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Sepsis is a life-threatening condition that requires rapid detection and treatment to prevent progression to severe sepsis, septic shock, or multi-organ failure. Despite advances in medical technology, it remains a major challenge for…

Machine Learning · Computer Science 2025-11-11 Atharva Thakur , Shruti Dhumal

Drug-resistant epilepsy is traditionally characterized by pathologic cortical tissue comprised of seizure-initiating `foci'. These `foci' are thought to be embedded within an epileptic network whose functional architecture dynamically…

Neurons and Cognition · Quantitative Biology 2016-02-17 Ankit Khambhati , Brian Litt , Danielle S. Bassett

Background: Small interfering RNA (siRNA) is a promising therapeutic agent due to its ability to silence disease-related genes via RNA interference. While traditional machine learning and early deep learning methods have made progress in…

Biomolecules · Quantitative Biology 2025-03-07 Wangdan Liao , Weidong Wang

Re-entry of travelling excitation loops is a long-suspected driver of human seizures, yet how such loops arise in patient brain networks -- and how susceptible they are to targeted disruption -- remains unclear. We reconstruct a…

Neurons and Cognition · Quantitative Biology 2025-08-08 Paul Triebkorn , Huifang E. Wang , Marmaduke Woodman , Maxime Guye , Fabrice Bartolomei , Viktor Jirsa

In this study, we developed and tested machine learning models to predict epilepsy surgical outcome using noninvasive clinical and demographic data from patients. Methods: Seven dif-ferent categorization algorithms were used to analyze the…

An epileptic seizure is a transient event of abnormal excessive neuronal discharge in the brain. This unwanted event can be obstructed by detection of electrical changes in the brain that happen before the seizure takes place. The automatic…

Machine Learning · Computer Science 2016-04-29 Z. Roshan Zamir

Epilepsy is a common neurological disorder characterized by recurrent seizures accompanied by excessive synchronous brain activity. The process of structural and functional brain alterations leading to increased seizure susceptibility and…

Signal Processing · Electrical Eng. & Systems 2020-06-18 Diyuan Lu , Sebastian Bauer , Valentin Neubert , Lara Sophie Costard , Felix Rosenow , Jochen Triesch

The electrical stimulation to the seizure onset zone (SOZ) serves as an efficient approach to seizure suppression. Recently, seizure dynamics have gained widespread attendance in its network propagation mechanisms. Compared with the direct…

Neurons and Cognition · Quantitative Biology 2024-06-17 Zhichao Liang , Guanyi Zhao , Yinuo Zhang , Weiting Sun , Jingzhe Lin , Jialin Wang , Quanying Liu

Electroencephalography (EEG) is essential for the diagnosis of epilepsy, but it requires expertise and experience to identify abnormalities. It is thus crucial to develop automated models for the detection of abnormalities in EEGs related…

Signal Processing · Electrical Eng. & Systems 2021-11-23 Taku Shoji , Noboru Yoshida , Toshihisa Tanaka

Detailed analysis of seizure semiology, the symptoms and signs which occur during a seizure, is critical for management of epilepsy patients. Inter-rater reliability using qualitative visual analysis is often poor for semiological features.…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Fernando Pérez-García , Catherine Scott , Rachel Sparks , Beate Diehl , Sébastien Ourselin

Epilepsy significantly impacts global health, affecting about 65 million people worldwide, along with various animal species. The diagnostic processes of epilepsy are often hindered by the transient and unpredictable nature of seizures.…

Signal Processing · Electrical Eng. & Systems 2026-04-21 Z. Wang , S. Li , Dongrui Wu

In this study, we present a criterion based on the analysis of EEG signals through the mean of the conventional power spectral density (PSD) in the aim to localize and detect the epileptic area of the brain. Firstly, as the EEG signals are…

Applications · Statistics 2016-10-31 Mahamat Ali Issaka , Ali S. Dabye , Lamine Gueye

The two-point central difference is a common algorithm in biological signal processing and is particularly useful in analyzing physiological signals. In this paper, we develop a model-based classification method to detect epileptic seizures…

Applications · Statistics 2020-06-01 Antonio Quintero-Rincon , Carlos D'Giano , Hadj Batatia

Objective: Forecasting epileptic seizures can reduce uncertainty for patients and allow preventative actions. While many models can predict the occurrence of seizures from features of the EEG, few models incorporate changes in features over…

Neurons and Cognition · Quantitative Biology 2023-09-19 Daniel E. Payne , Jordan D. Chambers , Anthony Burkitt , Mark J. Cook , Levin Kuhlman , Dean R. Freestone , David B. Grayden

Machine learning methods, such as deep learning, show promising results in the medical domain. However, the lack of interpretability of these algorithms may hinder their applicability to medical decision support systems. This paper studies…

Signal Processing · Electrical Eng. & Systems 2021-07-23 Juan Manuel Mayor-Torres , Mirco Ravanelli , Sara E. Medina-DeVilliers , Matthew D. Lerner , Giuseppe Riccardi

Epilepsy is one of the common neurological disorders characterized by recurrent and uncontrollable seizures, which seriously affect the life of patients. In many cases, electroencephalograms signal can provide important physiological…

Neurons and Cognition · Quantitative Biology 2023-08-15 Mohammad Reza Yousefi , Saina Golnejad , Melika Mohammad Hosseini , Amin Dehghani

Epilepsy is a common neurological disorder characterized by abrupt seizures. Although seizures may appear random, they are often preceded by early warning signs in neural signals, notably, critical slowing down, a phenomenon in which the…

Systems and Control · Electrical Eng. & Systems 2024-11-12 Yuzhen Qin , Marcel van Gerven

Sepsis is a deadly condition affecting many patients in the hospital. Recent studies have shown that patients diagnosed with sepsis have significant mortality and morbidity, resulting from the body's dysfunctional host response to…

Machine Learning · Computer Science 2022-12-14 Ronald Moore , Rishikesan Kamaleswaran

Epilepsy is a neurological illness that is characterised by continuous spasms of shaking, sometimes known as convulsions. Although there are effective treatments for epilepsy, such as drugs and surgery, there is still a group of individuals…

Artificial Intelligence · Computer Science 2023-05-01 Ishan Shivansh Bangroo , Samia Tahzeen

Epileptic seizures are transient neurological events characterized by abnormal and excessive neuron activity in the brain, which are often associated with measurable disturbances in the cardiovascular system. Traditionally,…

Signal Processing · Electrical Eng. & Systems 2026-05-20 Mohammad Reza Chopannavaz , Foad Ghaderi
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