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We present MatUQ, a benchmark framework for evaluating graph neural networks (GNNs) on out-of-distribution (OOD) materials property prediction with uncertainty quantification (UQ). MatUQ comprises 1,375 OOD prediction tasks constructed from…

Machine Learning · Computer Science 2025-11-18 Liqin Tan , Pin Chen , Menghan Liu , Xiean Wang , Jianhuan Cen , Qingsong Zou

Graph neural networks (GNNs) have exhibited remarkable performance under the assumption that test data comes from the same distribution of training data. However, in real-world scenarios, this assumption may not always be valid.…

Machine Learning · Computer Science 2024-02-15 Kai Guo , Hongzhi Wen , Wei Jin , Yaming Guo , Jiliang Tang , Yi Chang

The accurate prediction of material properties is crucial in a wide range of scientific and engineering disciplines. Machine learning (ML) has advanced the state of the art in this field, enabling scientists to discover novel materials and…

Materials Science · Physics 2024-08-20 Qinyang Li , Nicholas Miklaucic , Jianjun Hu

Data-driven molecular discovery leverages artificial intelligence/machine learning (AI/ML) and generative modeling to filter and design novel molecules. Discovering novel molecules requires accurate out-of-distribution (OOD) predictions,…

Machine Learning (ML) techniques have found applications in estimating chemical kinetic properties. With the accumulated drug molecules identified through "AI4drug discovery", the next imperative lies in AI-driven design for high-throughput…

Machine Learning · Computer Science 2023-12-06 Zihao Wang , Yongqiang Chen , Yang Duan , Weijiang Li , Bo Han , James Cheng , Hanghang Tong

Discovery of high-performance materials and molecules requires identifying extremes with property values that fall outside the known distribution. Therefore, the ability to extrapolate to out-of-distribution (OOD) property values is…

Machine Learning · Computer Science 2025-02-11 Nofit Segal , Aviv Netanyahu , Kevin P. Greenman , Pulkit Agrawal , Rafael Gomez-Bombarelli

Detecting and understanding out-of-distribution (OOD) samples is crucial in machine learning (ML) to ensure reliable model performance. Current OOD studies primarily focus on extrapolatory (outside) OOD, neglecting potential cases of…

Machine Learning · Computer Science 2025-09-03 Teddy Lazebnik

Deep neural networks (DNNs) have become a key part of many modern software applications. After training and validating, the DNN is deployed as an irrevocable component and applied in real-world scenarios. Although most DNNs are built…

Machine Learning · Computer Science 2021-03-31 JingWei Xu , Siyuan Zhu , Zenan Li , Chang Xu

Recently, there has been gradually more attention paid to Out-of-Distribution (OOD) performance prediction, whose goal is to predict the performance of trained models on unlabeled OOD test datasets, so that we could better leverage and…

Machine Learning · Computer Science 2025-11-03 Han Yu , Kehan Li , Dongbai Li , Yue He , Xingxuan Zhang , Peng Cui

Out-of-distribution (OOD) detection is essential for ensuring the reliability of deep learning models operating in open-world scenarios. Current OOD detectors mainly rely on statistical models to identify unusual patterns in the latent…

Machine Learning · Computer Science 2025-06-06 Konstantin Kirchheim , Frank Ortmeier

Deep neural networks are increasingly used in a wide range of technologies and services, but remain highly susceptible to out-of-distribution (OOD) samples, that is, drawn from a different distribution than the original training set. A…

Machine Learning · Computer Science 2024-04-17 Pietro Recalcati , Fabio Garcea , Luca Piano , Fabrizio Lamberti , Lia Morra

Materials property prediction models are usually evaluated using random splitting of datasets into training and test datasets, which not only leads to over-estimated performance due to inherent redundancy, typically existent in material…

Materials Science · Physics 2024-05-28 Jeffrey Hu , David Liu , Nihang Fu , Rongzhi Dong

Graph neural networks (GNNs) have achieved impressive performance when testing and training graph data come from identical distribution. However, existing GNNs lack out-of-distribution generalization abilities so that their performance…

Machine Learning · Computer Science 2021-12-15 Haoyang Li , Xin Wang , Ziwei Zhang , Wenwu Zhu

Detecting and rejecting unknown out-of-distribution (OOD) samples is critical for deployed neural networks to void unreliable predictions. In real-world scenarios, however, the efficacy of existing OOD detection methods is often impeded by…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Kai Liu , Zhihang Fu , Sheng Jin , Chao Chen , Ze Chen , Rongxin Jiang , Fan Zhou , Yaowu Chen , Jieping Ye

Out of distribution (OOD) detection is a crucial part of making machine learning systems robust. The ImageNet-O dataset is an important tool in testing the robustness of ImageNet trained deep neural networks that are widely used across a…

Computer Vision and Pattern Recognition · Computer Science 2022-01-25 Anugya Srivastava , Shriya Jain , Mugdha Thigle

It is crucial to detect when an instance lies downright too far from the training samples for the machine learning model to be trusted, a challenge known as out-of-distribution (OOD) detection. For neural networks, one approach to this task…

This paper presents a novel evaluation framework for Out-of-Distribution (OOD) detection that aims to assess the performance of machine learning models in more realistic settings. We observed that the real-world requirements for testing OOD…

Computer Vision and Pattern Recognition · Computer Science 2023-09-01 Vahid Reza Khazaie , Anthony Wong , Mohammad Sabokrou

When machine learning (ML) models are supplied with data outside their training distribution, they are more likely to make inaccurate predictions; in a cyber-physical system (CPS), this could lead to catastrophic system failure. To mitigate…

Machine Learning · Computer Science 2022-08-01 Michael Yuhas , Daniel Jun Xian Ng , Arvind Easwaran

Machine learning has revolutionized materials property prediction, yet fails catastrophically when extrapolating beyond training distributions-precisely the capability required for discovering unprecedented materials. Graph neural networks…

Materials Science · Physics 2026-02-23 Tasuku Sugiura , Teruyasu Mizoguchi

Out-of-distribution detection is an important capability that has long eluded vanilla neural networks. Deep Neural networks (DNNs) tend to generate over-confident predictions when presented with inputs that are significantly…

Machine Learning · Computer Science 2022-02-24 Sumedh A Sontakke , Buvaneswari Ramanan , Laurent Itti , Thomas Woo
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