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Alzheimer s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, where early detection is essential for timely intervention and improved patient outcomes. Traditional diagnostic methods are…

Alzheimer disease (AD) is a neurodegenerative disease that lacks specific treatment options. Natural drugs have displayed neuroprotective effects; however, their high-throughput discovery is challenging because of the expense of…

Other Quantitative Biology · Quantitative Biology 2026-04-28 Hafiza Syeda Yusra Tirmizi , Syed Ibad Hasnain , Muhammad Faris , Rabail Khowaja , Saad Abdullah

Feature selection has drawn much attention over the last decades in machine learning because it can reduce data dimensionality while maintaining the original physical meaning of features, which enables better interpretability than feature…

Machine Learning · Computer Science 2022-09-27 Yiwen Liao , Jochen Rivoir , Raphaël Latty , Bin Yang

INTRODUCTION: Alzheimer's disease (AD) is genetically complex, complicating robust classification from genomic data. METHODS: We developed a transformer-based ensemble model (TrUE-Net) using Monte Carlo Dropout for uncertainty estimation in…

Genomics · Quantitative Biology 2025-06-03 Taeho Jo , Eun Hye Lee , Alzheimer's Disease Sequencing Project

This paper provides two general classes of multiple decision functions where each member of the first class strongly controls the family-wise error rate (FWER), while each member of the second class strongly controls the false discovery…

Statistics Theory · Mathematics 2019-11-19 Edsel A. Pena , Joshua D. Habiger , Wensong Wu

Obtaining high-quality labels for large datasets is expensive, requiring massive annotations from human experts. While AI models offer a cost-effective alternative by predicting labels, their label quality is compromised by the unavoidable…

Machine Learning · Computer Science 2026-02-17 Huipeng Huang , Wenbo Liao , Huajun Xi , Hao Zeng , Mengchen Zhao , Hongxin Wei

Heart Disease has become one of the most serious diseases that has a significant impact on human life. It has emerged as one of the leading causes of mortality among the people across the globe during the last decade. In order to prevent…

Machine Learning · Computer Science 2022-06-08 Muhammad Salman Pathan , Avishek Nag , Muhammad Mohisn Pathan , Soumyabrata Dev

In this paper, we consider the Click-Through-Rate (CTR) prediction problem. Factorization Machines and their variants consider pair-wise feature interactions, but normally we won't do high-order feature interactions using FM due to high…

Artificial Intelligence · Computer Science 2021-11-30 Kai Wang , Chunxu Shen , Chaoyun Zhang Wenye Ma

Precision medicine seeks to discover an optimal personalized treatment plan and thereby provide informed and principled decision support, based on the characteristics of individual patients. With recent advancements in medical imaging, it…

Methodology · Statistics 2023-04-26 Xinyi Li , Michael R. Kosorok

Feature selection has remained a daunting challenge in machine learning and artificial intelligence, where increasingly complex, high-dimensional datasets demand principled strategies for isolating the most informative predictors. Despite…

Machine Learning · Statistics 2025-12-02 Mousam Sinha , Tirtha Sarathi Ghosh , Ridam Pal

Sorted L-One Penalized Estimation (SLOPE) has shown the nice theoretical property as well as empirical behavior recently on the false discovery rate (FDR) control of high-dimensional feature selection by adaptively imposing the…

Statistics Theory · Mathematics 2023-02-22 Jingxuan Liang , Hong Chen , Xuelin Zhang , Weifu Li , Xin Tang

This paper is a review of the popular Benjamini Hochberg Method and other related useful methods of Multiple Hypothesis testing. This is written with the purpose of serving a short but complete easy to understand review of the main article…

Methodology · Statistics 2014-06-30 Anish Acharya

In this Letter, we introduce a modified collaborative filtering (MCF) algorithm, which has remarkably higher accuracy than the standard collaborative filtering. In the MCF, instead of the standard Pearson coefficient, the user-user…

Data Analysis, Statistics and Probability · Physics 2015-05-13 Jian-Guo Liu , Tao Zhou , Bing-Hong Wang , Yi-Cheng Zhang

Alzheimer's dementia (AD) is of increasing concern as populations achieve longer lifespans. Many of the recent failed AD clinical trials recruiting cognitively intact individuals had a low number of AD events and were thus underpowered.…

Methodology · Statistics 2025-03-21 Julia Gallini , Zach Baucom , Yorghos Tripodis

Feature selection is a critical task in machine learning and statistics. However, existing feature selection methods either (i) rely on parametric methods such as linear or generalized linear models, (ii) lack theoretical false discovery…

Machine Learning · Statistics 2025-07-18 Omar Melikechi , David B. Dunson , Jeffrey W. Miller

In statistics and machine learning, feature selection is the process of picking a subset of relevant attributes for utilizing in a predictive model. Recently, rough set-based feature selection techniques, that employ feature dependency to…

Machine Learning · Computer Science 2020-03-30 Seyedeh Faezeh Farahbakhshian , Milad Taleby Ahvanooey

In large scale multiple testing problems, a two-class empirical Bayes approach can be used to control the false discovery rate (Fdr) for the entire array of hypotheses under study. A sample splitting step is incorporated to modify that…

Computation · Statistics 2019-12-13 Paramita Chakraborty , Chong Ma , John Grego , James Lynch

Factorization Machines (FMs) are a supervised learning approach that enhances the linear regression model by incorporating the second-order feature interactions. Despite effectiveness, FM can be hindered by its modelling of all feature…

Machine Learning · Computer Science 2017-08-17 Jun Xiao , Hao Ye , Xiangnan He , Hanwang Zhang , Fei Wu , Tat-Seng Chua

In this paper, we focus on exploiting the group structure for large-dimensional factor models, which captures the homogeneous effects of common factors on individuals within the same group. In view of the fact that datasets in…

Methodology · Statistics 2024-05-14 Yong He , Xiaoyang Ma , Xingheng Wang , Yalin Wang

The generalized linear models (GLM) have been widely used in practice to model non-Gaussian response variables. When the number of explanatory features is relatively large, scientific researchers are of interest to perform controlled…

Methodology · Statistics 2020-07-03 Chenguang Dai , Buyu Lin , Xin Xing , Jun S. Liu
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