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The structure and dynamics of a typical biological system are complex due to strong and inhomogeneous interactions between its constituents. The investigation of such systems with classical mathematical tools, such as differential equations…

Molecular Networks · Quantitative Biology 2008-02-15 Murat Tuğrul

Dynamic gene-regulatory networks are complex since the number of potential components involved in the system is very large. Estimating dynamic networks is an important task because they compromise valuable information about interactions…

Methodology · Statistics 2012-05-15 Antonino Abbruzzo , Ernst Wit

Genetic regulatory networks are usually modeled by systems of coupled differential equations and by finite state models, better known as logical networks, are also used. In this paper we consider a class of models of regulatory networks…

Dynamical Systems · Mathematics 2015-06-26 Ricardo Lima , Edgardo Ugalde

Deep learning models have proven to be exceptionally useful in performing many machine learning tasks. However, for each new dataset, choosing an effective size and structure of the model can be a time-consuming process of trial and error.…

Machine Learning · Computer Science 2019-08-08 Roozbeh Yousefzadeh , Dianne P O'Leary

Learning-based methods could provide solutions to many of the long-standing challenges in control. However, the neural networks (NNs) commonly used in modern learning approaches present substantial challenges for analyzing the resulting…

Machine Learning · Computer Science 2022-02-03 Michael Everett

In spite of the recent interest and advances in linear controllability of complex networks, controlling nonlinear network dynamics remains to be an outstanding problem. We develop an experimentally feasible control framework for nonlinear…

Molecular Networks · Quantitative Biology 2015-09-24 Le-Zhi Wang , Ri-Qi Su , Zi-Gang Huang , Xiao Wang , Wenxu Wang , Celso Grebogi , Ying-Cheng Lai

A nonlinear cyclic system with delay and the overall negative feedback is considered. The characteristic equation of the linearized system is studied in detail. Sufficient conditions for the oscillation of all solutions and for the…

Classical Analysis and ODEs · Mathematics 2019-11-21 Elena Braverman , Karel Hasik , Anatoli F. Ivanov , Sergei Trofimchuk

Synthetic biology is a recent area of biological engineering, whose aim is to provide cells with novel functionalities. A number of important results regarding the development of control circuits in synthetic biology have been achieved…

Systems and Control · Electrical Eng. & Systems 2024-11-11 Antón Pardo , Sandra Díaz Seoane , Dorin A. Ionescu , Antonis Papachristodoulou , Alejandro F. Villaverde

A simple model of oscillator chain with dynamical traps and additive white noise is considered. Its dynamics was studied numerically. As demonstrated, when the trap effect is pronounced nonequilibrium phase transitions of a new type arise.…

Statistical Mechanics · Physics 2009-11-10 Ihor Lubashevsky , Reinhard Mahnke , Morteza Hajimahmoodzadeh , Albert Katsnelson

Sequences of neural activity arise in many brain areas, including cortex, hippocampus, and central pattern generator circuits that underlie rhythmic behaviors like locomotion. While network architectures supporting sequence generation vary…

Neurons and Cognition · Quantitative Biology 2022-08-16 Caitlyn Parmelee , Juliana Londono Alvarez , Carina Curto , Katherine Morrison

This paper studies sequence modeling for prediction tasks with long range dependencies. We propose a new formulation for state space models (SSMs) based on learning linear dynamical systems with the spectral filtering algorithm (Hazan et…

Machine Learning · Computer Science 2024-07-12 Naman Agarwal , Daniel Suo , Xinyi Chen , Elad Hazan

In this paper, we study connections between the classical model-based approach to nonlinear system theory, where systems are represented by equations, and the nonlinear behavioral approach, where systems are defined as sets of trajectories.…

Optimization and Control · Mathematics 2024-05-30 Antonio Fazzi , Alessandro Chiuso

The use of machine learning models in system identification has increased due to their ability to approximate complex nonlinear dynamics with high accuracy. However, often it is not clear how the performance of trained models scales with…

Optimization and Control · Mathematics 2026-03-26 Marco Roschkowski , Karim Cherifi , Hannes Gernandt

Biological systems, from a cell to the human brain, are inherently complex. A powerful representation of such systems, described by an intricate web of relationships across multiple scales, is provided by complex networks. Recently, several…

Quantitative Methods · Quantitative Biology 2018-02-06 M. De Domenico

The temporal activity of many biological systems, including neural circuits, exhibits fluctuations simultaneously varying over a large range of timescales. The mechanisms leading to this temporal heterogeneity are yet unknown. Here we show…

Disordered Systems and Neural Networks · Physics 2022-08-03 Merav Stern , Nicolae Istrate , Luca Mazzucato

Recurrent neural networks have gained widespread use in modeling sequential data. Learning long-term dependencies using these models remains difficult though, due to exploding or vanishing gradients. In this paper, we draw connections…

Machine Learning · Statistics 2019-02-27 Bo Chang , Minmin Chen , Eldad Haber , Ed H. Chi

The identification of a linear system model from data has wide applications in control theory. The existing work that provides finite sample guarantees for linear system identification typically uses data from a single long system…

Machine Learning · Statistics 2025-05-09 Lei Xin , Baike She , Qi Dou , George Chiu , Shreyas Sundaram

Deep learning (DL) has transformed applications in a variety of domains, including computer vision, natural language processing, and tabular data analysis. The search for improved DL model accuracy has led practitioners to explore…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-10 Kabir Nagrecha

We analyze the asymptotic behavior of sequences of random variables defined by an initial condition, a stationary and ergodic sequence of random matrices, and an induction formula involving multiplication is the so-called max-plus algebra.…

Probability · Mathematics 2008-03-12 Glenn Merlet

Network data sets are often constructed by some kind of thresholding procedure. The resulting networks frequently possess properties such as heavy-tailed degree distributions, clustering, large connected components and short average…

Social and Information Networks · Computer Science 2020-06-02 George T. Cantwell , Yanchen Liu , Benjamin F. Maier , Alice C. Schwarze , Carlos A. Serván , Jordan Snyder , Guillaume St-Onge
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