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In topological data analysis, we want to discern topological and geometric structure of data, and to understand whether or not certain features of data are significant as opposed to simply random noise. While progress has been made on…

Computational Geometry · Computer Science 2020-01-10 So Mang Han , Taylor Okonek , Nikesh Yadav , Xiaojun Zheng

Topological data analysis (TDA), as a relatively recent approach, has demonstrated great potential in capturing the intrinsic and robust structural features of complex data. While persistent homology, as a core tool of TDA, focuses on…

Combinatorics · Mathematics 2025-11-11 Jing-Wen Gao , Yunan He , Jian Liu

We develop a framework for comparing data manifolds, aimed, in particular, towards the evaluation of deep generative models. We describe a novel tool, Cross-Barcode(P,Q), that, given a pair of distributions in a high-dimensional space,…

Topology applied to real world data using persistent homology has started to find applications within machine learning, including deep learning. We present a differentiable topology layer that computes persistent homology based on level set…

Topological data analysis (TDA) uncovers crucial properties of objects in medical imaging. Methods based on persistent homology have demonstrated their advantages in capturing topological features that traditional deep learning methods…

Computer Vision and Pattern Recognition · Computer Science 2024-08-16 Yanfan Zhu , Yash Singh , Khaled Younis , Shunxing Bao , Yuankai Huo

In a world abundant with diverse data arising from complex acquisition techniques, there is a growing need for new data analysis methods. In this paper we focus on high-dimensional data that are organized into several hierarchical datasets.…

Machine Learning · Computer Science 2021-04-06 Lior Aloni , Omer Bobrowski , Ronen Talmon

Topological data analysis is a relatively new branch of machine learning that excels in studying high dimensional data, and is theoretically known to be robust against noise. Meanwhile, data objects with mixed numeric and categorical…

Algebraic Topology · Mathematics 2020-06-15 Chengyuan Wu , Carol Anne Hargreaves

Persistent Homology (PH) has been successfully used to train networks to detect curvilinear structures and to improve the topological quality of their results. However, existing methods are very global and ignore the location of topological…

Computer Vision and Pattern Recognition · Computer Science 2022-12-27 Doruk Oner , Adélie Garin , Mateusz Koziński , Kathryn Hess , Pascal Fua

Persistent homology has been devised as a promising tool for the topological simplification of complex data. However, it is computationally intractable for large data sets. In this work, we introduce multiresolution persistent homology for…

Biomolecules · Quantitative Biology 2015-04-02 Kelin Xia , Zhixiong Zhao , Guo-Wei Wei

Topological data analysis (TDA) is a branch of computational mathematics, bridging algebraic topology and data science, that provides compact, noise-robust representations of complex structures. Deep neural networks (DNNs) learn millions of…

Topological data analysis (TDA) detects geometric structure in biological data. However, many TDA algorithms are memory intensive and impractical for massive datasets. Here, we introduce a statistical protocol that reduces TDA's memory…

Quantitative Methods · Quantitative Biology 2025-09-05 Andrew J. Stier , Naichen Shi , Raed Al Kontar , Chad Giusti , Marc G. Berman

The theory of multidimensional persistence captures the topology of a multifiltration -- a multiparameter family of increasing spaces. Multifiltrations arise naturally in the topological analysis of scientific data. In this paper, we give a…

Computational Geometry · Computer Science 2010-11-22 Gunnar Carlsson , Gurjeet Singh , Afra Zomorodian

Characterizing the dynamics of time-evolving data within the framework of topological data analysis (TDA) has been attracting increasingly more attention. Popular instances of time-evolving data include flocking/swarming behaviors in…

Algebraic Topology · Mathematics 2021-08-04 Woojin Kim , Facundo Memoli

Given an unknown $\mathbb{R}^n$-valued function $f$ on a metric space $X$, can we approximate the persistent homology of $f$ from a finite sampling of $X$ with known pairwise distances and function values? This question has been answered in…

Algebraic Topology · Mathematics 2026-03-20 Ethan André , Jingyi Li , David Loiseaux , Steve Oudot

In this study, we present a novel molecular fingerprint generation method based on multiparameter persistent homology. This approach reveals the latent structures and relationships within molecular geometry, and detects topological features…

Biomolecules · Quantitative Biology 2023-11-21 Andac Demir , Bulent Kiziltan

Persistent homology has emerged as a popular technique for the topological simplification of big data, including biomolecular data. Multidimensional persistence bears considerable promise to bridge the gap between geometry and topology.…

Biomolecules · Quantitative Biology 2014-12-25 Kelin Xia , Guo-Wei Wei

Understanding the behavior and evolution of a dynamical many-body system by analyzing patterns in their experimentally captured images is a promising method relevant for a variety of living and non-living self-assembled systems. The arrays…

Topological data analysis (TDA) is a relatively new field that is gaining rapid adoption due to its robustness and ability to effectively describe complex datasets by quantifying geometric information. In imaging contexts, TDA typically…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Aaryam Sharma

Deep generative models have emerged as a powerful tool for learning useful molecular representations and designing novel molecules with desired properties, with applications in drug discovery and material design. However, most existing deep…

Scientific data has been growing in both size and complexity across the modern physical, engineering, life and social sciences. Spatial structure, for example, is a hallmark of many of the most important real-world complex systems, but its…