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Recent advances in microscopy have enabled the rapid generation of terabytes of image data in cell biology and biomedical research. Vision-language models (VLMs) offer a promising solution for large-scale biological image analysis,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Alejandro Lozano , Jeffrey Nirschl , James Burgess , Sanket Rajan Gupte , Yuhui Zhang , Alyssa Unell , Serena Yeung-Levy

Hallucination remains a central failure mode of large language models, but existing benchmarks operationalize it inconsistently across summarization, question answering, retrieval-augmented generation, and agentic interaction. This…

Computation and Language · Computer Science 2026-05-20 Emmy Liu , Varun Gangal , Michael Yu , Zhuofu Tao , Karan Singh , Sachin Kumar , Steven Y. Feng

Hallucinations in large vision-language models (LVLMs) pose significant challenges for real-world applications, as LVLMs may generate responses that appear plausible yet remain inconsistent with the associated visual content. This issue…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Xin Dong , Shichao Dong , Jin Wang , Jing Huang , Li Zhou , Zenghui Sun , Lihua Jing , Jingsong Lan , Xiaoyong Zhu , Bo Zheng

Document Visual Question Answering (VQA) models have evolved at an impressive rate over the past few years, coming close to or matching human performance on some benchmarks. We argue that common evaluation metrics used by popular benchmarks…

Computation and Language · Computer Science 2025-03-26 Armineh Nourbakhsh , Siddharth Parekh , Pranav Shetty , Zhao Jin , Sameena Shah , Carolyn Rose

Large language models (LLMs) have recently experienced remarkable progress, where the advent of multi-modal large language models (MLLMs) has endowed LLMs with visual capabilities, leading to impressive performances in various multi-modal…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Tianyang Han , Qing Lian , Rui Pan , Renjie Pi , Jipeng Zhang , Shizhe Diao , Yong Lin , Tong Zhang

Large Vision-Language Models (LVLMs) have become essential for advancing the integration of visual and linguistic information. However, the evaluation of LVLMs presents significant challenges as the evaluation benchmark always demands lots…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Han Bao , Yue Huang , Yanbo Wang , Jiayi Ye , Xiangqi Wang , Xiuying Chen , Yue Zhao , Tianyi Zhou , Mohamed Elhoseiny , Xiangliang Zhang

Large Language Models (LLMs) have gained widespread adoption in various natural language processing tasks, including question answering and dialogue systems. However, a major drawback of LLMs is the issue of hallucination, where they…

Computation and Language · Computer Science 2024-07-08 Yuyan Chen , Qiang Fu , Yichen Yuan , Zhihao Wen , Ge Fan , Dayiheng Liu , Dongmei Zhang , Zhixu Li , Yanghua Xiao

Large Language Models (LLMs) have succeeded in a variety of natural language processing tasks [Zha+25]. However, they have notable limitations. LLMs tend to generate hallucinations, a seemingly plausible yet factually unsupported output…

Computation and Language · Computer Science 2025-09-19 Martin Preiß

Establishing a clear link between model predictions and the visual evidence that supports them is critical for transparency and reliability in multimodal reasoning, yet current multimodal large language model (MLLM) evaluations do not…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Mozhgan Nasr Azadani , Yimu Wang , Yongpeng Zhu , Lihong Chen , Milan Ganai , Sean Sedwards , Marco Pavone , Krzysztof Czarnecki

Several recent works seek to adapt general-purpose large language models (LLMs) and vision-language models (VLMs) for medical applications through continued pretraining on publicly available biomedical corpora. These works typically claim…

Computation and Language · Computer Science 2025-07-01 Daniel P. Jeong , Pranav Mani , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Multimodal Large Language Models (MLLMs) have shown impressive performance in vision and text tasks. However, hallucination remains a major challenge, especially in fields like healthcare where details are critical. In this work, we show…

Computation and Language · Computer Science 2025-02-24 Yun-Wei Chu , Kai Zhang , Christopher Malon , Martin Renqiang Min

Visual Question Answering (VQA) in the medical domain presents a unique, interdisciplinary challenge, combining fields such as Computer Vision, Natural Language Processing, and Knowledge Representation. Despite its importance, research in…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Abhishek Narayanan , Rushabh Musthyala , Rahul Sankar , Anirudh Prasad Nistala , Pranav Singh , Jacopo Cirrone

Large language models (LLMs) are increasingly deployed in multilingual applications but often generate plausible yet incorrect or misleading outputs, known as hallucinations. While hallucination detection has been studied extensively in…

Computation and Language · Computer Science 2025-12-02 Hrishikesh Terdalkar , Kirtan Bhojani , Aryan Dongare , Omm Aditya Behera

In recent years, visual question answering (VQA) has become topical. The premise of VQA's significance as a benchmark in AI, is that both the image and textual question need to be well understood and mutually grounded in order to infer the…

Computer Vision and Pattern Recognition · Computer Science 2018-03-20 Feng Liu , Tao Xiang , Timothy M. Hospedales , Wankou Yang , Changyin Sun

Visual hallucinations in Large Language Models (LLMs), where the model generates responses that are inconsistent with the visual input, pose a significant challenge to their reliability, particularly in contexts where precise and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Nokimul Hasan Arif , Shadman Rabby , Md Hefzul Hossain Papon , Sabbir Ahmed

Large language models have proliferated across multiple domains in as short period of time. There is however hesitation in the medical and healthcare domain towards their adoption because of issues like factuality, coherence, and…

Computation and Language · Computer Science 2023-11-06 Muhammad Aurangzeb Ahmad , Ilker Yaramis , Taposh Dutta Roy

Multimodal Large Language Models (MLLMs) have demonstrated strong performance in visual understanding tasks, yet they often suffer from object hallucinations--generating descriptions of objects that are inconsistent with or entirely absent…

Artificial Intelligence · Computer Science 2025-05-27 Xinmiao Hu , Chun Wang , Ruihe An , ChenYu Shao , Xiaojun Ye , Sheng Zhou , Liangcheng Li

Uncertainty quantification (UQ) is vital for ensuring that vision-language models (VLMs) behave safely and reliably. A central challenge is to localize uncertainty to its source, determining whether it arises from the image, the text, or…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Chenyu Wang , Tianle Chen , H. M. Sabbir Ahmad , Kayhan Batmanghelich , Wenchao Li

Recent advancements in multimodal large language models (MLLMs) have shown unprecedented capabilities in advancing various vision-language tasks. However, MLLMs face significant challenges with hallucinations, and misleading outputs that do…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Shengqiong Wu , Hao Fei , Liangming Pan , William Yang Wang , Shuicheng Yan , Tat-Seng Chua

Large language models (LLMs) have achieved a degree of success in generating coherent and contextually relevant text, yet they remain prone to a significant challenge known as hallucination: producing information that is not substantiated…

Computation and Language · Computer Science 2024-10-28 Ray Li , Tanishka Bagade , Kevin Martinez , Flora Yasmin , Grant Ayala , Michael Lam , Kevin Zhu