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In this paper, we extend a recently developed machine-learning (ML) based CREASE-2D method to analyze the entire two-dimensional (2D) scattering pattern obtained from small angle X-ray scattering measurements of supramolecular dipeptide…

Soft Condensed Matter · Physics 2025-04-08 Nitant Gupta , Sri V. V. R. Akepati , Simona Bianco , Jay Shah , Dave J. Adams , Arthi Jayaraman

In this paper we present an open-source machine learning (ML) accelerated computational method to analyze small-angle scattering profiles [I(q) vs. q] from concentrated macromolecular solutions to simultaneously obtain the form factor P(q)…

Soft Condensed Matter · Physics 2022-12-07 Christian M. Heil , Yingzhen Ma , Bhuvnesh Bharti , Arthi Jayaraman

Small-angle scattering (SAS) is a key experimental technique for analyzing nano-scale structures in various materials.In SAS data analysis, selecting an appropriate mathematical model for the scattering intensity is critical, as it…

Data Analysis, Statistics and Probability · Physics 2024-01-22 Yui Hayashi , Shun Katakami , Shigeo Kuwamoto , Kenji Nagata , Masaichiro Mizumaki , Masato Okada

Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions. Their relevance has motivated intense research activity seeking to characterize their sequence/structure/function relationships. However, the…

Small-angle scattering (SAS) techniques are indispensable tools for probing the structure of soft materials. However, traditional analytical models often face limitations in structural inversion for complex systems, primarily due to the…

Shape2SAS is a web application that allows researchers and students to build intuition and understanding of small-angle scattering. It is available at https://somo.chem.utk.edu/shape2sas. The user defines a model of arbitrary shape by…

For obtaining reliable nanostructural details of large amounts of sample --- and if it is applicable --- Small-Angle Scattering (SAS) is a prime technique to use. It promises to obtain bulk-scale, statistically sound information on the…

Materials Science · Physics 2013-09-02 Brian Richard Pauw

Integrating sphere (IS) techniques combined with an inverse adding doubling (IAD) algorithm have been widely used for determination of optical properties of ex vivo tissues. Semi-infinite samples are required in such cases. The aim of this…

Small-angle scattering (SAS) techniques, which utilize neutrons and X-rays, are employed in various scientific fields, including materials science, biochemistry, and polymer physics. During the analysis of SAS data, model parameters that…

Small-Angle Scattering (SAS) investigates structures in samples that generally range from approximately 0.5 nm to a few 100 nm. This can both be done for isotropic samples such as blends and liquids, as well as anisotropic samples such as…

Instrumentation and Detectors · Physics 2023-09-22 Sebastian Jaksch

Identifying damage of structural systems is typically characterized as an inverse problem which might be ill-conditioned due to aleatory and epistemic uncertainties induced by measurement noise and modeling error. Sparse representation can…

Applications · Statistics 2020-06-09 Zhao Chen , Hao Sun

Small Angle Scattering (SAS) of X-rays or neutrons is an experimental technique that provides valuable structural information for biological macromolecules under physiological conditions and with no limitation on the molecular size. In…

Biomolecules · Quantitative Biology 2013-06-11 Konstantin Berlin , Nail A. Gumerov , Ramani Duraiswami , David Fushman

In material research, structural characterization often requires multiple complementary techniques to obtain a holistic morphological view of the synthesized material. Depending on the availability of and accessibility of the different…

Soft Condensed Matter · Physics 2023-05-29 Shizhao Lu , Arthi Jayaraman

Small-angle X-ray scattering (SAXS) technique enables convenient nanoscopic characterization for various systems and conditions. Nonetheless, lab-based SAXS systems intrinsically suffer from insufficient x-ray flux and limited angular…

Instrumentation and Detectors · Physics 2020-09-30 Benjamin Gutman , Michael Mrejen , Gil Shabat , Ram Avinery , Yoel Shkolnisky , Roy Beck

Small-angle X-ray or neutron scattering (SAXS/SANS/SAS) is widely used to obtain structural information on biomolecules or soft-matter complexes in solution. Deriving a molecular interpretation of the scattering signals requires methods for…

Biological Physics · Physics 2022-08-16 Leonie Chatzimagas , Jochen S. Hub

Controlling false positives (Type I errors) through statistical hypothesis testing is a foundation of modern scientific data analysis. Existing causal structure discovery algorithms either do not provide Type I error control or cannot scale…

Methodology · Statistics 2025-12-29 James Leiner , Brian Manzo , Aaditya Ramdas , Wesley Tansey

Small angle X-ray scattering (SAXS) is extensively used in materials science as a way of examining nanostructures. The analysis of experimental SAXS data involves mapping a rather simple data format to a vast amount of structural models.…

Machine Learning · Computer Science 2021-11-17 Piotr Tomaszewski , Shun Yu , Markus Borg , Jerk Rönnols

An application of resonant inelastic x-ray scattering technique for studying of optical scale excitations in electron-correlated materials is discussed. Examples are given including data obtained for 3d transition metal, lanthanide, and…

Strongly Correlated Electrons · Physics 2007-05-23 Sergei M. Butorin

Contrast variation small-angle neutron scattering (CV-SANS) is a powerful tool to evaluate the structure of multi-component systems by decomposing scattering intensities $I$ measured with different scattering contrasts into partial…

Soft Condensed Matter · Physics 2025-03-25 Koichi Mayumi , Tatsuro Oda , Shinya Miyajima , Ippei Obayashi , Kazuaki Tanaka

Resolution smearing is a critical challenge in the quantitative analysis of two-dimensional small-angle neutron scattering (SANS) data, particularly in studies of soft matter flow and deformation using SANS. We present the central moment…

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