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The fundamental biological processes of development of tissues and organs in multicellular organisms is governed by various signaling molecules, which are called morphogens. It is known that spatial and temporal variations in concentration…

Biological Physics · Physics 2015-04-07 Behnaz Bozorgui , Hamid Teimouri , Anatoly B. Kolomeisky

Understanding and predicting the progression of neurodegenerative diseases remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning. However, most available…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Nivetha Jayakumar , Swakshar Deb , Bahram Jafrasteh , Qingyu Zhao , Miaomiao Zhang

Molecular generation plays an important role in drug discovery and materials science, especially in data-scarce scenarios where traditional generative models often struggle to achieve satisfactory conditional generalization. To address this…

Machine Learning · Computer Science 2025-05-13 Zimo Yan , Jie Zhang , Zheng Xie , Chang Liu , Yizhen Liu , Yiping Song

Graph generation is a crucial task in many fields, including network science and bioinformatics, as it enables the creation of synthetic graphs that mimic the properties of real-world networks for various applications. Graph Generative…

Machine Learning · Computer Science 2026-01-21 Salvatore Romano , Marco Grassia , Giuseppe Mangioni

Deep learning algorithms for connectomics rely upon localized classification, rather than overall morphology. This leads to a high incidence of erroneously merged objects. Humans, by contrast, can easily detect such errors by acquiring…

Computer Vision and Pattern Recognition · Computer Science 2017-06-01 David Rolnick , Yaron Meirovitch , Toufiq Parag , Hanspeter Pfister , Viren Jain , Jeff W. Lichtman , Edward S. Boyden , Nir Shavit

Molecule generation is a challenging open problem in cheminformatics. Currently, deep generative approaches addressing the challenge belong to two broad categories, differing in how molecules are represented. One approach encodes molecular…

Machine Learning · Statistics 2020-11-02 Marco Podda , Davide Bacciu , Alessio Micheli

Simulating urban morphology with location attributes is a challenging task in urban science. Recent studies have shown that Generative Adversarial Networks (GANs) have the potential to shed light on this task. However, existing GAN-based…

Computers and Society · Computer Science 2022-07-07 Weiyu Zhang , Yiyang Ma , Di Zhu , Lei Dong , Yu Liu

Gigapixel medical images provide massive data, both morphological textures and spatial information, to be mined. Due to the large data scale in histology, deep learning methods play an increasingly significant role as feature extractors.…

Image and Video Processing · Electrical Eng. & Systems 2022-06-16 Yiqing Shen , Bingxin Zhou , Xinye Xiong , Ruitian Gao , Yu Guang Wang

We describe a layer-by-layer algorithm for training deep convolutional networks, where each step involves gradient updates for a two layer network followed by a simple clustering algorithm. Our algorithm stems from a deep generative model…

Machine Learning · Computer Science 2018-06-26 Eran Malach , Shai Shalev-Shwartz

Graph foundation models represent a transformative paradigm for learning transferable representations across diverse graph domains. Recent methods leverage large language models to unify graph and text modalities into a shared…

Machine Learning · Computer Science 2025-12-23 Heng Zhang , Tianyi Zhang , Yuling Shi , Xiaodong Gu , Yaomin Shen , Haochen You , Zijian Zhang , Yilei Yuan , Jin Huang

Accurately modeling multi-class cell topology is crucial in digital pathology, as it provides critical insights into tissue structure and pathology. The synthetic generation of cell topology enables realistic simulations of complex tissue…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Meilong Xu , Saumya Gupta , Xiaoling Hu , Chen Li , Shahira Abousamra , Dimitris Samaras , Prateek Prasanna , Chao Chen

Identity-preserving face synthesis aims to generate synthetic face images of virtual subjects that can substitute real-world data for training face recognition models. While prior arts strive to create images with consistent identities and…

Computer Vision and Pattern Recognition · Computer Science 2025-04-02 Yuxi Mi , Zhizhou Zhong , Yuge Huang , Qiuyang Yuan , Xuan Zhao , Jianqing Xu , Shouhong Ding , ShaoMing Wang , Rizen Guo , Shuigeng Zhou

It is often the case that the performance of a neural network can be improved by adding layers. In real-world practices, we always train dozens of neural network architectures in parallel which is a wasteful process. We explored $CompNet$,…

Neural and Evolutionary Computing · Computer Science 2018-04-30 Jun Lu , Wei Ma , Boi Faltings

Drug discovery is a complex, resource-intensive process requiring significant time and cost to bring new medicines to patients. Many generative models aim to accelerate drug discovery, but few produce synthetically accessible molecules.…

Machine Learning · Computer Science 2025-01-30 Zygimantas Jocys , Zhanxing Zhu , Henriette M. G. Willems , Katayoun Farrahi

Synthesizing geometrical shapes from human brain activities is an interesting and meaningful but very challenging topic. Recently, the advancements of deep generative models like Generative Adversarial Networks (GANs) have supported the…

Signal Processing · Electrical Eng. & Systems 2020-03-02 Xiang Zhang , Xiaocong Chen , Manqing Dong , Huan Liu , Chang Ge , Lina Yao

Sound morphing is the process of gradually and smoothly transforming one sound into another to generate novel and perceptually hybrid sounds that simultaneously resemble both. Recently, diffusion-based text-to-audio models have produced…

Audio and Speech Processing · Electrical Eng. & Systems 2024-08-15 Purnima Kamath , Chitralekha Gupta , Suranga Nanayakkara

Generating cognitive-aligned layered SVGs remains challenging due to existing methods' tendencies toward either oversimplified single-layer outputs or optimization-induced shape redundancies. We propose LayerTracer, a diffusion transformer…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Yiren Song , Danze Chen , Mike Zheng Shou

Neural Cellular Automata (NCA) have shown a remarkable ability to learn the required rules to "grow" images, classify morphologies, segment images, as well as to do general computation such as path-finding. We believe the inductive prior…

Artificial Intelligence · Computer Science 2021-05-18 Alexander Mordvintsev , Eyvind Niklasson , Ettore Randazzo

In common real-world robotic operations, action and state spaces can be vast and sometimes unknown, and observations are often relatively sparse. How do we learn the full topology of action and state spaces when given only few and sparse…

Machine Learning · Computer Science 2019-07-16 Lingzhi Zhang , Andong Cao , Rui Li , Jianbo Shi

Traditional gradient boosting algorithms employ static tree structures with fixed splitting criteria that remain unchanged throughout training, limiting their ability to adapt to evolving gradient distributions and problem-specific…

Machine Learning · Computer Science 2025-11-18 Boris Kriuk