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Related papers: Interpretable deep learning in single-cell omics

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The increasing adoption of machine learning tools has led to calls for accountability via model interpretability. But what does it mean for a machine learning model to be interpretable by humans, and how can this be assessed? We focus on…

Machine Learning · Computer Science 2019-08-06 Dylan Slack , Sorelle A. Friedler , Carlos Scheidegger , Chitradeep Dutta Roy

The lack of transparency in the decision-making processes of deep learning systems presents a significant challenge in modern artificial intelligence (AI), as it impairs users' ability to rely on and verify these systems. To address this…

Artificial Intelligence · Computer Science 2024-11-18 David Debot , Pietro Barbiero , Francesco Giannini , Gabriele Ciravegna , Michelangelo Diligenti , Giuseppe Marra

Deep neural networks have achieved remarkable success in computer vision; however, their black-box nature in decision-making limits interpretability and trust, particularly in safety-critical applications. Interpretability is crucial in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Ran Eisenberg , Amit Rozner , Ethan Fetaya , Ofir Lindenbaum

Over the past several years, legal applications of deep learning have been on the rise. However, as with other high-stakes decision making areas, the requirement for interpretability is of crucial importance. Current models utilized by…

Machine Learning · Computer Science 2022-01-05 Rohan Bhambhoria , Hui Liu , Samuel Dahan , Xiaodan Zhu

Single-cell analysis is currently one of the most high-resolution techniques to study biology. The large complex datasets that have been generated have spurred numerous developments in computational biology, in particular the use of…

Genomics · Quantitative Biology 2023-04-27 Ionut Sebastian Mihai , Sarang Chafle , Johan Henriksson

Deep learning methods have become very popular for the processing of natural images, and were then successfully adapted to the neuroimaging field. As these methods are non-transparent, interpretability methods are needed to validate them…

Computer Vision and Pattern Recognition · Computer Science 2022-04-15 Elina Thibeau-Sutre , Sasha Collin , Ninon Burgos , Olivier Colliot

The increasing availability of large collections of electronic health record (EHR) data and unprecedented technical advances in deep learning (DL) have sparked a surge of research interest in developing DL based clinical decision support…

Machine Learning · Computer Science 2021-12-07 Di Jin , Elena Sergeeva , Wei-Hung Weng , Geeticka Chauhan , Peter Szolovits

The lack of explainability is one of the most prominent disadvantages of deep learning applications in omics. This "black box" problem can undermine the credibility and limit the practical implementation of biomedical deep learning models.…

Genomics · Quantitative Biology 2021-08-19 Eloise Withnell , Xiaoyu Zhang , Kai Sun , Yike Guo

The landscape in the context of several signal processing applications and even education appears to be significantly affected by the emergence of machine learning (ML) and in particular deep learning (DL).The main reason for this is the…

Signal Processing · Electrical Eng. & Systems 2023-02-07 Manish Narwaria

Interpretable representations are the backbone of many explainers that target black-box predictive systems based on artificial intelligence and machine learning algorithms. They translate the low-level data representation necessary for good…

Machine Learning · Computer Science 2024-04-29 Kacper Sokol , Peter Flach

The ability to interpret machine learning models has become increasingly important now that machine learning is used to inform consequential decisions. We propose an approach called model extraction for interpreting complex, blackbox…

Machine Learning · Computer Science 2018-03-14 Osbert Bastani , Carolyn Kim , Hamsa Bastani

Deep learning methods are highly accurate, yet their opaque decision process prevents them from earning full human trust. Concept-based models aim to address this issue by learning tasks based on a set of human-understandable concepts.…

We present a brief history of the field of interpretable machine learning (IML), give an overview of state-of-the-art interpretation methods, and discuss challenges. Research in IML has boomed in recent years. As young as the field is, it…

Machine Learning · Statistics 2022-01-24 Christoph Molnar , Giuseppe Casalicchio , Bernd Bischl

The black box nature of deep neural networks poses a significant challenge for the deployment of transparent and trustworthy artificial intelligence (AI) systems. With the growing presence of AI in society, it becomes increasingly important…

Machine Learning · Computer Science 2025-11-25 Bianka Kowalska , Halina Kwaśnicka

Data-driven models are central to scientific discovery. In efforts to achieve state-of-the-art model accuracy, researchers are employing increasingly complex machine learning algorithms that often outperform simple regressions in…

Materials Science · Physics 2022-12-21 Eric S. Muckley , James E. Saal , Bryce Meredig , Christopher S. Roper , John H. Martin

Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…

Machine Learning · Computer Science 2023-07-20 Md. Mahfuzur Rahman , Vince D. Calhoun , Sergey M. Plis

Machine learning models have had discernible achievements in a myriad of applications. However, most of these models are black-boxes, and it is obscure how the decisions are made by them. This makes the models unreliable and untrustworthy.…

Machine Learning · Computer Science 2020-03-23 Raha Moraffah , Mansooreh Karami , Ruocheng Guo , Adrienne Raglin , Huan Liu

The interpretability of ML models is important, but it is not clear what it amounts to. So far, most philosophers have discussed the lack of interpretability of black-box models such as neural networks, and methods such as explainable AI…

Machine Learning · Computer Science 2024-01-05 Tim Räz

The impressive capabilities of deep learning models are often counterbalanced by their inherent opacity, commonly termed the "black box" problem, which impedes their widespread acceptance in high-trust domains. In response, the intersecting…

Machine Learning · Computer Science 2025-09-16 Mitali Raj

The objective of this proposal is to bridge the gap between Deep Learning (DL) and System Dynamics (SD) by developing an interpretable neural system dynamics framework. While DL excels at learning complex models and making accurate…

Machine Learning · Computer Science 2025-05-21 Riccardo D'Elia