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Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Analyzing vast textual data and summarizing key information from electronic health records imposes a substantial burden on how clinicians allocate their time. Although large language models (LLMs) have shown promise in natural language…

Reinforcement learning from human feedback (RLHF) has emerged as a reliable approach to aligning large language models (LLMs) to human preferences. Among the plethora of RLHF techniques, proximal policy optimization (PPO) is of the most…

Computation and Language · Computer Science 2023-11-06 Banghua Zhu , Hiteshi Sharma , Felipe Vieira Frujeri , Shi Dong , Chenguang Zhu , Michael I. Jordan , Jiantao Jiao

Large language models (LLMs) are designed to perform a wide range of tasks. To improve their ability to solve complex problems requiring multi-step reasoning, recent research leverages process reward modeling to provide fine-grained…

Computation and Language · Computer Science 2025-09-29 Weixuan Wang , Minghao Wu , Barry Haddow , Alexandra Birch

Language models (LMs) trained on vast quantities of text data can acquire sophisticated skills such as generating summaries, answering questions or generating code. However, they also manifest behaviors that violate human preferences, e.g.,…

Machine Learning · Computer Science 2024-04-19 Tomasz Korbak

Large language models (LLMs) have shown impressive capabilities in natural language processing tasks, including dialogue generation. This research aims to conduct a novel comparative analysis of two prominent techniques, fine-tuning with…

Prompt engineering is crucial for harnessing the potential of large language models (LLMs), especially in the medical domain where specialized terminology and phrasing is used. However, the efficacy of prompt engineering in the medical…

Computation and Language · Computer Science 2025-07-22 Jamil Zaghir , Marco Naguib , Mina Bjelogrlic , Aurélie Névéol , Xavier Tannier , Christian Lovis

Automatic prompt optimization frameworks are developed to obtain suitable prompts for large language models (LLMs) with respect to desired output quality metrics. Although existing approaches can handle conventional tasks such as…

Computation and Language · Computer Science 2025-05-14 Chun-Pai Yang , Kan Zheng , Shou-De Lin

Large language models (LLMs) exhibit remarkable performance across various NLP tasks. However, they often generate incorrect or hallucinated information, which hinders their practical applicability in real-world scenarios. Human feedback…

Computation and Language · Computer Science 2023-05-24 Wenhao Yu , Zhihan Zhang , Zhenwen Liang , Meng Jiang , Ashish Sabharwal

Large Language Models (LLMs), such as GPT3.5, have exhibited remarkable proficiency in comprehending and generating natural language. On the other hand, medical assistants hold the potential to offer substantial benefits for individuals.…

Computation and Language · Computer Science 2024-04-05 Kai Zhang , Yangyang Kang , Fubang Zhao , Xiaozhong Liu

Personalized preference alignment for large language models (LLMs), the process of tailoring LLMs to individual users' preferences, is an emerging research direction spanning the area of NLP and personalization. In this survey, we present…

Recently, preference optimization methods such as DPO have significantly enhanced large language models (LLMs) in wide tasks including dialogue and question-answering. However, current methods fail to account for the varying difficulty…

Computation and Language · Computer Science 2024-12-31 Jingyuan Ma , Rui Li , Zheng Li , Lei Sha , Zhifang Sui

Large Language Models (LLMs) are known to overuse certain terms like "delve" and "intricate." The exact reasons for these lexical choices, however, have been unclear. Using Meta's Llama model, this study investigates the contribution of…

Computation and Language · Computer Science 2025-08-05 Tom S. Juzek , Zina B. Ward

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

Computation and Language · Computer Science 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Aligning large language models (LLMs) with human preferences has proven to drastically improve usability and has driven rapid adoption as demonstrated by ChatGPT. Alignment techniques such as supervised fine-tuning (SFT) and reinforcement…

The recommendation of medication is a vital aspect of intelligent healthcare systems, as it involves prescribing the most suitable drugs based on a patient's specific health needs. Unfortunately, many sophisticated models currently in use…

Information Retrieval · Computer Science 2025-01-28 Qidong Liu , Xian Wu , Xiangyu Zhao , Yuanshao Zhu , Zijian Zhang , Feng Tian , Yefeng Zheng

This paper studies reinforcement learning from human feedback (RLHF) for aligning large language models with human preferences. While RLHF has demonstrated promising results, many algorithms are highly sensitive to misspecifications in the…

Machine Learning · Computer Science 2025-10-30 Erhan Xu , Kai Ye , Hongyi Zhou , Luhan Zhu , Francesco Quinzan , Chengchun Shi

Reinforcement learning from human feedback (RLHF) has emerged as the primary method for aligning large language models (LLMs) with human preferences. While it enables LLMs to achieve human-level alignment, it often incurs significant…

Computation and Language · Computer Science 2025-03-21 Shivank Garg , Ayush Singh , Shweta Singh , Paras Chopra

Recent preference learning frameworks for large language models (LLMs) simplify human preferences with binary pairwise comparisons and scalar rewards. This simplification could make LLMs' responses biased to mostly preferred features, and…

Machine Learning · Computer Science 2025-06-16 Dongyoung Kim , Jinsung Yoon , Jinwoo Shin , Jaehyung Kim

For aligning large language models (LLMs), prior work has leveraged reinforcement learning via human feedback (RLHF) or variations of direct preference optimization (DPO). While DPO offers a simpler framework based on maximum likelihood…

Artificial Intelligence · Computer Science 2025-05-27 Anirudhan Badrinath , Prabhat Agarwal , Jiajing Xu
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