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Related papers: Two Directions for Clinical Data Generation with L…

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Real-world domain experts (e.g., doctors) rarely annotate only a decision label in their day-to-day workflow without providing explanations. Yet, existing low-resource learning techniques, such as Active Learning (AL), that aim to support…

Computation and Language · Computer Science 2023-10-24 Bingsheng Yao , Ishan Jindal , Lucian Popa , Yannis Katsis , Sayan Ghosh , Lihong He , Yuxuan Lu , Shashank Srivastava , Yunyao Li , James Hendler , Dakuo Wang

Objective Alzheimer disease (AD) is the most common cause of dementia, a syndrome characterized by cognitive impairment severe enough to interfere with activities of daily life. We aimed to conduct a systematic literature review (SLR) of…

Quantitative Methods · Quantitative Biology 2021-08-31 Sayantan Kumar , Inez Oh , Suzanne Schindler , Albert M Lai , Philip R O Payne , Aditi Gupta

This paper investigates the automation of qualitative data analysis, focusing on inductive coding using large language models (LLMs). Unlike traditional approaches that rely on deductive methods with predefined labels, this research…

Computation and Language · Computer Science 2025-12-02 Angelina Parfenova , Andreas Marfurt , Alexander Denzler , Juergen Pfeffer

Research related to automatically detecting Alzheimer's disease (AD) is important, given the high prevalence of AD and the high cost of traditional methods. Since AD significantly affects the content and acoustics of spontaneous speech,…

Computation and Language · Computer Science 2020-08-05 Aparna Balagopalan , Benjamin Eyre , Frank Rudzicz , Jekaterina Novikova

Disease progression prediction based on patients' evolving health information is challenging when true disease states are unknown due to diagnostic capabilities or high costs. For example, the absence of gold-standard neurological diagnoses…

Methodology · Statistics 2024-12-12 Zexi Cai , Donglin Zeng , Karen S. Marder , Lawrence S. Honig , Yuanjia Wang

Alzheimer's Disease (AD) is a significant and growing public health concern. Investigating alterations in speech and language patterns offers a promising path towards cost-effective and non-invasive early detection of AD on a large scale.…

Computation and Language · Computer Science 2024-12-23 Jonathan Heitz , Gerold Schneider , Nicolas Langer

Existing anomaly detection (AD) methods for tabular data usually rely on some assumptions about anomaly patterns, leading to inconsistent performance in real-world scenarios. While Large Language Models (LLMs) show remarkable reasoning…

Machine Learning · Computer Science 2026-03-31 Hangting Ye , Jinmeng Li , He Zhao , Mingchen Zhuge , Dandan Guo , Yi Chang , Hongyuan Zha

United States healthcare systems are struggling to meet the growing demand for neurological care, particularly in Alzheimer's disease and related dementias (ADRD). Generative AI built on language models (LLMs) now enables agentic AI systems…

Large language models (LLMs) have revolutionised many fields, with LLM-as-a-service (LLMSaaS) offering accessible, general-purpose solutions without costly task-specific training. In contrast to the widely studied prompt engineering for…

Computation and Language · Computer Science 2026-03-17 Md Rakibul Hasan , Yue Yao , Md Zakir Hossain , Aneesh Krishna , Imre Rudas , Shafin Rahman , Tom Gedeon

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

Artificial Intelligence · Computer Science 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

Large, publicly available clinical datasets have emerged as a novel resource for understanding disease heterogeneity and to explore personalization of therapy. These datasets are derived from data not originally collected for research…

Machine Learning · Computer Science 2025-08-14 Anish Narain , Ritam Majumdar , Nikita Narayanan , Dominic Marshall , Sonali Parbhoo

Access to real-world medical data is often restricted due to privacy regulations, posing a significant barrier to the advancement of healthcare research. Synthetic data offers a promising alternative; however, generating realistic,…

Artificial Intelligence · Computer Science 2025-08-13 Arshia Ilaty , Hossein Shirazi , Hajar Homayouni

As the global burden of Alzheimer's disease (AD) continues to grow, early and accurate detection has become increasingly critical, especially in regions with limited access to advanced diagnostic tools. We propose BRAINS (Biomedical…

Machine Learning · Computer Science 2025-11-05 Rajan Das Gupta , Md Kishor Morol , Nafiz Fahad , Md Tanzib Hosain , Sumaya Binte Zilani Choya , Md Jakir Hossen

Patients with diabetes are at increased risk of comorbid depression or anxiety, complicating their management. This study evaluated the performance of large language models (LLMs) in detecting these symptoms from secure patient messages. We…

Congenital heart disease (CHD) presents complex, lifelong challenges often underrepresented in traditional clinical metrics. While unstructured narratives offer rich insights into patient and caregiver experiences, manual thematic analysis…

Computation and Language · Computer Science 2025-08-12 Seungjun Yi , Joakim Nguyen , Huimin Xu , Terence Lim , Andrew Well , Mia Markey , Ying Ding

Identifying disease interconnections through manual analysis of large-scale clinical data is labor-intensive, subjective, and prone to expert disagreement. While machine learning (ML) shows promise, three critical challenges remain: (1)…

Objective: this study has a twofold goal. First, it aims to improve the understanding of the impact of Dementia of type Alzheimer's Disease (AD) on different aspects of the lexicon. Second, it aims to demonstrate that such aspects of the…

Computation and Language · Computer Science 2023-07-18 M. Zakaria Kurdi

The utilization of Electronic Health Records (EHRs) for clinical risk prediction is on the rise. However, strict privacy regulations limit access to comprehensive health records, making it challenging to apply standard machine learning…

Computation and Language · Computer Science 2023-12-08 Angeela Acharya , Sulabh Shrestha , Anyi Chen , Joseph Conte , Sanja Avramovic , Siddhartha Sikdar , Antonios Anastasopoulos , Sanmay Das

Large language models (LLMs) show promise for health applications when combined with behavioral sensing data. Traditional approaches convert sensor data into text prompts, but this process is prone to errors, computationally expensive, and…

Foundation large language models (LLMs) have shown an impressive ability to solve tasks across a wide range of fields including health. To effectively solve personalized health tasks, LLMs need the ability to ingest a diversity of data…

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