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In this paper, we introduce a novel Multi-Modal Contrastive Pre-training Framework that synergistically combines X-rays, electrocardiograms (ECGs), and radiology/cardiology reports. Our approach leverages transformers to encode these…

Artificial Intelligence · Computer Science 2024-10-24 Samrajya Thapa , Koushik Howlader , Subhankar Bhattacharjee , Wei le

Predicting the motion of surrounding vehicles is essential for autonomous vehicles, as it governs their own motion plan. Current state-of-the-art vehicle prediction models heavily rely on map information. In reality, however, this…

Computer Vision and Pattern Recognition · Computer Science 2022-02-11 Julian Schmidt , Julian Jordan , Franz Gritschneder , Klaus Dietmayer

The scarcity of high-quality multimodal biomedical data limits the ability to effectively fine-tune pretrained Large Language Models (LLMs) for specialized biomedical tasks. To address this challenge, we introduce MINT (Multimodal…

Quantitative Methods · Quantitative Biology 2026-02-18 Zhanliang Wang , Da Wu , Quan Nguyen , Zhuoran Xu , Kai Wang

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Biomolecules · Quantitative Biology 2020-12-17 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

Recent advances in Artificial Intelligence have enabled multi-modal systems to model and translate diverse information spaces. Extending beyond text and vision, we introduce OneProt, a multi-modal AI for proteins that integrates structural,…

Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting cancer drug responses (CDR),…

Quantitative Methods · Quantitative Biology 2023-11-22 Xiaoqiong Xia , Chaoyu Zhu , Yuqi Shan , Fan Zhong , Lei Liu

Computational elucidation of membrane protein (MP) structures is challenging partially due to lack of sufficient solved structures for homology modeling. Here we describe a high-throughput deep transfer learning method that first predicts…

Biomolecules · Quantitative Biology 2017-08-29 Sheng Wang , Zhen Li , Yizhou Yu , Jinbo Xu

We propose a novel inherently interpretable machine learning method that bases decisions on few relevant examples that we call prototypes. Our method, ProtoAttend, can be integrated into a wide range of neural network architectures…

Machine Learning · Computer Science 2019-09-27 Sercan O. Arik , Tomas Pfister

Cancer is a complex disease characterized by uncontrolled cell growth and proliferation. T cell receptors (TCRs) are essential proteins for the adaptive immune system, and their specific recognition of antigens plays a crucial role in the…

Machine Learning · Computer Science 2023-09-07 Zahra Tayebi , Sarwan Ali , Prakash Chourasia , Taslim Murad , Murray Patterson

Predicting the behaviors of other agents on the road is critical for autonomous driving to ensure safety and efficiency. However, the challenging part is how to represent the social interactions between agents and output different possible…

Robotics · Computer Science 2021-09-15 Zhiyu Huang , Xiaoyu Mo , Chen Lv

Multimodal emotion recognition has attracted much attention recently. Fusing multiple modalities effectively with limited labeled data is a challenging task. Considering the success of pre-trained model and fine-grained nature of emotion…

Computation and Language · Computer Science 2023-03-02 Junyi He , Meimei Wu , Meng Li , Xiaobo Zhu , Feng Ye

Predicting accurate protein-ligand binding affinity is important in drug discovery but remains a challenge even with computationally expensive biophysics-based energy scoring methods and state-of-the-art deep learning approaches. Despite…

Survival prediction plays a crucial role in assisting clinicians with the development of cancer treatment protocols. Recent evidence shows that multimodal data can help in the diagnosis of cancer disease and improve survival prediction.…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Ruiquan Ge , Xiangyang Hu , Rungen Huang , Gangyong Jia , Yaqi Wang , Renshu Gu , Changmiao Wang , Elazab Ahmed , Linyan Wang , Juan Ye , Ye Li

Predicting human interaction is challenging as the on-going activity has to be inferred based on a partially observed video. Essentially, a good algorithm should effectively model the mutual influence between the two interacting subjects.…

Computer Vision and Pattern Recognition · Computer Science 2017-05-29 Yichao Yan , Bingbing Ni , Xiaokang Yang

The binding affinity between the T-cell receptors (TCRs) and antigenic peptides mainly determines immunological recognition. It is not a trivial task that T cells identify the digital sequences of peptide amino acids by simply relying on…

Cell Behavior · Quantitative Biology 2024-02-14 Jin Xu , Junghyo Jo

We present PREMISE (PREdict with Matching ScorEs), a new architecture for the matching-based learning in the multimodal fields for the multimodal review helpfulness (MRHP) task. Distinct to previous fusion-based methods which obtains…

Computation and Language · Computer Science 2025-05-05 Wei Han , Hui Chen , Soujanya Poria

As a necessary process in drug development, finding a drug compound that can selectively bind to a specific protein is highly challenging and costly. Drug-target affinity (DTA), which represents the strength of drug-target interaction…

Biomolecules · Quantitative Biology 2023-12-18 Zhiqin Zhu , Zheng Yao , Guanqiu Qi , Neal Mazur , Baisen Cong

Transformers have gained increasing popularity in a wide range of applications, including Natural Language Processing (NLP), Computer Vision and Speech Recognition, because of their powerful representational capacity. However, harnessing…

Structure based ligand discovery is one of the most successful approaches for augmenting the drug discovery process. Currently, there is a notable shift towards machine learning (ML) methodologies to aid such procedures. Deep learning has…

Machine Learning · Statistics 2018-06-12 Marta M. Stepniewska-Dziubinska , Piotr Zielenkiewicz , Pawel Siedlecki

Referring Audio-Visual Segmentation (Ref-AVS) seeks to localize and segment target objects in video frames based on visual, auditory, and textual referring cues. The task is challenging because the relevance of different modalities varies…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Yuchen He , Jing Zhang