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Data scarcity, bias, and experimental noise are all frequently encountered problems in the application of deep learning to chemical and material science disciplines. Transfer learning has proven effective in compensating for the lack in…

Chemical Physics · Physics 2021-03-16 Florence H. Vermeire , William H. Green

Obtaining the exciton dynamics of large photosynthetic complexes by using mixed quantum mechanics/molecular mechanics (QM/MM) is computationally demanding. We propose a machine learning technique, multi-layer perceptrons, as a tool to…

Chemical Physics · Physics 2016-06-01 Florian Häse , Stéphanie Valleau , Edward Pyzer-Knapp , Alán Aspuru-Guzik

Recent experimental breakthroughs have signalled the imminent arrival of the early fault-tolerant era. However, for a considerable period in the foreseeable future, relying solely on quantum error correction for full error suppression will…

Quantum Physics · Physics 2025-02-18 Kecheng Liu , Zhenyu Cai

The accuracy of any machine learning potential can only be as good as the data used in the fitting process. The most efficient model therefore selects the training data that will yield the highest accuracy compared to the cost of obtaining…

Chemical Physics · Physics 2020-07-21 Anders S. Christensen , O. Anatole von Lilienfeld

Quantum error correction (QEC) is essential for scalable quantum computing. However, it requires classical decoders that are fast and accurate enough to keep pace with quantum hardware. While quantum low-density parity-check codes have…

Quantum Physics · Physics 2026-04-10 Andi Gu , J. Pablo Bonilla Ataides , Mikhail D. Lukin , Susanne F. Yelin

Quantum error correction is widely thought to be the key to fault-tolerant quantum computation. However, determining the most suited encoding for unknown error channels or specific laboratory setups is highly challenging. Here, we present a…

This is a comprehensive review on fault-tolerant topological quantum computation with the surface codes. The basic concepts and useful tools underlying fault-tolerant quantum computation, such as universal quantum computation, stabilizer…

Quantum Physics · Physics 2015-04-08 Keisuke Fujii

With gate error rates in multiple technologies now below the threshold required for fault-tolerant quantum computation, the major remaining obstacle to useful quantum computation is scaling, a challenge greatly amplified by the huge…

Quantum Physics · Physics 2021-12-09 Kianna Wan , Soonwon Choi , Isaac H. Kim , Noah Shutty , Patrick Hayden

Efficient and accurate decoding of quantum error-correcting codes is essential for fault-tolerant quantum computation, however, it is challenging due to the degeneracy of errors, the complex code topology, and the large space for logical…

Quantum Physics · Physics 2025-03-28 Hanyan Cao , Feng Pan , Dongyang Feng , Yijia Wang , Pan Zhang

Simulations of biological macromolecules play an important role in understanding the physical basis of a number of complex processes such as protein folding. Even with increasing computational power and evolution of specialized…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-09-18 Hyungro Lee , Heng Ma , Matteo Turilli , Debsindhu Bhowmik , Shantenu Jha , Arvind Ramanathan

Quantum mechanics/molecular mechanics (QM/MM) molecular dynamics (MD) simulations have been developed to simulate molecular systems, where an explicit description of changes in the electronic structure is necessary. However, QM/MM MD…

Chemical Physics · Physics 2021-04-15 Lennard Böselt , Moritz Thürlemann , Sereina Riniker

Recently Shor showed how to perform fault tolerant quantum computation when the error probability is logarithmically small. We improve this bound and describe fault tolerant quantum computation when the error probability is smaller than…

Quantum Physics · Physics 2008-02-03 Dorit Aharonov , Michael Ben-Or

Computational prediction of enzyme mechanism and protein function requires accurate physics-based models and suitable sampling. We discuss recent advances in large-scale quantum mechanical (QM) modeling of biochemical systems that have…

Chemical Physics · Physics 2021-05-28 Vyshnavi Vennelakanti , Azadeh Nazemi , Rimsha Mehmood , Adam H. Steeves , Heather J. Kulik

Sampling from known probability distributions is a ubiquitous task in computational science, underlying calculations in domains from linguistics to biology and physics. Generative machine-learning (ML) models have emerged as a promising…

High Energy Physics - Lattice · Physics 2023-09-06 Kyle Cranmer , Gurtej Kanwar , Sébastien Racanière , Danilo J. Rezende , Phiala E. Shanahan

The accurate but fast calculation of molecular excited states is still a very challenging topic. For many applications, detailed knowledge of the energy funnel in larger molecular aggregates is of key importance requiring highly accurate…

Chemical Physics · Physics 2024-01-12 Vivin Vinod , Sayan Maity , Peter Zaspel , Ulrich Kleinekathöfer

The prediction of product translational, vibrational, and rotational energy distributions for arbitrary initial conditions for reactive atom+diatom collisions is of considerable practical interest in atmospheric re-entry. Due to the large…

Chemical Physics · Physics 2023-06-23 Juan Carlos San Vicente Veliz , Julian Arnold , Raymond J. Bemish , Markus Meuwly

Color code is a promising topological code for fault-tolerant quantum computing. Insufficient research on the color code has delayed its practical application. In this work, we address several key issues to facilitate practical…

Quantum Physics · Physics 2024-06-04 Jiaxuan Zhang , Yu-Chun Wu , Guo-Ping Guo

In this paper we extend both standard fault tolerance theory and Kitaev's model for quantum computation, combining them so as to yield quantitative results that reveal the interplay between the two. Our analysis establishes a methodology…

Quantum Physics · Physics 2007-07-03 Gerald Gilbert , Michael Hamrick , Yaakov S. Weinstein

Quantum Computing (QC) offers outstanding potential for molecular characterization and drug discovery, particularly in solving complex properties like the Ground State Energy (GSE) of biomolecules. However, QC faces challenges due to…

Chemical Physics · Physics 2024-12-17 Laia Coronas Sala , Parfait Atchade-Adelemou

We investigate the feasibility of early fault-tolerant quantum algorithms focusing on ground-state energy estimation problems. In particular, we examine the computation of the cumulative distribution function (CDF) of the spectral measure…