global Williams tests are used in the…

Applications · Statistics 2021-01-01 Ludwig A. Hothorn

The Dunnett procedure compares several treatment or dose groups with a control group, while controlling the familywise error rate. When deviations from the normal distribution and heterogeneous variances occur, the nominal $\alpha$ level…

Applications · Statistics 2019-05-07 Ludwig A. Hothorn , Felix M. Kluxen

When there are resource constraints, it is important to rank or estimate treatment benefits according to patient characteristics. This facilitates prioritization of assigning different treatments. Most existing literature on individualized…

Methodology · Statistics 2021-05-05 Muxuan Liang , Menggang Yu