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We present a method for enhanced sampling of molecular dynamics simulations using stochastic resetting. Various phenomena, ranging from crystal nucleation to protein folding, occur on timescales that are unreachable in standard simulations.…

Chemical Physics · Physics 2023-02-09 Ofir Blumer , Shlomi Reuveni , Barak Hirshberg

Robust motion planning entails computing a global motion plan that is safe under all possible uncertainty realizations, be it in the system dynamics, the robot's initial position, or with respect to external disturbances. Current approaches…

Robotics · Computer Science 2022-11-02 Albert Wu , Thomas Lew , Kiril Solovey , Edward Schmerling , Marco Pavone

In this paper, we present an overview of different types of random walk strategies with local and non-local transitions on undirected connected networks. We present a general approach to analyzing these strategies by defining the dynamics…

Statistical Mechanics · Physics 2020-07-08 A. P. Riascos , José L. Mateos

This two-part paper discusses robustification methodologies for linear-iterative distributed algorithms for consensus and coordination problems in multicomponent systems, in which unreliable communication links may drop packets. We consider…

Systems and Control · Computer Science 2011-09-30 Alejandro D. Dominguez-Garcia , Christoforos N. Hadjicostis , Nitin H. Vaidya

Reinforcement learning (RL) has made significant advancements, achieving superhuman performance in various tasks. However, RL agents often operate under the assumption of environmental stationarity, which poses a great challenge to learning…

Machine Learning · Computer Science 2025-11-18 Guoqing Ma , Yuhan Zhang , Yuming Dai , Guangfu Hao , Yang Chen , Shan Yu

Many state of the art methods for the thermodynamic and kinetic characterization of large and complex biomolecular systems by simulation rely on ensemble approaches, where data from large numbers of relatively short trajectories are…

Data Analysis, Statistics and Probability · Physics 2017-04-05 Feliks Nüske , Hao Wu , Jan-Hendrik Prinz , Christoph Wehmeyer , Cecilia Clementi , Frank Noé

We propose a greedy reconstruction algorithm to find the probability distribution of a parameter characterizing an inhomogeneous spin ensemble in Nuclear Magnetic Resonace. The identification is based on the application of a number of…

Quantum Physics · Physics 2021-12-22 S. Buchwald , G. Ciaramella , J. Salomon , D. Sugny

We consider the problem of learning linear prediction models with model misspecification bias. In such case, the collinearity among input variables may inflate the error of parameter estimation, resulting in instability of prediction…

Machine Learning · Computer Science 2019-12-02 Zheyan Shen , Peng Cui , Tong Zhang , Kun Kuang

Many chemical reactions can be formulated in terms of particle diffusion in a complex energy landscape. Transition path theory (TPT) is a theoretical framework for describing the direct (reaction) pathways from reactant to product states…

Statistical Mechanics · Physics 2023-10-03 Paul C Bressloff

Motivated by practical applications where stable long-term performance is critical-such as robotics, operations research, and healthcare-we study the problem of distributionally robust (DR) average-reward reinforcement learning. We propose…

Machine Learning · Computer Science 2026-02-03 Zijun Chen , Shengbo Wang , Nian Si

The dynamics of molecules are governed by rare event transitions between long-lived (metastable) states. To explore these transitions efficiently, many enhanced sampling protocols have been introduced that involve using simulations with…

Chemical Physics · Physics 2022-09-30 Maaike M. Galama , Hao Wu , Andreas Krämer , Mohsen Sadeghi , Frank Noé

We consider the problem of approximating the stationary distribution of an ergodic Markov chain given a set of sampled transitions. Classical simulation-based approaches assume access to the underlying process so that trajectories of…

Machine Learning · Computer Science 2020-03-03 Junfeng Wen , Bo Dai , Lihong Li , Dale Schuurmans

Background: Phase I dose-finding trials increasingly encounter delayed-onset toxicities, especially with immunotherapies and targeted agents. The time-to-event continual reassessment method (TITE-CRM) handles incomplete follow-up using…

Methodology · Statistics 2026-02-24 Robert Amevor , Emmanuel Kubuafor , Dennis Baidoo

Physically motivated stochastic dynamics are often used to sample from high-dimensional distributions. However such dynamics often get stuck in specific regions of their state space and mix very slowly to the desired stationary state. This…

Machine Learning · Statistics 2025-05-13 Abhijith Jayakumar , Andrey Y. Lokhov , Sidhant Misra , Marc Vuffray

In this paper, we address the efficient implementation of moving horizon state estimation of constrained discrete-time linear systems. We propose a novel iteration scheme which employs a proximity-based formulation of the underlying…

Optimization and Control · Mathematics 2021-11-09 Meriem Gharbi , Bahman Gharesifard , Christian Ebenbauer

This paper proposes a metric for sets of trajectories to evaluate multi-object tracking algorithms that includes time-weighted costs for localisation errors of properly detected targets, for false targets, missed targets and track switches.…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Ángel F. García-Fernández , Abu Sajana Rahmathullah , Lennart Svensson

This paper introduces a new algorithm for numerically computing equilibrium (i.e. stationary) distributions for Markov chains and Markov jump processes with either a very large finite state space or a countably infinite state space. The…

Probability · Mathematics 2022-08-31 Alex Infanger , Peter W. Glynn

Probabilistic model checking traditionally verifies properties on the expected value of a measure of interest. This restriction may fail to capture the quality of service of a significant proportion of a system's runs, especially when the…

Artificial Intelligence · Computer Science 2025-02-10 Xiaotong Ji , Hanchun Wang , Antonio Filieri , Ilenia Epifani

Enhancing the stability of machine learning algorithms under distributional shifts is at the heart of the Out-of-Distribution (OOD) Generalization problem. Derived from causal learning, recent works of invariant learning pursue strict…

Machine Learning · Computer Science 2024-02-15 Jiashuo Liu , Jiayun Wu , Jie Peng , Xiaoyu Wu , Yang Zheng , Bo Li , Peng Cui

This paper considers the problem of minimizing the sum of a smooth function and the Schatten-$p$ norm of the matrix. Our contribution involves proposing accelerated iteratively reweighted nuclear norm methods designed for solving the…

Optimization and Control · Mathematics 2024-06-27 Hao Wang , Ye Wang , Xiangyu Yang
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