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By composing graphical models with deep learning architectures, we learn generative models with the strengths of both frameworks. The structured variational autoencoder (SVAE) inherits structure and interpretability from graphical models,…

Machine Learning · Computer Science 2023-11-15 Harry Bendekgey , Gabriel Hope , Erik B. Sudderth

Learning interpretable and disentangled representations of data is a key topic in machine learning research. Variational Autoencoder (VAE) is a scalable method for learning directed latent variable models of complex data. It employs a clear…

Machine Learning · Computer Science 2020-06-04 Andriy Serdega , Dae-Shik Kim

Deep learning (DL) methods where interpretability is intrinsically considered as part of the model are required to better understand the relationship of clinical and imaging-based attributes with DL outcomes, thus facilitating their use in…

Image and Video Processing · Electrical Eng. & Systems 2022-12-13 Irem Cetin , Maialen Stephens , Oscar Camara , Miguel Angel Gonzalez Ballester

To achieve high-levels of autonomy, modern robots require the ability to detect and recover from anomalies and failures with minimal human supervision. Multi-modal sensor signals could provide more information for such anomaly detection…

Robotics · Computer Science 2020-12-17 Tianchen Ji , Sri Theja Vuppala , Girish Chowdhary , Katherine Driggs-Campbell

Learning interpretable latent representations from tabular data remains a challenge in deep generative modeling. We introduce SE-VAE (Structural Equation-Variational Autoencoder), a novel architecture that embeds measurement structure…

Machine Learning · Computer Science 2025-08-19 Ruiyu Zhang , Ce Zhao , Xin Zhao , Lin Nie , Wai-Fung Lam

Cancer is a heterogeneous disease with diverse molecular etiologies and outcomes. The Cancer Genome Atlas (TCGA) has released a large compendium of over 10,000 tumors with RNA-seq gene expression measurements. Gene expression captures the…

Genomics · Quantitative Biology 2017-11-15 Gregory P. Way , Casey S. Greene

The discovery of new materials is often constrained by the need for large labelled datasets or expensive simulations. In this study, we explore the use of Disentangling Autoencoders (DAEs) to learn compact and interpretable representations…

Materials Science · Physics 2025-07-29 Jaehoon Cha , Tingyao Lu , Matthew Walker , Keith T. Butler

Representation learning seeks to expose certain aspects of observed data in a learned representation that's amenable to downstream tasks like classification. For instance, a good representation for 2D images might be one that describes only…

Machine Learning · Computer Science 2017-03-07 Xi Chen , Diederik P. Kingma , Tim Salimans , Yan Duan , Prafulla Dhariwal , John Schulman , Ilya Sutskever , Pieter Abbeel

Unsupervised representation learning holds the promise of exploiting large amounts of unlabeled data to learn general representations. A promising technique for unsupervised learning is the framework of Variational Auto-encoders (VAEs).…

Computer Vision and Pattern Recognition · Computer Science 2020-04-09 Kamal Gupta , Saurabh Singh , Abhinav Shrivastava

Unsupervised anomaly detection could be crucial in future analyses searching for rare phenomena in large datasets, as for example collected at the LHC. To this end, we introduce a physics inspired variational autoencoder (VAE) architecture…

High Energy Physics - Phenomenology · Physics 2022-06-08 Blaž Bortolato , Barry M. Dillon , Jernej F. Kamenik , Aleks Smolkovič

With the ever-increasing amount of data, the central challenge in multimodal learning involves limitations of labelled samples. For the task of classification, techniques such as meta-learning, zero-shot learning, and few-shot learning…

Computer Vision and Pattern Recognition · Computer Science 2021-06-29 Nihar Bendre , Kevin Desai , Peyman Najafirad

We apply variational autoencoders (VAE) to X-ray diffraction (XRD) data analysis on both simulated and experimental thin-film data. We show that crystal structure representations learned by a VAE reveal latent information, such as the…

Materials Science · Physics 2021-04-12 Lars Banko , Phillip M. Maffettone , Dennis Naujoks , Daniel Olds , Alfred Ludwig

Estimation of uncertainty in deep learning models is of vital importance, especially in medical imaging, where reliance on inference without taking into account uncertainty could lead to misdiagnosis. Recently, the probabilistic Variational…

Machine Learning · Computer Science 2020-10-20 Haleh Akrami , Anand A. Joshi , Sergul Aydore , Richard M. Leahy

Density estimation, compression and data generation are crucial tasks in artificial intelligence. Variational Auto-Encoders (VAEs) constitute a single framework to achieve these goals. Here, we present a novel class of generative models,…

Machine Learning · Statistics 2021-07-07 Ioannis Gatopoulos , Jakub M. Tomczak

While transformers have surpassed convolutional neural networks (CNNs) in various computer vision tasks, microelectronics defect detection still largely relies on CNNs. We hypothesize that this gap is due to the fact that a) transformers…

Computer Vision and Pattern Recognition · Computer Science 2025-08-13 Nikolai Röhrich , Alwin Hoffmann , Richard Nordsieck , Emilio Zarbali , Alireza Javanmardi

We investigate methods of microstructure representation for the purpose of predicting processing condition from microstructure image data. A binary alloy (uranium-molybdenum) that is currently under development as a nuclear fuel was studied…

We introduce a Deep Kernel Learning Variational Autoencoder (VAE-DKL) framework that integrates the generative power of a Variational Autoencoder (VAE) with the predictive nature of Deep Kernel Learning (DKL). The VAE learns a latent…

Machine Learning · Computer Science 2025-03-06 Boris N. Slautin , Utkarsh Pratiush , Doru C. Lupascu , Maxim A. Ziatdinov , Sergei V. Kalinin

Biological sequence design (DNA, RNA, or peptides) with desired functional properties has applications in discovering novel nanomaterials, biosensors, antimicrobial drugs, and beyond. One common challenge is the ability to optimize complex…

Quantitative Methods · Quantitative Biology 2025-12-17 Elham Sadeghi , Xianqi Deng , I-Hsin Lin , Stacy M. Copp , Petko Bogdanov

Learning a robust Variational Autoencoder (VAE) is a fundamental step for many deep learning applications in medical image analysis, such as MRI synthesizes. Existing brain VAEs predominantly focus on single-modality data (i.e., T1-weighted…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Mingjie Li , Edward Kim , Yue Zhao , Ehsan Adeli , Kilian M. Pohl

Sparse autoencoders (SAEs) have recently become central tools for interpretability, leveraging dictionary learning principles to extract sparse, interpretable features from neural representations whose underlying structure is typically…

Machine Learning · Computer Science 2025-11-05 Valérie Costa , Thomas Fel , Ekdeep Singh Lubana , Bahareh Tolooshams , Demba Ba
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