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Multiple sclerosis is a neurological disorder in which the myelin sheaths of axons are damaged by the immune response. We report here a three-dimensional structural analysis of brain and spinal cord tissues of a mouse model of multiple…

Mental disorders present challenges in diagnosis and treatment due to their complex and heterogeneous nature. Electroencephalogram (EEG) has shown promise as a potential biomarker for these disorders. However, existing methods for analyzing…

Methodology · Statistics 2024-01-30 Xingche Guo , Bin Yang , Ji Meng Loh , Qinxia Wang , Yuanjia Wang

The idea to estimate the statistical interdependence among (interacting) brain regions has motivated numerous researchers to investigate how the resulting connectivity patterns and networks may organize themselves under any conceivable…

Neurons and Cognition · Quantitative Biology 2021-02-03 Matteo Fraschini , Simone Maurizio La Cava , Luca Didaci , Luigi Barberini

Multiple Sclerosis (MS) is a chronic, inflammatory and degenerative neurological disease, which is monitored by a specialist using the Expanded Disability Status Scale (EDSS) and recorded in unstructured text in the form of a neurology…

Computation and Language · Computer Science 2020-10-30 Alister D Costa , Stefan Denkovski , Michal Malyska , Sae Young Moon , Brandon Rufino , Zhen Yang , Taylor Killian , Marzyeh Ghassemi

Functional brain imaging through electroencephalography (EEG) relies upon the analysis and interpretation of high-dimensional, spatially organized time series. We propose to represent time-localized frequency domain characterizations of EEG…

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The progression and severity of MS varies by individual, but it is generally a disabling disease. Although medications have been developed to…

Applications · Statistics 2013-03-06 Joyce C. Ho , Joydeep Ghosh , KP Unnikrishnan

Brain activity following stimulus presentation and during resting state are often the result of highly coordinated responses of large numbers of neurons both locally and globally. Coordinated activity of neurons can give rise to…

Applications · Statistics 2015-07-20 Carolina Euan , Hernando Ombao , Joaquin Ortega

The characterization of heart dynamics with a view to distinguish abnormal from normal behavior is an interesting topic in clinical sciences. Here we present an analysis of the Electro-cardiogram (ECG) signals obtained under controlled…

Tissues and Organs · Quantitative Biology 2018-09-05 Snehal M. Shekatkar , Yamini Kotriwar , K. P. Harikrishnan , G. Ambika

In this paper, the brain functional networks derived from high-resolution synchronous EEG time series during visual task are generated by calculating the phase synchronization among the time series. The hierarchical modular organizations of…

Biological Physics · Physics 2015-05-27 Zhao Zhuo , Shi-Min Cai , Zhong-Qian Fu , Jie Zhang

In this paper, we analyze electroencephalograms (EEG) which are recordings of brain electrical activity. We develop new clustering methods for identifying synchronized brain regions, where the EEGs show similar oscillations or waveforms…

Methodology · Statistics 2020-07-29 Tianbo Chen , Ying Sun , Carolina Euan , Hernando Ombao

Brain connectivity can be estimated through a wide number of analyses applied to electroencephalographic (EEG) data. However, substantial heterogeneity in the implementation of connectivity methods exist. Heterogeneity in conceptualization…

Neurons and Cognition · Quantitative Biology 2021-09-01 Aleksandra Miljevic , Neil W. Bailey , Fidel Vila-Rodriguez , Sally E. Herring , Paul B. Fitzgerald

Music, being a multifaceted stimulus evolving at multiple timescales, modulates brain function in a manifold way that encompasses not only the distinct stages of auditory perception but also higher cognitive processes like memory and…

Neurons and Cognition · Quantitative Biology 2018-02-06 Dimitrios A. Adamos , Nikolaos Laskaris , Sifis Micheloyannis

Parkinsons disease (PD) alters cortical neural dynamics, yet reliable non-invasive electrophysiological biomarkers remain elusive. This study examined whether interpretable EEG features capturing complementary aspects of neural dynamics can…

Neurons and Cognition · Quantitative Biology 2026-04-14 Antonios G. Dougalis

The M/EEG inverse problem is ill-posed. Thus additional hypotheses are needed to constrain the solution space. In this work, we consider that brain activity which generates an M/EEG signal is a connected cortical region. We study the case…

Signal Processing · Electrical Eng. & Systems 2018-12-12 Kostiantyn Maksymenko , Maureen Clerc , Théodore Papadopoulo

Electrophysiological observation plays a major role in epilepsy evaluation. However, human interpretation of brain signals is subjective and prone to misdiagnosis. Automating this process, especially seizure detection relying on scalp-based…

Machine Learning · Computer Science 2018-07-06 David Ahmedt-Aristizabal , Clinton Fookes , Kien Nguyen , Sridha Sridharan

Electromyography (EMG) refers to a biomedical signal indicating neuromuscular activity and muscle morphology. Experts accurately diagnose neuromuscular disorders using this time series. Modern data analysis techniques have recently led to…

Social and Information Networks · Computer Science 2021-08-17 Samaneh Samiei , Nasser Ghadiri , Behnaz Ansari

The underlying dynamics for the electroencephalographic (EEG) recordings from humans but especially epilepsy patients are usually not completely known. However, the ictal activity is claimed to be characterized by synchronous oscillations…

Biological Physics · Physics 2010-08-09 Caglar Tuncay

The study of functional connectivity from magnetoecenphalographic (MEG) data consists in quantifying the statistical dependencies among time series describing the activity of different neural sources from the magnetic field recorded outside…

Numerical Analysis · Mathematics 2020-12-01 Elisabetta Vallarino , Michele Piana , Alberto Sorrentino , Sara Sommariva

Classification of electroencephalogram (EEG) and electrocorticogram (ECoG) signals obtained during motor imagery (MI) has substantial application potential, including for communication assistance and rehabilitation support for patients with…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Shuntaro Suzuki , Shunya Nagashima , Masayuki Hirata , Komei Sugiura

We apply modified diffusion entropy analysis (MDEA) to assess multifractal dimensions of ON time series (ONTS) and complexity synchronization (CS) analysis to infer information transfer among ONs that are part of a network of organ networks…