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Purpose: Immunotherapies have revolutionized the landscape of cancer treatments. However, our understanding of response patterns in advanced cancers treated with immunotherapy remains limited. By leveraging routinely collected noninvasive…

We propose a hybrid sequential deep learning model to predict the risk of AMD progression in non-exudative AMD eyes at multiple timepoints, starting from short-term progression (3-months) up to long-term progression (21-months). Proposed…

Quantitative Methods · Quantitative Biology 2019-03-01 Imon Banerjee , Luis de Sisternes , Joelle Hallak , Theodore Leng , Aaron Osborne , Mary Durbin , Daniel Rubin

In this study, we present a deep learning framework that learns complex spatio-temporal correlation structures of EEG signals through a Spatio-Temporal Attention Network (STAN) for accurate predictions of onset of seizures for Epilepsy…

Signal Processing · Electrical Eng. & Systems 2025-11-06 Zan Li , Kyongmin Yeo , Wesley Gifford , Lara Marcuse , Madeline Fields , Bülent Yener

Deep State Space Models (SSMs) have proven effective in numerous task scenarios but face significant security challenges due to Adversarial Perturbations (APs) in real-world deployments. Adversarial Training (AT) is a mainstream approach to…

Machine Learning · Computer Science 2024-10-10 Biqing Qi , Yang Luo , Junqi Gao , Pengfei Li , Kai Tian , Zhiyuan Ma , Bowen Zhou

Long-term adherence to medication is a critical factor in preventing chronic diseases, such as cardiovascular disease. To address poor adherence, physicians may recommend adherence-improving interventions; however, such interventions are…

Optimization and Control · Mathematics 2026-02-24 Daniel Otero-Leon , Mariel Lavieri , Brian Denton , Jeremy Sussman , Rodney Hayward

With the increased availability of large databases of electronic health records (EHRs) comes the chance of enhancing health risks screening. Most post-marketing detections of adverse drug reaction (ADR) rely on physicians' spontaneous…

Applications · Statistics 2018-01-29 Maryan Morel , Emmanuel Bacry , Stéphane Gaïffas , Agathe Guilloux , Fanny Leroy

Sequential recommendation (SR) models often capture user preferences based on the historically interacted item IDs, which usually obtain sub-optimal performance when the interaction history is limited. Content-based sequential…

Information Retrieval · Computer Science 2025-10-20 Donglin Zhou , Weike Pan , Zhong Ming

Purpose: To examine whether incorporating anatomical awareness into a deep learning model can improve generalizability and enable prediction of disease progression. Methods: This retrospective multicenter study included conventional pelvic…

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

In recent years, the success of large language models (LLMs) has driven the exploration of scaling laws in recommender systems. However, models that demonstrate scaling laws are actually challenging to deploy in industrial settings for…

Information Retrieval · Computer Science 2026-01-27 Weijiang Lai , Beihong Jin , Di Zhang , Siru Chen , Jiongyan Zhang , Yuhang Gou , Jian Dong , Xingxing Wang

Purpose. Elevations in initially obtained serum lactate levels are strong predictors of mortality in critically ill patients. Identifying patients whose serum lactate levels are more likely to increase can alert physicians to intensify care…

Quantitative Methods · Quantitative Biology 2021-07-19 Behrooz Mamandipoor , Wesley Yeung , Louis Agha-Mir-Salim , David J. Stone , Venet Osmani , Leo Anthony Celi

Reinforcement Learning (RL) has recently been applied to sequential estimation and prediction problems identifying and developing hypothetical treatment strategies for septic patients, with a particular focus on offline learning with…

Machine Learning · Computer Science 2020-11-24 Taylor W. Killian , Haoran Zhang , Jayakumar Subramanian , Mehdi Fatemi , Marzyeh Ghassemi

Sequence modeling faces challenges in capturing long-range dependencies across diverse tasks. Recent linear and transformer-based forecasters have shown superior performance in time series forecasting. However, they are constrained by their…

Machine Learning · Computer Science 2024-11-25 Bong Gyun Kang , Dongjun Lee , HyunGi Kim , DoHyun Chung , Sungroh Yoon

Confounding bias and selection bias bring two significant challenges to the validity of conclusions drawn from applied causal inference. The latter can stem from informative missingness, such as in cases of attrition. We introduce the…

Methodology · Statistics 2025-03-25 Johan de Aguas , Johan Pensar , Tomás Varnet Pérez , Guido Biele

Deep reinforcement learning (RL) algorithms can use high-capacity deep networks to learn directly from image observations. However, these high-dimensional observation spaces present a number of challenges in practice, since the policy must…

Machine Learning · Computer Science 2020-10-27 Alex X. Lee , Anusha Nagabandi , Pieter Abbeel , Sergey Levine

This paper presents an overview and evaluation of some of the end-to-end ASR models on long-form audios. We study three categories of Automatic Speech Recognition(ASR) models based on their core architecture: (1) convolutional, (2)…

Audio and Speech Processing · Electrical Eng. & Systems 2023-09-22 Nithin Rao Koluguri , Samuel Kriman , Georgy Zelenfroind , Somshubra Majumdar , Dima Rekesh , Vahid Noroozi , Jagadeesh Balam , Boris Ginsburg

Non-adherence to medications is a critical concern since nearly half of patients with chronic illnesses do not follow their prescribed medication regimens, leading to increased mortality, costs, and preventable human distress. Amongst stage…

Machine Learning · Computer Science 2025-04-22 Navreet Kaur , Manuel Gonzales , Cristian Garcia Alcaraz , Jiaqi Gong , Kristen J. Wells , Laura E. Barnes

Computational cytology faces two major challenges: i) instance-level labels are unreliable and prohibitively costly to obtain, ii) witness rates are extremely low. We propose SLAM-AGS, a Slide-Label-Aware Multitask pretraining framework…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Marco Acerbis , Swarnadip Chatterjee , Christophe Avenel , Joakim Lindblad

Sequential recommendation is a key area in the field of recommendation systems aiming to model user interest based on historical interaction sequences with irregular intervals. While previous recurrent neural network-based and…

Information Retrieval · Computer Science 2025-12-08 Wei Xiao , Huiying Wang , Qifeng Zhou , Qing Wang

This paper introduces an R package SensIAT that implements a sensitivity analysis methodology, based on augmented inverse intensity weighting, for randomized trials with irregular and potentially informative assessment times. Targets of…