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In this study, we propose a new method for constrained combinatorial optimization using variational quantum circuits. Quantum computers are considered to have the potential to solve large combinatorial optimization problems faster than…

Quantum Physics · Physics 2025-07-15 Hyakka Nakada , Kotaro Tanahashi , Shu Tanaka

Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels

Quantum computing provides powerful algorithmic tools that have been shown to outperform established classical solvers in specific optimization tasks. A core step in solving optimization problems with known quantum algorithms such as the…

In the search for quantum advantage with near-term quantum devices, navigating the optimization landscape is significantly hampered by the barren plateaus phenomenon. This study presents a strategy to overcome this obstacle without changing…

Quantum Physics · Physics 2025-03-11 Yuhan Yao , Yoshihiko Hasegawa

Quantum computing is a computational paradigm with the potential to outperform classical methods for a variety of problems. Proposed recently, the Quantum Approximate Optimization Algorithm (QAOA) is considered as one of the leading…

Machine Learning · Computer Science 2022-06-16 Sami Khairy , Ruslan Shaydulin , Lukasz Cincio , Yuri Alexeev , Prasanna Balaprakash

Gate model quantum computers with too many qubits to be simulated by available classical computers are about to arrive. We present a strategy for programming these devices without error correction or compilation. This means that the number…

Quantum Physics · Physics 2017-03-21 E. Farhi , J. Goldstone , S. Gutmann , H. Neven

Algorithms based on non-unitary evolution have attracted much interest for ground state preparation on quantum computers. One recently proposed method makes use of ancilla qubits and controlled unitary operators to implement weak…

Quantum Physics · Physics 2025-12-25 Tobias Stollenwerk , Stuart Hadfield

We design a variational quantum algorithm to solve multi-dimensional Poisson equations with mixed boundary conditions that are typically required in various fields of computational science. Employing an objective function that is formulated…

Quantum Physics · Physics 2025-05-26 Minjin Choi , Hoon Ryu

This work studies the variational quantum eigensolver algorithm, designed to determine the ground state of a quantum mechanical system by combining classical and quantum hardware. Methods of reducing the number of required qubit…

Quantum Physics · Physics 2022-03-01 R. J. P. T. de Keijzer , V. E. Colussi , B. Škorić , S. J. J. M. F. Kokkelmans

Solving atomic nuclei from first principles places enormous demands on computational resources, which grow exponentially with increasing number of particles and the size of the space they occupy. We present first quantum simulations based…

Digital quantum simulation of electron-phonon systems requires truncating infinite phonon levels into $N$ basis states and then encoding them with qubit computational basis. Unary encoding and the more compact binary/Gray encoding are the…

Quantum Physics · Physics 2023-05-04 Weitang Li , Jiajun Ren , Sainan Huai , Tianqi Cai , Zhigang Shuai , Shengyu Zhang

Combinatorial optimization on near-term quantum devices is a promising path to demonstrating quantum advantage. However, the capabilities of these devices are constrained by high noise or error rates. In this paper, we propose an iterative…

Quantum Physics · Physics 2022-05-12 Xiaoyuan Liu , Anthony Angone , Ruslan Shaydulin , Ilya Safro , Yuri Alexeev , Lukasz Cincio

The state-of-the-art quantum computing hardware has entered the noisy intermediate-scale quantum (NISQ) era. Having been constrained by the limited number of qubits and shallow circuit depth, NISQ devices have nevertheless demonstrated the…

Quantum Physics · Physics 2022-06-23 Guanglei Xu , Yi-Bin Guo , Xuan Li , Zong-Sheng Zhou , Hai-Jun Liao , T. Xiang

The advent of quantum computing processors with possibility to scale beyond experimental capacities magnifies the importance of studying their applications. Combinatorial optimization problems can be one of the promising applications of…

Quantum Physics · Physics 2017-08-18 Ehsan Zahedinejad , Arman Zaribafiyan

We develop a global variable substitution method that reduces $n$-variable monomials in combinatorial optimization problems to equivalent instances with monomials in fewer variables. We apply this technique to $3$-SAT and analyze the…

The ability of the Quantum Approximate Optimization Algorithm (QAOA) to deliver a quantum advantage on combinatorial optimization problems is still unclear. Recently, a scaling advantage over a classical solver was postulated to exist for…

Quantum Physics · Physics 2024-12-02 Thorge Müller , Ajainderpal Singh , Frank K. Wilhelm , Tim Bode

We consider the problem of optimizing a multivariate quadratic function where each decision variable is constrained to be a complex $m$'th root of unity. Such problems have applications in signal processing, MIMO detection, and the…

Optimization and Control · Mathematics 2025-08-05 Ahmad Al-Sulami , Hamza Fawzi , Shengding Sun

Quantum processors promise a paradigm shift in high-performance computing which needs to be assessed by accurate benchmarking measures. In this work, we introduce a new benchmark for variational quantum algorithm (VQA), recently proposed as…

Quantum Physics · Physics 2018-05-09 Walter Vinci , Alireza Shabani

Recent hardware demonstrations and advances in circuit compilation have made quantum computing with higher-dimensional systems (qudits) on near-term devices an attractive possibility. Some problems have more natural or optimal encodings…

Quantum Physics · Physics 2023-08-17 Gabriel Bottrill , Mudit Pandey , Olivia Di Matteo

Solving combinatorial optimization problems of the kind that can be codified by quadratic unconstrained binary optimization (QUBO) is a promising application of quantum computation. Some problems of this class suitable for practical…