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The use of causal mediation analysis to evaluate the pathways by which an exposure affects an outcome is widespread in the social and biomedical sciences. Recent advances in this area have established formal conditions for identification…

Methodology · Statistics 2018-08-14 Isabel R. Fulcher , Xu Shi , Eric J. Tchetgen Tchetgen

Many economic studies use shift-share instruments to estimate causal effects. Often, all shares need to fulfil an exclusion restriction, making the identifying assumption strict. This paper proposes to use methods that relax the exclusion…

Econometrics · Economics 2022-07-05 Nicolas Apfel

If an experimental treatment is experienced by both treated and control group units, tests of hypotheses about causal effects may be difficult to conceptualize let alone execute. In this paper, we show how counterfactual causal models may…

Methodology · Statistics 2012-08-03 Jake Bowers , Mark Fredrickson , Costas Panagopoulos

There is a large literature on semiparametric estimation of average treatment effects under unconfounded treatment assignment in settings with a fixed number of covariates. More recently attention has focused on settings with a large number…

Methodology · Statistics 2017-10-26 Susan Athey , Guido Imbens , Thai Pham , Stefan Wager

Causal inference with interference is a rapidly growing area. The literature has begun to relax the "no-interference" assumption that the treatment received by one individual does not affect the outcomes of other individuals. In this paper…

Methodology · Statistics 2015-03-06 Tyler J. VanderWeele , Eric J. Tchetgen Tchetgen , M. Elizabeth Halloran

When teaching and discussing statistical assumptions, our focus is oftentimes placed on how to test and address potential violations rather than the effects of violating assumptions on the estimates produced by our statistical models. The…

Methodology · Statistics 2022-06-14 Ian A Silver

We propose a method for estimation and inference for bounds for heterogeneous causal effect parameters in general sample selection models where the treatment can affect whether an outcome is observed and no exclusion restrictions are…

Econometrics · Economics 2024-07-29 Phillip Heiler

Citations are commonly held to represent scientific impact. To date, however, there is no empirical evidence in support of this postulate that is central to research assessment exercises and Science of Science studies. Here, we report on…

Digital Libraries · Computer Science 2016-12-14 Filippo Radicchi , Alexander Weissman , Johan Bollen

Missing exposure information is a very common feature of many observational studies. Here we study identifiability and efficient estimation of causal effects on vector outcomes, in such cases where treatment is unconfounded but partially…

Methodology · Statistics 2020-02-04 Edward H. Kennedy

Although living organisms are affected by many interrelated and unidentified variables, this complexity does not automatically impose a fundamental limitation on statistical inference. Nor need one invoke such complexity as an explanation…

Data Analysis, Statistics and Probability · Physics 2013-02-06 Drew M. Thomas

Causal mediation analysis provides techniques for defining and estimating effects that may be endowed with mechanistic interpretations. With many scientific investigations seeking to address mechanistic questions, causal direct and indirect…

Controversy about the significance of underdetermination of theories persists in the philosophy and conduct of science. The issue has practical import when research is used to inform decision making, because scientific uncertainty yields…

Econometrics · Economics 2026-04-09 Charles F. Manski

This perspective posits that gene-environment interplay (GxE) studies should be developed both theoretically and empirically to be of relevance to policy makers. On the theoretical front, this development is essential because the current…

Other Quantitative Biology · Quantitative Biology 2025-07-17 Dilnoza Muslimova , Niels Rietveld

Observational studies are often used to understand relationships between exposures and outcomes. They do not, however, allow conclusions about causal relationships to be drawn unless statistical techniques are used to account for the…

The paper presents some models for the propensity score. Considerable attention is given to a recently popular, but relatively under-explored setting in causal inference where the no-interference assumption does not hold. We lay out some…

Methodology · Statistics 2022-08-16 Hyunseung Kang , Chan Park , Ralph Trane

Causal inference for air pollution mixtures is an increasingly important issue with appreciable challenges. When the exposure is a multivariate mixture, there are many exposure contrasts that may be of nominal interest for causal effect…

Methodology · Statistics 2024-02-01 Joseph Antonelli , Corwin Zigler

This paper discusses the fundamental principles of causal inference - the area of statistics that estimates the effect of specific occurrences, treatments, interventions, and exposures on a given outcome from experimental and observational…

Methodology · Statistics 2021-12-03 Francesca Dominici , Falco J. Bargagli-Stoffi , Fabrizia Mealli

This paper is concerned with the selection and estimation of fixed and random effects in linear mixed effects models. We propose a class of nonconcave penalized profile likelihood methods for selecting and estimating important fixed…

Statistics Theory · Mathematics 2012-11-05 Yingying Fan , Runze Li

We consider continuous-time survival or more general event-history settings, where the aim is to infer the causal effect of a time-dependent treatment process. This is formalised as the effect on the outcome event of a (possibly…

Methodology · Statistics 2024-04-23 Kjetil Røysland , Pål Ryalen , Mari Nygård , Vanessa Didelez

Typically, a randomized experiment is designed to test a hypothesis about the average treatment effect and sometimes hypotheses about treatment effect variation. The results of such a study may then be used to inform policy and practice for…

Methodology · Statistics 2026-05-01 Elizabeth Tipton , Michalis Mamakos
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