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The Deep learning (DL) models for diagnosing breast cancer from mammographic images often operate as "black boxes", making it difficult for healthcare professionals to trust and understand their decision-making processes. The study presents…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Maryam Ahmed , Tooba Bibi , Rizwan Ahmed Khan , Sidra Nasir

Artificial intelligence (AI) is currently based largely on black-box machine learning models which lack interpretability. The field of eXplainable AI (XAI) strives to address this major concern, being critical in high-stakes areas such as…

Artificial Intelligence · Computer Science 2024-06-26 Sean Tull , Robin Lorenz , Stephen Clark , Ilyas Khan , Bob Coecke

Medical image segmentation is a critical component of clinical workflows, enabling accurate diagnosis, treatment planning, and disease monitoring. However, despite the superior performance of transformer-based models over convolutional…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Thuraya Alzubaidi , Sana Ammar , Maryam Alsharqi , Islem Rekik , Muzammil Behzad

While explainable AI (XAI) is often heralded as a means to enhance transparency and trustworthiness in closed-loop neurotechnology for psychiatric and neurological conditions, its real-world prevalence remains low. Moreover, empirical…

Computers and Society · Computer Science 2026-03-20 Laura Schopp , Ambra DImperio , Jalal Etesami , Marcello Ienca

Artificial intelligence (AI) has rapidly developed through advancements in computational power and the growth of massive datasets. However, this progress has also heightened challenges in interpreting the "black-box" nature of AI models. To…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Shilin Sun , Wenbin An , Feng Tian , Fang Nan , Qidong Liu , Jun Liu , Nazaraf Shah , Ping Chen

The impressive capabilities of deep learning models are often counterbalanced by their inherent opacity, commonly termed the "black box" problem, which impedes their widespread acceptance in high-trust domains. In response, the intersecting…

Machine Learning · Computer Science 2025-09-16 Mitali Raj

To increase the transparency of modern computer-aided diagnosis (CAD) systems for assessing the malignancy of lung nodules, an interpretable model based on applying the generalized additive models and the concept-based learning is proposed.…

Image and Video Processing · Electrical Eng. & Systems 2024-05-29 Rinat I. Dumaev , Sergei A. Molodyakov , Lev V. Utkin

Early detection of skin cancers like melanoma is crucial to ensure high chances of survival for patients. Clinical application of Deep Learning (DL)-based Decision Support Systems (DSS) for skin cancer screening has the potential to improve…

Computer Vision and Pattern Recognition · Computer Science 2021-03-10 Adriano Lucieri , Andreas Dengel , Sheraz Ahmed

Artificial Intelligence models have demonstrated significant success in diagnosing skin diseases, including cancer, showing the potential to assist clinicians in their analysis. However, the interpretability of model predictions must be…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Max Torop , Masih Eskandar , Nicholas Kurtansky , Jinyang Liu , Jochen Weber , Octavia Camps , Veronica Rotemberg , Jennifer Dy , Kivanc Kose

Interpretability is crucial to enhance trust in machine learning models for medical diagnostics. However, most state-of-the-art image classifiers based on neural networks are not interpretable. As a result, clinicians often resort to known…

Being able to explain the prediction to clinical end-users is a necessity to leverage the power of artificial intelligence (AI) models for clinical decision support. For medical images, a feature attribution map, or heatmap, is the most…

Computer Vision and Pattern Recognition · Computer Science 2023-10-17 Weina Jin , Xiaoxiao Li , Ghassan Hamarneh

The clinical diagnosis of skin lesion involves the analysis of dermoscopic and clinical modalities. Dermoscopic images provide a detailed view of the surface structures whereas clinical images offer a complementary macroscopic information.…

Computer Vision and Pattern Recognition · Computer Science 2023-11-17 Hao Wang , Euijoon Ahn , Lei Bi , Jinman Kim

Modern AI systems frequently rely on opaque black-box models, most notably Deep Neural Networks, whose performance stems from complex architectures with millions of learned parameters. While powerful, their complexity poses a major…

Machine Learning · Computer Science 2026-02-23 David Dembinsky , Adriano Lucieri , Stanislav Frolov , Hiba Najjar , Ko Watanabe , Andreas Dengel

Not only automation of manufacturing processes but also automation of automation procedures itself become increasingly relevant to automation research. In this context, automated capability assessment, mainly leveraged by deep learning…

Artificial Intelligence · Computer Science 2022-01-31 Raoul Schönhof , Artem Werner , Jannes Elstner , Boldizsar Zopcsak , Ramez Awad , Marco Huber

In pre-clinical pathology, there is a paradox between the abundance of raw data (whole slide images from many organs of many individual animals) and the lack of pixel-level slide annotations done by pathologists. Due to time constraints and…

Computer Vision and Pattern Recognition · Computer Science 2023-02-06 Marco Bertolini , Van-Khoa Le , Jake Pencharz , Andreas Poehlmann , Djork-Arné Clevert , Santiago Villalba , Floriane Montanari

This paper claims that machine learning models deployed in high stakes domains such as medicine must be interpretable, shareable, reproducible and accountable. We argue that these principles should form the foundational design criteria for…

Machine Learning · Computer Science 2025-08-25 Ayyüce Begüm Bektaş , Mithat Gönen

Artificial Intelligence (AI) has become essential for analyzing complex data and solving highly-challenging tasks. It is being applied across numerous disciplines beyond computer science, including Food Engineering, where there is a growing…

Concept-based Explainable Artificial Intelligence (XAI) interprets deep learning models using human-understandable visual features (e.g., textures or object parts) by linking internal representations to class predictions, thereby bridging…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Giacomo Astolfi , Matteo Bianchi , Riccardo Campi , Antonio De Santis , Marco Brambilla

Deep learning has become popular because of its potential to achieve high accuracy in prediction tasks. However, accuracy is not always the only goal of statistical modelling, especially for models developed as part of scientific research.…

Machine Learning · Computer Science 2021-10-19 Thomas P Quinn , Sunil Gupta , Svetha Venkatesh , Vuong Le

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu