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Microscopy is a primary source of information on materials structure and functionality at nanometer and atomic scales. The data generated is often well-structured, enriched with metadata and sample histories, though not always consistent in…

We consider the numerical optimization of performance for a computational extension of a confocal microscope. Using a system where the pinhole detector is replaced with a detector array, we seek to exploit this additional information for…

Signal Processing · Electrical Eng. & Systems 2020-12-15 Keith Dillon

Although learning from data is effective and has achieved significant milestones, it has many challenges and limitations. Learning from data starts from observations and then proceeds to broader generalizations. This framework is…

Machine Learning · Computer Science 2021-07-29 Ahmad Hammoudeh , Sara Tedmori , Nadim Obeid

Hyperspectral sensors enable the study of the chemical properties of scene materials remotely for the purpose of identification, detection, and chemical composition analysis of objects in the environment. Hence, hyperspectral images…

Computer Vision and Pattern Recognition · Computer Science 2019-02-12 Utsav B. Gewali , Sildomar T. Monteiro , Eli Saber

To have the greatest impact, public health initiatives must be made using evidence-based decision-making. Machine learning Algorithms are created to gather, store, process, and analyse data to provide knowledge and guide decisions. A…

Machine Learning · Computer Science 2022-09-28 Imen Jdey , Ghazala Hcini , Hela Ltifi

Scanning microscopy systems, such as confocal and multiphoton microscopy, are powerful imaging tools for probing deep into biological tissue. However, scanning systems have an inherent trade-off between acquisition time, field of view,…

Image and Video Processing · Electrical Eng. & Systems 2025-03-25 Cassandra Tong Ye , Jiashu Han , Kunzan Liu , Anastasios Angelopoulos , Linda Griffith , Kristina Monakhova , Sixian You

Recently, deep learning approaches have become the main research frontier for biological image reconstruction and enhancement problems thanks to their high performance, along with their ultra-fast inference times. However, due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Mehmet Akçakaya , Burhaneddin Yaman , Hyungjin Chung , Jong Chul Ye

The mammalian brain is a densely interconnected network that consists of millions to billions of neurons. Decoding how information is represented and processed by this neural circuitry requires the ability to capture and manipulate the…

Biological Physics · Physics 2018-05-10 Siegfried Weisenburger , Alipasha Vaziri

Biomedical photoacoustic tomography, which can provide high resolution 3D soft tissue images based on the optical absorption, has advanced to the stage at which translation from the laboratory to clinical settings is becoming possible. The…

Image and Video Processing · Electrical Eng. & Systems 2020-11-20 Andreas Hauptmann , Ben Cox

Light-field imaging is an emerging paradigm in biomedical optics, offering the unique ability to capture volumetric information in a single snapshot by encoding both the spatial and angular components of light. Unlike conventional…

Optics · Physics 2025-09-30 Ruixuan Zhao , Xuanwen Hua , Woongjae Baek , Zhaoqiang Wang , Shu Jia , Liang Gao

The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice. For instance, the…

Machine Learning · Computer Science 2023-01-30 Can Cui , Haichun Yang , Yaohong Wang , Shilin Zhao , Zuhayr Asad , Lori A. Coburn , Keith T. Wilson , Bennett A. Landman , Yuankai Huo

Data-driven science is heralded as a new paradigm in materials science. In this field, data is the new resource, and knowledge is extracted from materials data sets that are too big or complex for traditional human reasoning - typically…

Computational Physics · Physics 2019-10-28 Lauri Himanen , Amber Geurts , Adam S. Foster , Patrick Rinke

Stochastic optimisation algorithms are the de facto standard for machine learning with large amounts of data. Handling only a subset of available data in each optimisation step dramatically reduces the per-iteration computational costs,…

Numerical Analysis · Mathematics 2024-12-19 Matthias J. Ehrhardt , Zeljko Kereta , Jingwei Liang , Junqi Tang

We demonstrate that embedding physics-driven constraints into machine learning process can dramatically improve accuracy and generalizability of the resulting model. Physics-informed learning is illustrated on the example of analysis of…

Computational Physics · Physics 2021-12-16 Abantika Ghosh , Mohannad Elhamod , Jie Bu , Wei-Cheng Lee , Anuj Karpatne , Viktor A Podolskiy

Most machine learning models require many iterations of hyper-parameter tuning, feature engineering, and debugging to produce effective results. As machine learning models become more complicated, this pipeline becomes more difficult to…

Machine Learning · Computer Science 2024-08-26 Mirabel Reid , Christine Sweeney , Oleg Korobkin

In this big data era, the use of large dataset in conjunction with machine learning (ML) has been increasingly popular in both industry and academia. In recent times, the field of materials science is also undergoing a big data revolution,…

Materials Science · Physics 2023-09-27 Sue Sin Chong , Yi Sheng Ng , Hui-Qiong Wang , Jin-Cheng Zheng

As microscopy diversifies and becomes ever-more complex, the problem of quantification of microscopy images has emerged as a major roadblock for many researchers. All researchers must face certain challenges in turning microscopy images…

Other Quantitative Biology · Quantitative Biology 2024-03-28 Beth A Cimini

In recent years, deep learning has achieved remarkable empirical success for image reconstruction. This has catalyzed an ongoing quest for precise characterization of correctness and reliability of data-driven methods in critical use-cases,…

Computer Vision and Pattern Recognition · Computer Science 2022-09-15 Subhadip Mukherjee , Andreas Hauptmann , Ozan Öktem , Marcelo Pereyra , Carola-Bibiane Schönlieb

We consider the optimization of an uncertain objective over continuous and multi-dimensional decision spaces in problems in which we are only provided with observational data. We propose a novel algorithmic framework that is tractable,…

Machine Learning · Statistics 2018-10-30 Dimitris Bertsimas , Christopher McCord

Coherent microscopy techniques provide an unparalleled multi-scale view of materials across scientific and technological fields, from structural materials to quantum devices, from integrated circuits to biological cells. Driven by the…